Review
Neurosciences
Weihao Wang, Xiaoye Duan, Zhengxiang Huang, Qi Pan, Chen Chen, Lixin Guo
Summary: Organisms have developed common behavioral and physiological adaptations to the day/night cycle, with the CLOCK system forming an internal circadian rhythm that may influence growth hormone secretion, the GH-insulin-like growth factor 1 axis, and metabolism.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Claudia Campana, Francesco Cocchiara, Giuliana Corica, Federica Nista, Marica Arvigo, Jessica Amaru, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Federico Gatto
Summary: Discordance between GH and IGF-1 levels in acromegaly patients is influenced by GH cutoff values. The use of GH(m) can mitigate the impact of GH cutoffs and improve predictive accuracy. Fasting GH levels (both GH(f) and GH(m)) are poor predictors of IGF-1 normalization in this cohort.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Sabrina Angelini, Maria E. Street
Summary: Growth hormone and the insulin-like growth factor system play crucial roles in cell proliferation, differentiation, apoptosis, and angiogenesis, while miRNAs and lncRNAs regulate gene expression and have been linked to diseases such as cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
William B. Zhang, Kenny Ye, Nir Barzilai, Sofiya Milman
Summary: The study found two generalized patterns in the relationship between serum IGF-1 levels and clinical disease: IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy, and the association between IGF-1 and risk is generally U-shaped. These effects were remarkably consistent across a wide range of conditions, except for a more uniformly positive relationship between IGF-1 and cancer.
Article
Endocrinology & Metabolism
Vivian Hwa, Masanobu Fujimoto, Gaohui Zhu, Wen Gao, Corinne Foley, Meenasri Kumbaji, Ron G. Rosenfeld
Summary: Growth hormone insensitivity (GHI) syndrome is linked to monogenic defects in the growth hormone receptor (GHR) gene, causing growth failure. Recognition of other monogenic defects downstream of GHR has greatly expanded understanding of the primary causes of GHI and growth retardation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Review
Cell Biology
Marina Caputo, Stella Pigni, Emanuela Agosti, Tommaso Daffara, Alice Ferrero, Nicoletta Filigheddu, Flavia Prodam
Summary: Growth hormone (GH) and insulin-like growth factor-1 (IGF-I) play crucial roles in lifespan, growth, metabolism, and nutrient utilization. Nutrients are essential modifiers of the GH/IGF-I axis, and these hormones also regulate the utilization of nutrients in cells and tissues.
Article
Endocrinology & Metabolism
Omar Al-Massadi, Paolo Parini, Johan Ferno, Serge Luquet, Mar Quinones
Summary: The growth hormone/insulin growth factor-1 axis plays a crucial role in regulating metabolism through its actions on peripheral tissues and the brain. It is involved in controlling food intake, energy expenditure, and glycemia, and interacts with the central nervous system. Dysregulation of this hepatic axis can lead to metabolic disorders such as obesity, type 2 diabetes, or liver disease. Possible therapeutic applications based on the components of this hepatic axis are discussed.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Endocrinology & Metabolism
Concetta Mastromauro, Cosimo Giannini, Francesco Chiarelli
Summary: Linear growth during childhood is the result of various factors, with the growth hormone-insulin-like growth factor axis playing a crucial role. Growth hormone insensitivity (GHI) is a significant disorder characterized by low IGF-1 levels, normal or elevated GH levels, and lack of IGF-1 response after GH administration. Recombinant IGF-1 preparations can be used for treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Stefano Cianfarani
Summary: GH therapy has shown excellent short-term safety, but long-term potential side effects remain a concern. Recent observational studies in different cohorts of young adult patients have yielded conflicting results, focusing on the risks of cancer, cardio and cerebrovascular diseases, and diabetes associated with GH therapy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Christopher J. Unterberger, Stephanie M. McGregor, John J. Kopchick, Steven M. Swanson, Paul C. Marker
Summary: This study using genetic knockout mouse models found that breast tumors are dependent on growth hormone signaling, suggesting the importance of the GH/IGF-1 axis in established mammary tumors.
