Review
Medicine, General & Internal
A. D. Smith, H. Refsum
Summary: Elevated concentrations of plasma total homocysteine are associated with over 100 diseases or conditions, with cardiovascular diseases and diseases of the central nervous system being the most common. Lowering total homocysteine through B vitamin treatment may prevent certain diseases, indicating the clinical importance of these associations.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Lidan Zheng, Fiona E. Matthews, Kaarin J. Anstey
Summary: This study found that cardiovascular diseases are associated with a decrease in lifespan and cognitive impairment-free life expectancy, with stroke patients having the shortest lifespan and cognitive impairment-free life expectancy. Analysis of multiple cardiovascular risk factors revealed that each additional cardiovascular condition was exponentially linked to a decrease in lifespan and cognitive impairment-free life expectancy.
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Geriatrics & Gerontology
Mengshu Yang, Yilan Liu, Xiuzhen Hu, Dianxu Ren, Qing Yang, Jing Mao, Jing Chen
Summary: Life's Simple 7 (LS7), initiated by the American Heart Association, includes seven intervenable cardiovascular risk factors to improve cardiovascular health. This study investigated the association between LS7 metrics and mild cognitive impairment (MCI) in community-dwelling older adults. The results showed that LS7 was associated with MCI, suggesting its potential use in the prevention of dementia in the community.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Environmental Sciences
Yijia Zhang, Liping Lu, Cheng Chen, Ka Kahe, R. William Field, Mary D' Alton
Summary: Radon, a radioactive gas, is potentially associated with the development of dementia. Evidence suggests that disproportionately high deposition of radon decay products (RDPs) occurs in the brains of AD patients, with selective accumulation within protein fractions. Geographical distribution of radon also shows a significant positive correlation with AD mortality in the US.
ENVIRONMENTAL RESEARCH
(2022)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychiatry
Azizi Seixas, Farid A. Rajabli, Margaret Pericak-Vance, Girardin L. Jean-Louis, Ioannis Tarnanas
Summary: This study investigated a digital neuro signature biomarker in predicting cognitive functioning and changes in older adults, compared to traditional biomarkers. The study also explored which demographic and clinical factors predicted the digital neuro signature biomarker in cognitively impaired and healthy older adults. The findings suggest that digital biomarkers may offer more reliable predictions of cognitive functioning and changes in older adults compared to traditional biomarkers.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Hugo Juan Camilo Clavijo-Moran, Daniela Alvarez-Garcia, Gabriel D. Pinilla-Monsalve, Beatriz Munoz-Ospina, Jorge Orozco
Summary: This study investigated the cognitive assessment scale for patients with Parkinson's disease in the Colombian population and found that the Parkinson's Disease Cognitive Rating Scale (PD-CRS) has acceptable psychometric properties and significant correlation and agreement with another validated scale (MoCA).
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neurosciences
Seung Wan Suh, You Joung Kim, Kyung Phil Kwak, Kiwon Kim, Moon-Doo Kim, Byung-Soo Kim, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Tae Hui Kim, Seok Woo Moon, Kyung Won Park, Jong-Il Park, Joon Hyuk Park, Jae Nam Bae, Jiyeong Seo, Su Jeong Seong, Sang Joon Son, Il-Seon Shin, Seung-Ho Ryu, Kang Joon Lee, Nam-Jin Lee, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Chang Uk Lee, Sung Man Chang, Hyun-Ghang Jeong, Maeng Je Cho, Seong-Jin Cho, Jin Hyeong Jhoo, Young Min Choe, Ji Won Han, Ki Woong Kim
Summary: The prevalence of dementia in elderly populations in Korea showed a nonsignificant decrease between 2008 and 2017, with Alzheimer's disease also decreasing slightly while mild cognitive impairment remained stable.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Dana Pourzinal, Jihyun Yang, Rachael A. Lawson, Katie L. McMahon, Gerard J. Byrne, Nadeeka N. Dissanayaka
Summary: This review evaluates the literature on data-driven subtypes of cognition in Parkinson's disease (PD), finding that there are subtype structures either showing a spectrum of severity or specific domains of impairment. Neuroimaging evidence provides insight into distinct patterns of brain alterations among subtypes. The clinical relevance of certain cognitive subtypes in PD is highlighted, but further research is needed to explore the underlying neural mechanisms.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Vijay K. Ramanan, Melissa J. Armstrong, Parichita Choudhury, Katherine A. Coerver, Roy H. Hamilton, Brad C. Klein, David A. Wolk, Scott R. Wessels, Lyell K. Jones Jr
Summary: This article provides practical guidance on logistic adaptations and decision making related to emerging antiamyloid mAbs in neurology, including patient selection, treatment monitoring, and communication. It emphasizes the importance of shared decision making, multidisciplinary collaboration, and future development.
