Review
Biochemistry & Molecular Biology
Lucia Lopez-Gil, Amparo Pascual-Ahuir, Markus Proft
Summary: This scientific review highlights the central importance of genomic instability in the aging process and explores the cellular and molecular changes associated with aging, as well as the genetic and epigenetic alterations that contribute to genomic instability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yiran Meng, Joana Carrelha, Roy Drissen, Xiying Ren, Bowen Zhang, Adriana Gambardella, Simona Valletta, Supat Thongjuea, Sten Eirik Jacobsen, Claus Nerlov
Summary: The lymphoid fate in haematopoietic stem cells is determined through epigenetic programming rather than transcriptional control, which also influences the differentiation pathways of platelets with distinct kinetics.
NATURE CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tatiana L. Fonseca, Tzintzuni Garcia, Gustavo W. Fernandes, T. Murlidharan Nair, Antonio C. Bianco
Summary: The study demonstrates that type 2 deiodinase (D2) in neonatal liver accelerates T3 production, permanently modifying hepatic gene expression. Lack of D2 leads to DNA methylation at specific sites in the liver, resulting in reduced expression of multiple genes in Alb-D2KO mice.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Allyson J. Merrell, Tao Peng, Jinyang Li, Kathryn Sun, Bin Li, Takeshi Katsuda, Markus Grompe, Kai Tan, Ben Z. Stanger
Summary: Hepatocytes undergo extensive chromatin and transcriptional changes during biliary reprogramming, resulting in altered gene expression profiles including robust induction of biliary genes and weaker repression of hepatocyte genes. Single-cell analysis revealed that Smad4 mutation can significantly increase reprogramming.
Review
Cardiac & Cardiovascular Systems
Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu
Summary: Environment, diseases, lack of exercise, and aged tendency of population have become crucial factors that induce vascular aging, which is an unmodifiable risk factor for diseases like diabetes and hypertension. Recent transformative omics approaches have enabled a better understanding of vascular aging mechanisms, making it possible to slow down or reverse the aging process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Matin Miryeganeh
Summary: Senescence is a major developmental transition in plants that involves gene reprogramming and multilevel regulation. Transcription factors and epigenetic mechanisms play crucial roles in senescence-related genes, in addition to genetic reprogramming.
Article
Biology
Saskia-Larissa Jauch-Speer, Marisol Herrera-Rivero, Nadine Ludwig, Bruna Caroline Veras De Carvalho, Leonie Martens, Jonas Wolf, Achmet Imam Chasan, Anika Witten, Birgit Markus, Bernhard Schieffer, Thomas Vogl, Jan Rossaint, Monika Stoll, Johannes Roth, Olesja Fehler
Summary: This study identified C/EBP delta as a new regulator of S100a8 and S100a9 expression and demonstrated its regulatory effects on inflammation. The study also revealed the regulatory mechanisms of C/EBP delta on S100a8 and S100a9 expression and its association with subpopulations of human monocytes in cardiovascular patients.
Article
Biotechnology & Applied Microbiology
Zhengmao Song, Yun Wang, Pingli Lin, Kaichun Yang, Xilin Jiang, Junchen Dong, Shangjin Xie, Rong Rao, Lishan Cui, Feng Liu, Xuefeng Huang
Summary: This study identified two gene modules and 16 driving genes associated with the progression of nonalcoholic fatty liver disease (NAFLD) using weighted gene co-expression network analysis. One of the most notable driving genes was CCAAT/enhancer binding protein alpha (C/EBP alpha). The protein expression of C/EBP alpha was found to be significantly upregulated in NAFLD. These findings advance the understanding of NAFLD and provide potential biomarkers and therapeutic targets.
