期刊
AGEING RESEARCH REVIEWS
卷 10, 期 1, 页码 173-177出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2010.10.006
关键词
Very small embryonic-like stem cells (VSELs); Acute myocardial infarction (AMI); Cardiac repair; Mobilization; Transplantation
资金
- National High Technology Research and Development Program (863 Program) [2007AA02Z4Z5]
- China Health & Medical Development Foundation [2008-zhfj2]
- Research Fund of Capital Medical Development
- National Natural Science Foundation of China [81070169, 81000091]
- Beijing Novel Program [2008B78]
- Chinese Medical Association [07060690077]
In recent years, stem cell-based therapy has been given increased attention in terms of its potential contribution to cardiac regeneration and repair, after acute myocardial infarction (AMI). The published studies have identified many kinds of stem cells with the ability to regenerate and repair damaged myocardium after AMI. These include embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), multipotent adult progenitor cells, unrestricted somatic stem cells, etc. More recently, very small embryonic-like stem cells (VSELs) were identified from murine, as a population of very small CXCR4(+) Lin(-) CD45(-) cells and from human, as a population of very small CD34(+) CD133(+) CXCR4(+) Lin(-) CD45(-) cells. These cells exhibit beneficial effects on improving cardiac function and attenuating cardiac remodeling after AMI. However, the mechanisms underlying the benefits associated with VSELs therapy, in cardiac regeneration and repair, remain poorly understood. This review summarizes the current studies on cardiac repair with VSELs after AMI, and discusses the potential mechanisms and implications of these cells in cardiac repair. (C) 2010 Elsevier B.V. All rights reserved.
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