期刊
AGEING RESEARCH REVIEWS
卷 11, 期 4, 页码 423-431出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2012.01.005
关键词
RNA-binding protein; Post-transcriptional gene regulation; Aging; Cellular senescence; Human diploid fibroblasts; Human tissue array
资金
- Grants-in-Aid for Scientific Research [22390146, 22790649, 21119003, 24790705, 24590943] Funding Source: KAKEN
Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner. RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically affect the subsets of expressed proteins. Although many proteins implicated in age-related processes are encoded by mRNAs that are targets of TTR-RBPs, very little is known regarding the tissue- and age-dependent expression of TTR-RBPs in humans. Recent analysis of TTR-RBPs expression using human tissue microarray has provided us interesting insight into their possibly physiologic roles as a function of age. This analysis has also revealed striking discrepancies between the levels of TTR-RBPs in senescent human diploid fibroblasts (HDFs), widely used as an in vitro model of aging, and the levels of TTR-RBPs in tissues from individuals of advancing age. In this article, we will review our knowledge of human TTR-RBP expression in different tissues as a function of age. (C) 2012 Elsevier B.V. All rights reserved.
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