Article
Biochemistry & Molecular Biology
Lin Yan, Shuo Gao, Jun Zhu, Jun Zhou
Summary: This study reveals the role of irf2bp2a in inducing apoptosis of hepatic cells through aberrant p53 activation during the early stage of embryonic development. Mechanistic studies show that the lack of IRF2BP2 in hepatic cells sequesters more MDM2 molecules into the IRF2-MDM2 complex, leading to the stabilization of P53 protein. In addition, irf2bp2a is identified as a direct downstream target of c/ebp alpha.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Food Science & Technology
Alexandre Ferro Aissa, Volodymyr P. Tryndyak, Aline de Conti, Ana Rita Thomazela Machado, Katiuska Tuttis, Carla da Silva Machado, Livia Cristina Hernandes, Patrick Wellington da Silva Santos, Juliana Mara Serpeloni, Igor P. Pogribny, Lusania Maria Greggi Antunes
Summary: A diet deficient in donors of methyl group, such as methionine, affects DNA methylation, hepatic lipid metabolism, and other epigenetic mechanisms. This study investigated the effects of methionine-supplemented or methionine-deficient diets on chromatin-modifying genes, global DNA methylation, genes related to lipid metabolism, and microRNAs in mouse liver. Both diets altered gene expression, global DNA methylation, and microRNA expression, with the methionine-deficient diet having a more substantial effect.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Yi Zhang, Jinbi Zhang, Caixia Wang, Hongjian Dai, Xing Du, Qifa Li, Zengxiang Pan
Summary: In this study, three markers including H3K27ac, H3K4me1, and C-EBP beta were used to compare the characteristics of promoters, enhancers, and super-enhancers in the porcine liver. The results provided novel insights into the locational, sequential, and functional differences of cis-elements and their connection to transcriptional initiation of genes.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Cell Biology
Simon Yuan Wang, Kathleen Kim, Zach Klapholz O'Brown, Aileen Levan, Anne Elizabeth Dodson, Scott G. Kennedy, Chaim Chernoff, Eric Lieberman Greer
Summary: Research reveals that exposure to hypoxia in ancestors can lead to reduced lipids and fertility in the descendants reared in normoxia. The transmission of these phenotypic consequences is dependent on histone-modifying enzymes and argonaute HRDE-1. Additionally, small RNAs can be transmitted from parents to their naïve children, resulting in fertility defects.
Article
Biotechnology & Applied Microbiology
Anjana Ramdas Nair, Priyanka Lakhiani, Chi Zhang, Filippo Macchi, Kirsten C. Sadler
Summary: Restoration of homeostasis following proteostatic stress relies on stress-specific transcriptional signatures. Using functional genomics, we identified conserved putative ATF6 targets that function in various biological processes. ATF6 activation led to distinct CPAT signatures under different stress conditions, suggesting a permissive epigenetic landscape for stress-specific gene expression.
Article
Food Science & Technology
Xiaohong Lin, Weiye Xu, Liu Liu, Shiyi Ou, Xichun Peng
Summary: The metabolites of flaxseed polysaccharide fermented by fecal bacteria were found to inhibit glucose intake and lipid accumulation, which might be a weight-loss mechanism of flaxseed polysaccharide through regulating intestinal microbiota.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Evan W. Weber, Kevin R. Parker, Elena Sotillo, Rachel C. Lynn, Hima Anbunathan, John Lattin, Zinaida Good, Julia A. Belk, Bence Daniel, Dorota Klysz, Meena Malipatlolla, Peng Xu, Malek Bashti, Sabine Heitzeneder, Louai Labanieh, Panayiotis Vandris, Robbie G. Majzner, Yanyan Qi, Katalin Sandor, Ling-Chun Chen, Snehit Prabhu, Andrew J. Gentles, Thomas J. Wandless, Ansuman T. Satpathy, Howard Y. Chang, Crystal L. Mackall
Summary: This study showed that transient cessation of chimeric antigen receptor (CAR) signaling can enhance the efficacy of CAR-T cells, reactivating their anti-tumor functions, and challenging the notion that exhaustion is an epigenetically fixed state.