Review
Biochemistry & Molecular Biology
Hanan Ehtewish, Abdelilah Arredouani, Omar El-Agnaf
Summary: The underlying mechanisms linking type 2 diabetes to cognitive dysfunction are still unclear, but may include factors such as hyperglycemia, insulin resistance, and neuroinflammation. Risk factors for dementia in diabetes patients include aging, poor glycemic control, hypoglycemic and hyperglycemic episodes, depression, and vascular complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Letter
Virology
Pasquale Campana, Veronica Flocco, Francesco Aruta, Francesco Cacciatore, Pasquale Abete
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Cell Biology
David Della-Morte, Francesca Pacifici, Camillo Ricordi, Renato Massoud, Valentina Rovella, Stefania Proietti, Mariannina Iozzo, Davide Lauro, Sergio Bernardini, Stefano Bonassi, Nicola Di Daniele
Summary: This study found a significant association between low plasminogen levels and inflammatory markers, coagulation markers, and organ dysfunction markers in COVID-19 patients. Plasminogen may play a vital role in controlling the complex mechanisms behind the complications of COVID-19, serving as both a biomarker for prognosis and a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Review
Nutrition & Dietetics
Francesca Pacifici, Valentina Rovella, Donatella Pastore, Alfonso Bellia, Pasquale Abete, Giulia Donadel, Silvia Santini, Heinz Beck, Camillo Ricordi, Nicola Di Daniele, Davide Lauro, David Della-Morte
Summary: This article reviewed the association between polyphenols and stroke protection, including prevention, acute phase effects, and rehabilitation. These compounds have clinical relevance in reducing vascular risk factors for stroke.
Article
Medicine, General & Internal
Andrea Ungar, Alice Ceccofiglio, Chiara Mussi, Mario Bo, Giulia Rivasi, Martina Rafanelli, Anna Maria Martone, Giuseppe Bellelli, Franco Nicosia, Daniela Riccio, Virginia Boccardi, Elisabetta Tonon, Francesco Curcio, Francesco Landi, Pasquale Abete, Enrico Mossello
Summary: This study aimed to compare the one-year mortality risk associated with syncope and unexplained fall in older adults with dementia. The results showed that patients with Truly Unexplained Falls had a higher mortality risk compared with syncope and Syncopal Fall. For this new high-risk profile, a comprehensive geriatric assessment is advised to focus on fall risk factors for possible prognosis improvement.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Cacciatore, Giuseppe Bruzzese, Pasquale Abete, Giuseppe Russo, Wulf Palinski, Claudio Napoli
Summary: Maternal cholesterol during pregnancy is associated with the severity of acute myocardial infarction in adults.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cell Biology
Benedetta Maria Bonora, Maria Teresa Palano, Gianluca Testa, Gian Paolo Fadini, Elena Sangalli, Fabiana Madotto, Giuseppe Persico, Francesca Casciaro, Rosa Vono, Ornella Colpani, Francesco Scavello, Roberta Cappellari, Pasquale Abete, Patrizia Orlando, Franco Carnelli, Andrea Giovanni Berardi, Stefano De Servi, Angela Raucci, Marco Giorgio, Paolo Madeddu, Gaia Spinetti
Summary: Frailty is associated with increased risk of cardiovascular disease and death in older adults, but the mechanisms linking frailty and cardiovascular outcomes are mostly unknown. This study found that frail older people with comorbidities exhibit inflammaging characterized by increased expression of alarmin S100A8/A9 in HSPCs and high levels of inflammatory cytokines. This phenotype is associated with poor cardiovascular outcomes.
