Review
Biochemistry & Molecular Biology
Filip Kolodziej, Brian McDonagh, Nicole Burns, Katarzyna Goljanek-Whysall
Summary: Oxidative stress and inflammation are associated with muscle function decline, but paradoxically, they are also important for adaptive responses to exercise. MicroRNAs play a key role in regulating skeletal muscle metabolism and phenotype. Regular aerobic exercise, accompanied by a healthy diet, can promote metabolic health and muscle hypertrophy through miRNA-mediated regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Marco Narici, Jamie McPhee, Maria Conte, Martino V. Franchi, Kyle Mitchell, Sara Tagliaferri, Elena Monti, Giuseppe Marcolin, Philip J. Atherton, Kenneth Smith, Bethan Phillips, Jonathan Lund, Claudio Franceschi, Marcello Maggio, Gillian S. Butler-Browne
Summary: The study introduced an ultrasound imaging method for diagnosing sarcopenia based on changes in muscle geometric proportions. The ultrasound sarcopenic index (USI) was proposed as a novel marker for the loss of muscle mass associated with sarcopenia, providing a useful 'signature of sarcopenia' and allowing for stratification of individuals according to muscle sarcopenia presence and severity. The USI was found to be a useful clinical tool for confirming the diagnosis of sarcopenia, with DXA-derived skeletal muscle index (SMI) showing significant correlation with USI.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Cell Biology
N. F. Shur, L. Creedon, S. Skirrow, P. J. Atherton, I. A. MacDonald, J. Lund, P. L. Greenhaff
Summary: In the UK, it is projected that by 2035, people over the age of 65 will make up 23% of the population, with those over 85 accounting for 5%. Ageing is associated with changes in muscle metabolism and structure, but it is unclear how much of these changes are due to aging itself or sedentary behavior. Research on aging, physical activity, and muscle health is crucial for understanding the aging process and improving overall well-being.
AGEING RESEARCH REVIEWS
(2021)
Article
Biology
Osvaldo Villa, Nicole L. Stuhr, Chia-an Yen, Eileen M. Crimmins, Thalida Em Arpawong, Sean P. Curran
Summary: This study identifies the evolutionarily conserved mitochondrial enzyme ALH-6/ALDH4A1 as a predictive biomarker for age-related changes in muscle health. Through Caenorhabditis elegans genetics and gene-wide association scanning, the research uncovers that loss-of-function mutations in alh-6 lead to the age-dependent loss of muscle health in C. elegans, while genetic variants in ALDH4A1 show associations with age-related muscle-related function in humans.
Article
Geriatrics & Gerontology
Zhigang Hu, Yufeng Tian, Xinyu Song, Fanjun Zeng, Ailan Yang
Summary: This study aimed to investigate the associations between household air pollution and muscle strength and sarcopenia in the Chinese older population. The results showed that using solid fuel for cooking and heating was associated with decreased muscle strength and mass, as well as an increased risk of sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Nutrition & Dietetics
Sian Robinson, Antoneta Granic, Avan Aihie Sayer
Summary: Sarcopenia, characterized by loss of muscle strength and mass, is common in older populations and associated with poorer health outcomes. Current understanding of its pathophysiology is incomplete, particularly the role of nutrition. More research is needed, particularly from well-characterized prospective cohorts, to inform dietary guidelines for promoting muscle health.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Jason Tallis, Sharn Shelley, Hans Degens, Cameron Hill
Summary: Obesity and aging have negative impacts on skeletal muscle function, with their combined effects yet to be thoroughly explored. Poor muscle function is associated with chronic diseases, poor quality of life, and all-cause mortality, highlighting the importance of studying and intervening in these effects for overall health and physical function.
Article
Nutrition & Dietetics
Sophie L. Mathewson, Adam L. Gordon, Kenneth Smith, Philip J. Atherton, Carolyn A. Greig, Bethan E. Phillips
Summary: This study found that habitual dietary intake did not explain the differences in muscle mass and strength parameters between young and older adults, suggesting that there may be other factors contributing to these differences. Larger sample size studies are needed to further investigate these relationships and potentially inform interventions against sarcopenia development.
Article
Geriatrics & Gerontology
Mary Ni Lochlainn, Ayrun Nessa, Alyce Sheedy, Rachel Horsfall, Maria Paz Garcia, Deborah Hart, Gulsah Akdag, Darioush Yarand, Samuel Wadge, Andrei-Florin Baleanu, Kevin Whelan, Claire Steves
Summary: This study aims to investigate the role of the gut microbiome in anabolic resistance to dietary protein in older adults by testing whether modulation of the gut microbiome using a prebiotic, in addition to protein supplementation, can improve muscle strength. The study is a randomised, double-blinded, placebo-controlled trial, with participants taking supplementation once daily for 12 weeks in addition to resistance exercises, with measures taken over video and questionnaires and cognitive testing conducted at the beginning and end of the study.