Article
Environmental Sciences
Rui Yan, Jie Ding, Qianlei Yang, Xiaoyun Zhang, Junyu Han, Tingxu Jin, Shudi Shi, Xirui Wang, Yu Zheng, Heran Li, Hengdong Zhang, Yan An
Summary: This study investigated the skeletal toxicity of lead acetate (PbAc) in early life stages of zebrafish. The results showed that PbAc inhibited the differentiation and maturation of osteoblasts and cartilage matrix, promoted the formation of osteoclasts, disrupted the GH/IGF-1 axis, and ultimately induced cartilage defects and bone loss in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Endocrinology & Metabolism
Anja Apel, Daniel I. Iliev, Christina Urban, Karin Weber, Roland Schweizer, Gunnar Blumenstock, Sarah Pasche, Vanessa Nieratschker, Gerhard Binder
Summary: In patients treated with a normal dose of rhGH, the methylation of IGF1 P2 promoter was not significantly correlated with GH responsiveness, and the methylation of two key sites remained relatively stable during treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ana Isabel Martin, Teresa Priego, Alvaro Moreno-Ruperez, Daniel Gonzalez-Hedstrom, Miriam Granado, Asuncion Lopez-Calderon
Summary: Inflammation triggers a broad response from the neuroendocrine system, affecting all the endocrine axes, particularly the hypothalamic-growth hormone-insulin-like growth factor-1 axis. While the endocrine and metabolic responses to acute inflammation support organism survival, chronic inflammation contributes to catabolic processes leading to muscle wasting and weakness. The inhibition of the hypothalamic-GH-IGF-1 axis plays a role in this mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Martina Romanisio, Rosa Pitino, Alice Ferrero, Francesca Pizzolitto, Samuele Costelli, Valentina Antoniotti, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam, Marina Caputo
Summary: This study evaluated metabolic comorbidities in surgically treated acromegalic patients and found that the discrepancy between GH and IGF-1 levels does not appear to be a risk factor for their presence or persistence. Further extended studies are needed to confirm these results in the long term.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Manuel H. Aguiar-Oliveira, Roberto Salvatori
Summary: The study of isolated GH deficiency caused by a homozygous inactivating mutation in the GH releasing hormone receptor gene has shown a variety of phenotypic changes in body size and function, with a greater number of beneficial consequences.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Oncology
Mateusz Adamiak, Kamila Bujko, Arjun Thapa, Valentina Pensato, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Daryl L. Davies, Henning Ulrich, Magda Kucia, Mariusz Z. Ratajczak
Summary: Recent evidence suggests that extracellular adenosine triphosphate (eATP) plays a crucial role in regulating the mobilization and homing of hematopoietic stem progenitor cells (HSPCs) through activation of P2X4 and P2X7 receptors. Deficiency in either receptor impairs chemotaxis of HSPCs and affects their homing and engraftment post transplantation.
Article
Cell Biology
Yun Zhu, Yimin Fang, David Medina, Andrzej Bartke, Rong Yuan
Summary: Research suggests that early metformin treatment can have effects on development and metabolism in mice, including delayed sexual maturation in females, increased body weight and food consumption, increased tail length and IGF1 levels. Metformin alters insulin and insulin sensitivity in a sex-specific manner in mice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
Article
Biochemical Research Methods
Kamila Bujko, Andrzej K. Ciechanowicz, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Very small embryonic like stem cells (VSELs) are dormant stem cells deposited during embryogenesis in various tissues, including bone marrow. They are released and circulate in peripheral blood at a low level, but increase in number in response to stressors and tissue/organ damage. This study evaluates CD34(+)Lin(-)CD45(-) and CD133(+)Lin(-)CD45(-) VSELs derived from umbilical cord blood, comparing their molecular and proteomic characteristics.