Article
Public, Environmental & Occupational Health
Gerardo Gerundo, Claudia Colla Ruvolo, Brunella Puzone, Gianluigi Califano, Roberto La Rocca, Valentina Parisi, Marco Capece, Giuseppe Celentano, Massimiliano Creta, Giuseppe Rengo, Dario Leosco, Pasquale Abete, Nicola Longo, Vincenzo Mirone, Nicola Ferrara
Summary: This study evaluated the quality of information on PPE use during the Covid-19 pandemic in YouTube videos. The study found that while YouTube may be recommended as a reliable source of information, a significant number of videos contained inaccuracies. Future improvements should be made to provide more comprehensive and accurate information in videos.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Genetics & Heredity
Giuseppe D'Alterio, Vito Alessandro Lasorsa, Ferdinando Bonfiglio, Sueva Cantalupo, Barbara Eleni Rosato, Immacolata Andolfo, Roberta Russo, Umberto Esposito, Giulia Frisso, Pasquale Abete, Gian Marco Cassese, Giuseppe Servillo, Ivan Gentile, Carmelo Piscopo, Matteo Della Monica, Giuseppe Fiorentino, Angelo Boccia, Giovanni Paolella, Veronica Ferrucci, Pasqualino de Antonellis, Roberto Siciliano, Fathem Asadzadeh, Pellegrino Cerino, Carlo Buonerba, Biancamaria Pierri, Massimo Zollo, Achille Iolascon, Mario Capasso
Summary: This study investigates the role of rare variants (QVs) of complement system genes in predisposing elderly individuals to asymptomatic COVID-19. The study found enrichments of QVs in three genes (MASP1, COLEC11, and COLEC10) belonging to the lectin pathway in the asymptomatic cohort. Serum analyses indicated decreased activity of the lectin pathway in asymptomatic individuals with QVs.
GENETICS IN MEDICINE
(2022)
Editorial Material
Geriatrics & Gerontology
Gianluigi Galizia, Pasquale Abete
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Editorial Material
Geriatrics & Gerontology
Gianluigi Galizia, Pasquale Abete
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Medicine, General & Internal
Marco Infante, Massimo Pieri, Santina Lupisella, Ali Mohamad, Sergio Bernardini, David Della-Morte, Andrea Fabbri, Alberto De Stefano, Marco Iannetta, Lorenzo Ansaldo, Angela Crea, Massimo Andreoni, Maria Morello
Summary: Type 2 diabetes mellitus and impaired kidney function are linked to a higher risk of adverse outcomes in COVID-19. This study found that admission estimated glomerular filtration rate and white blood cell count were significantly associated with in-hospital mortality among patients with diabetes and COVID-19.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Immunology
Marco Infante, Laura Vitiello, Andrea Fabbri, Camillo Ricordi, Nathalia Padilla, Francesca Pacifici, Pasquale Di Perna, Marina Passeri, David Della-Morte, Massimiliano Caprio, Luigi Uccioli
Summary: We describe a case of a 22-year-old Italian man with new-onset type 1 diabetes who experienced an unusually prolonged clinical remission phase (31 months). The patient was treated with calcifediol and low-dose insulin, resulting in the maintenance of residual beta-cell function and clinical remission. This may be attributed to the immunoregulatory properties of calcifediol.
Article
Geriatrics & Gerontology
Francesco Curcio, Alessio De Vita, Gerardo Gerundo, Brunella Puzone, Veronica Flocco, Teresa Cante, Pietro Medio, Antonio Cittadini, Ivan Gentile, Francesco Cacciatore, Gianluca Testa, Ilaria Liguori, Pasquale Abete
Summary: This study assesses the reliability of the fr-AGILE tool for evaluating multidimensional frailty in older adults hospitalized with COVID-19. The results show that frailty severity increases with age and is associated with non-invasive ventilation, chest tomography scores, and in-hospital mortality. The fr-AGILE tool demonstrates good internal consistency and inter-rater reliability.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Geriatrics & Gerontology
Francesca Remelli, Elisa Maietti, Pasquale Abete, Giuseppe Bellelli, Mario Bo, Antonio Cherubini, Francesco Corica, Mauro Di Bari, Marcello Maggio, Maria Rosaria Rizzo, Andrea P. Rossi, Francesco Landi, Stefano Volpato
Summary: This study investigated the prevalence of sarcopenic obesity in older individuals according to EWGSOP2 and FNIH criteria. Results showed different prevalence rates of obesity and diabetes based on the two definitions, with diabetic patients more likely to be sarcopenic according to FNIH criteria.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