Review
Geriatrics & Gerontology
Hongfu Jin, Wenqing Xie, Peiwu Hu, Kun Tang, Xiuhua Wang, Yuxiang Wu, Miao He, Dengjie Yu, Yusheng Li
Summary: Sarcopenia is an age-related disease that significantly impacts the quality of life and prognosis of elderly individuals. Studies have shown that melatonin has potential in combating sarcopenia by protecting muscle cell mitochondria, maintaining muscle fiber numbers, and increasing muscle strength.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Navneet N. Lal, Jon Cornwall, Philip W. Sheard
Summary: This study aimed to develop a reliable assay for identifying denervated muscle fibers and explore the impact of denervation on age-related force-generation in mouse skeletal muscle. By injecting fluorescent deoxyglucose analog 2-NBDG and stimulating the tibial nerve, the researchers labeled active muscle fibers and collected data on muscle force generation. The results showed that aged muscles had more denervated fibers, increased passive force, and decreased specific force, but denervation only partly explained the age-related deficits in specific force. Further investigations are necessary to identify other contributors to the decrease in force generation.
Article
Biochemistry & Molecular Biology
Siti Liyana Saud Gany, Jen Kit Tan, Kok Yong Chin, Nur Haleeda Hakimi, Nazirah Ab Rani, Nurhazirah Ihsan, Suzana Makpol
Summary: Ageing leads to a gradual decrease in muscle mass and function, but tocotrienol-rich fraction (TRF) supplementation can protect against age-associated chronic diseases and metabolic disorders. This study found that TRF treatment improved muscle metabolomes and metabolic pathways in ageing rats, promoting amino acid synthesis and muscle regeneration.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Geriatrics & Gerontology
Jessica Cegielski, Joseph J. Bass, Ruth Willott, Adam L. Gordon, Daniel J. Wilkinson, Ken Smith, Philip J. Atherton, Bethan E. Phillips
Summary: This study investigates how different definitions influence the prevalence of sarcopenia in older adults. The results show that the prevalence varies greatly depending on the criteria used, such as muscle mass, gait speed, and handgrip strength.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
M. Farrow, J. Biglands, S. F. Tanner, A. Clegg, L. Brown, E. M. A. Hensor, P. O'Connor, P. Emery, A. L. Tan
Summary: The study found that younger participants had lower muscle MRI values of T2, FF, and mean diffusivity compared to middle-aged and older participants, while younger participants also exhibited higher muscle power and volume than middle-aged and older participants. Quantitative MRI measurements were correlated with frailty index, gait speed, grip strength, and muscle power, indicating that MRI can be used to detect muscle differences due to ageing and identify differences across age groups within muscle.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Jolan Dupont, Leen Antonio, Lenore Dedeyne, Terence W. O'Neill, Dirk Vanderschueren, Giulia Rastrelli, Mario Maggi, Gyorgy Bartfai, Felipe F. Casanueva, Aleksander Giwercman, Jolanta Slowikowska-Hilczer, Margus Punab, Ilpo T. Huhtaniemi, Frederick C. W. Wu, Jos Tournoy, Katrien Koppo, Evelien Gielen
Summary: In middle-aged and older men, inflammatory markers hs-CRP and WBC were negatively associated with QoL and PASE scores, while WBC was negatively associated with gait speed and knee strength. However, baseline inflammatory markers (hs-CRP, WBC, and albumin) did not predict functional decline, decline in physical activity, decreased QoL, or incident sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Letter
Oncology
Mario Redondo, Javier S. Morales, Alejandro Lucia, Isabel Prieto
CANCER CAUSES & CONTROL
(2020)
Article
Genetics & Heredity
Alfonsina Ballester-Lopez, Emma Koehorst, Miriam Almendrote, Alicia Martinez-Pineiro, Giuseppe Lucente, Ian Linares-Pardo, Judit Nunez-Manchon, Nicolau Guanyabens, Antoni Cano, Alejandro Lucia, Gayle Overend, Sarah A. Cumming, Darren G. Monckton, Teresa Casadevall, Irina Isern, Josep Sanchez-Ojanguren, Albert Planas, Agusti Rodriguez-Palmero, Laura Monlleo-Neilai, Guillem Pintos-Morell, Alba Ramos-Fransi, Jaume Coll-Canti, Gisela Nogales-Gadea
Article
Sport Sciences
Pedro L. Valenzuela, Yago Alcalde, Jaime Gil-Cabrera, Eduardo Talavera, Alejandro Lucia, David Barranco-Gil
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2020)
Article
Sport Sciences