Article
Oncology
Mariusz Z. Ratajczak, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Kamila Bujko, Arjun Thapa, Vira Chumak, Stephanie Franczak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia
Correction
Oncology
Alison Domingues, Elisa Rossi, Kamila Bujko, Gregoire Detriche, Ulysse Richez, Adeline Blandinieres, Magdalena Kucia, Janina Ratajczak, David M. Smadja, Mariusz Z. Ratajczak
Review
Andrology
Andrzej Bartke, Erin Hascup, Kevin Hascup
Summary: There is growing recognition that sex differences extend beyond reproductive organs and traits related to reproduction, and that sex is a significant biological variable in most characteristics of living organisms. This article focuses on sex differences in responses to anti-aging interventions, which have been shown to vary substantially between females and males. While calorie restriction and certain genetic alterations can extend longevity in both sexes, specific metabolic changes and health benefits differ between women and men. It is clear that understanding the unique mechanisms of aging in females and males is crucial for developing effective and tailored anti-aging interventions.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Cell & Tissue Engineering
Arjun Thapa, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Hematopoietic stem/progenitor cells (HSPCs) express receptors for complement cascade (ComC) cleavage fragments C3a and C5a and respond to inflammation-related cues by sensing PAMPs and DAMPs. The activation of Nox2-ROS-Nlrp3 inflammasome by ComC-derived C3a and C5a plays a role in regulating the responsiveness of HSPCs to stress. Additionally, ComC expressed in HSPCs, known as the complosome, may also contribute to regulating hematopoiesis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Ahmed Abdelbaset-Ismail, Katarzyna Brzezniakiewicz-Janus, Arjun Thapa, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak
Summary: The study reveals that hematopoietic stem progenitor cells (HSPCs) follow the diurnal circulation rhythm in peripheral blood and melatonin can inhibit the migration of HSPCs by inhibiting Nlrp3 inflammasome activation.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Ahmed Abdelbaset-Ismail, Andrzej K. Ciechanowicz, Kamila Bujko, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Proliferation, metabolism, and migration of hematopoietic stem/progenitor cells (HSPCs) are regulated by receptors integrated into membrane lipid rafts (MLRs). The synthesis of MLRs components in HSPCs is regulated by Nox2-ROS-Nlrp3 inflammasome axis, which modulates lipogenesis and the responsiveness of HSPCs to external stimuli.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Himi Tripathi, Alison Domingues, Renee Donahue, Audrey Cras, Coralie L. Guerin, Erhe Gao, Bryana Levitan, Mariusz Z. Ratajczak, David M. Smadja, Ahmed Abdel-Latif, Wadea M. Tarhuni
Summary: Ischemic heart disease, often caused by AMI, is a major cause of morbidity and mortality worldwide. The combination therapy of MSCs and ECFCs can reduce cardiomyocyte apoptosis, scar size, and adverse cardiac remodeling in a pre-clinical model of AMI. This approach shows promise for future human studies during the acute phase of ischemic cardiac injury.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Vira Chumak, Katarzyna Sielatycka, Andrzej Ciechanowicz, Kamila Bujko, Mariusz Z. Ratajczak, Magdalena Kucia
Summary: Very small embryonic-like stem cells (VSELs) are dormant stem cells in adult tissues that contribute to tissue/organ repair and regeneration. Proteomic analysis revealed that VSELs express proteins involved in development, signal transduction, and cellular functions, supporting their origin from reproductive lineage.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Arjun Thapa, Ahmed Abdelbaset-Ismail, Vira Chumak, Mateusz Adamiak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: We discovered that sterile inflammation in the bone marrow plays a crucial role in the mobilization, homing, and engraftment of hematopoietic stem/progenitor cells (HSCPs). Extracellular adenosine (eAdo), generated from the conversion of extracellular adenosine triphosphate (eATP), affects HSPCs trafficking by activating the A(2B) receptor. By upregulating heme oxygenase-1 (HO-1), an inhibitor of Nlrp3 inflammasome, the A(2B) receptor inhibition promotes cell migration and proliferation. Blocking the A(2B) receptor could potentially enhance HSPCs mobilization and hematopoietic reconstitution.
STEM CELL REVIEWS AND REPORTS
(2022)
Retraction
Cell & Tissue Engineering
Neeta Shirvaikar, Leah A. Marquez-Curtis, Mariusz Z. Ratajczak, Anna Janowska-Wieczorek
STEM CELLS AND DEVELOPMENT
(2022)
Article
Cell & Tissue Engineering
Mateusz Adamiak, Andrzej Ciechanowicz, Vira Chumak, Kamila Bujko, Janina Ratajczak, Katarzyna Brzezniakiewicz-Janus, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: This study reveals the importance of complement activation in the homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). The alternative pathway of complement cascade activation plays a role in this process. Deficiency of factor B leads to poor engraftment of HSPCs, possibly due to decreased expression of certain proteins involved in cell migration and immune system.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Cell & Tissue Engineering
Andrzej Bartke
Summary: Research on the biology of aging has shifted focus from studying the effects of aging to searching for mechanisms and interventions that can extend healthspan. The field emphasizes multiple physiological changes, nutrient-dependent signaling pathways, and the impact of age as a risk factor for chronic disease. Major advancements in technology and analysis have provided optimism for the development of safe and widely applicable anti-aging interventions in the near future.
STEM CELL REVIEWS AND REPORTS
(2022)