Javier S. Morales, Elena Santana-Sosa, Alejandro Santos-Lozano, Antonio Bano-Rodrigo, Pedro L. Valenzuela, Cecilia Rincon-Castanedo, David Fernandez-Moreno, Marta Gonzalez Vicent, Marta Perez-Somarriba, Luis Madero, Alvaro Lassaletta, Carmen Fiuza-Luces, Alejandro Lucia
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Article
Pediatrics
Julio Alvarez-Pitti, Jose A. Casajus Mallen, Rosaura Leis Trabazo, Alejandro Lucia, Diego Lopez de Lara, Luis A. Moreno Aznar, Gerardo Rodriguez Martinez
ANALES DE PEDIATRIA
(2020)
Editorial Material
Sport Sciences
Adrian Castillo-Garcia, Huseyin Naci, Pedro L. Valenzuela, Maximilian Salcher-Konrad, Sofia Dias, Manuel R. Blum, Samali Anova Sahoo, David Nunan, Javier S. Morales, Alejandro Lucia, John P. A. Ioannidis
BRITISH JOURNAL OF SPORTS MEDICINE
(2020)
Review
Oncology
Cecilia Rincon-Castanedo, Javier S. Morales, Asuncion Martin-Ruiz, Pedro L. Valenzuela, Manuel Ramirez, Alejandro Santos-Lozano, Alejandro Lucia, Carmen Fiuza-Luces
CANCER AND METASTASIS REVIEWS
(2020)
Review
Oncology
Javier S. Morales, Pedro L. Valenzuela, Alba M. Herrera-Olivares, Cecilia Rincon-Castanedo, Asuncion Martin-Ruiz, Adrian Castillo-Garcia, Carmen Fiuza-Luces, Alejandro Lucia
CANCER AND METASTASIS REVIEWS
(2020)
Article
Engineering, Biomedical
Javier Milagro, David Hernando, Jesus Lazaro, Jose A. Casajus, Nuria Garatachea, Eduardo Gil, Raquel Bailon
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2020)
Article
Geriatrics & Gerontology
Javier Ortiz-Alonso, Natalia Bustamante-Ara, Pedro L. Valenzuela, Maite Vidan-Astiz, Gabriel Rodriguez-Romo, Jennifer Mayordomo-Cava, Marianna Javier-Gonzalez, Mercedes Hidalgo-Gamarra, Myriel Lopez-Tatis, Maria Isabel Valades-Malagon, Alejandro Santos-Lozano, Alejandro Lucia, Jose Antonio Serra-Rexach
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2020)
Review
Sport Sciences
Alberto Calleja-Romero, German Vicente-Rodriguez, Nuria Garatachea
Summary: Running a long-distance race has a considerable acute effect on the autonomic nervous system, hemodynamics, and vascular properties, with a decrease in markers of parasympathetic activity, blood pressure, and arterial stiffness.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Hospitality, Leisure, Sport & Tourism
I Lopez-Laval, S. Sitko, N. Garatachea, J. Calleja-Gonzalez, F. Corbi, R. Cirer-Sastre
Summary: This study investigated the relationship between mood states and performance among professional basketball players. The results showed that mood, energy index, and game performance remained stable throughout the competitive period. Additionally, starting players had higher mood scores compared to rotation players, and there was a positive relationship between pre-match mood assessment and competition performance. However, no relationship was found between player's performance and mood 48 hours after the game.
INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY
(2022)
Article
Environmental Sciences
Adrian Hernandez-Vicente, Jorge Marin-Puyalto, Esther Pueyo, German Vicente-Rodriguez, Nuria Garatachea
Summary: This study compared and described physical activity characteristics in centenarians at the end of human lifespan using different accelerometer metrics. The results suggest that cut-point-free metrics may provide a better description of physical activity levels in centenarians.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Sebastian Sitko, Rafel Cirer-Sastre, Nuria Garatachea, Isaac Lopez-Laval
Summary: This study aimed to describe the anthropometric differences and assess their correlation with physiological markers among road cyclists of different performance levels. The results showed that there were no significant anthropometric differences between trained, well trained, and professional cyclists, with only recreationally trained cyclists exhibiting larger perimeters and skinfolds than professional cyclists. Additionally, physiological performance did not distinguish between cyclists of different specialties, indicating restrained correlations with anthropometric values.
APPLIED SCIENCES-BASEL
(2023)
Article
Physiology
Kike Aztarain-Cardiel, Isaac Lopez-Laval, Luis A. Marco-Contreras, Jorge Sanchez-Sabate, Nuria Garatachea, Fernando Pareja-Blanco
Summary: The purpose of this study was to analyze the effects of plyometric training direction on jumping, sprinting, and change-of-direction ability in basketball players. The results showed that combining vertical and horizontal jumps induced improvements in more capabilities than training only vertical or horizontal jumps with the same training volume.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)