Article
Pharmacology & Pharmacy
Xue-Fei Hu, Hong Zhang, Ling-Ling Yu, Wen-Qiang Ge, Ou-Yang Zhan-mu, Yan-Zhen Li, Chao Chen, Teng-Fei Hou, Hong-Chun Xiang, Yuan-Heng Li, Yang-Shuai Su, Xiang-Hong Jing, Jie Cao, Hui-Lin Pan, Wei He, Man Li
Summary: The therapeutic effects of electroacupuncture (EA) on visceral pain and anxiety comorbidity in patients with inflammatory bowel disease (IBD) is well known. This study investigated the involvement of the ventral hippocampus (vHPC) and the cannabinoid type 1 receptors (CB1R) in the mechanism of EA's effects on anxiety and pain. The results demonstrated that EA alleviated visceral hyperalgesia and anxiety in IBD mice by reducing the expression of CB1R in GABAergic neurons and activating CB1R in glutamatergic neurons in the vHPC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Daniel R. Knight, Korakrit Imwattana, Brian Kullin, Enzo Guerrero-Araya, Daniel Paredes-Sabja, Xavier Didelot, Kate E. Dingle, David W. Eyre, Cesar Rodriguez, Thomas Riley
Summary: Research on over 12,000 C. difficile genomes revealed major taxonomic incoherence and clear species boundaries for the recently described cryptic clades CI-III. This discovery has significant implications for the global population structure of C. difficile and the Peptostreptococcaceae taxonomy as a whole. Additionally, the unique toxin gene architecture of these newly identified genomospecies may impact the diagnosis of CDI.
Article
Neurosciences
Robert J. Pawlik, Liubov Petrakova, Lisa Brotte, Harald Engler, Sven Benson, Sigrid Elsenbruch
Summary: This study investigated the relationship between pro-inflammatory cytokines and visceral sensitivity in healthy individuals, finding that systemic cytokine levels do not contribute significantly to interindividual variability in visceroception.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Anesthesiology
Oana Bucsea, Mohammed Rupawala, Ilana Shiff, Xiaogang Wang, Judith Meek, Maria Fitzgerald, Lorenzo Fabrizi, Rebecca Pillai Riddell, Laura Jones
Summary: In neonates, there is an inconsistent relationship between pain-related facial expression changes and brain activity. This study investigates whether subclinical or clinically significant levels of pain-related facial activity are associated with differences in the pattern of nociceptive brain activity in preterm and term neonates.
Article
Geriatrics & Gerontology
Derek D. Satre, Varada Sarovar, Wendy A. Leyden, Amy S. Leibowitz, Jennifer O. Lam, J. Carlo Hojilla, Thibaut Davy-Mendez, Charles B. Hare, Michael J. Silverberg
Summary: This study compared patient-reported outcomes and HIV viral control among people living with HIV (PWH) in different age groups (18-34, 35-44, 45-54, >= 55 years old) who were enrolled in a primary care-based behavioral alcohol intervention trial. The results showed that older PWH had less substance use but experienced limited social support and worse physical quality of life. In addition, younger PWH had lower antiretroviral therapy adherence and higher odds of unhealthy alcohol use, tobacco, cannabis, or other substances compared to older PWH.
AGING & MENTAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Sergio Lopez-Estevez, Monica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martinez
Summary: This study found that sigma 1Rs are involved in the development of acute colitis and its associated hypersensitivity. Selective modulation of sensory-related pathways within the colon and spinal cord may be part of the underlying mechanism.
Article
Neurosciences
Le Guan, Yang Liu, Bin Wu, Aiqin Chen, Wucheng Tao, Chun Lin
Summary: This study analyzed global research trends in visceral pain over the past 40 years through visual analysis. The research found that visceral pain-related studies have received increasing attention, but there are still many unresolved issues that require further research. The study concludes that the molecular mechanisms and clinical treatments of visceral pain, as well as issues related to inflammation, inflammatory bowel disease, irritable bowel syndrome, anxiety, and quality of life, need to be further explored.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Yenisel Cruz-Almeida, Stephen Coombes, Marcelo Febo
Summary: NODDI imaging technique revealed lower neurite density and less geometric complexity in older adults with chronic musculoskeletal pain. The lower neurite density was associated with higher pain intensity and anatomical pain sites. Pain-by-sex differences in neurite density and geometric complexity were also observed.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Antonio Granero, Gabriel Anaya, Maria J. Alcalde
Summary: This study examines the morphometric differences in different historical genetic lines of the Spanish Merino sheep breed. The results show significant differences in measurements and indexes between the genetic lines, suggesting how different lines have developed due to management models and adaptation to specific ecosystems. The study complements previous genomic research and highlights the importance of preserving the genetic variability of the original Spanish Merino breed.
Article
Environmental Sciences
Amira Abozaid, Robert Gerlai
Summary: Anxiety is a significant medical need, but current pharmacotherapy options are often ineffective. The zebrafish has emerged as a promising animal model for studying anxiolytic drugs. This study investigated the effects of buspirone hydrochloride on zebrafish behavior and found that it reduced movement and thigmotaxis while increasing immobility duration and turn angle. These findings suggest that juvenile zebrafish could be a useful model for evaluating the effects of anxiolytic drugs.
Article
Plant Sciences
Yi-Bo Chen, Yu-Chao Chen, Yu-Xing Zhu, Sai Li, Hua-bing Deng, Jiu-Rong Wang, Wen-Bang Tang, Liang Sun
Summary: Rice, a staple crop for nearly half the global population, tends to absorb excessive cadmium when grown in contaminated fields. Different rice varieties show genetic diversity in cadmium distribution and tolerance, with potential implications for genetic improvement. This study identified multiple QTLs for cadmium distribution and tolerance, revealing the complex genetic control mechanisms in rice.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Anesthesiology
Timothy M. Baran, Feng Lin, Paul Geha
Summary: Low back pain is a common and disabling condition in older adults. The cause of this chronic pain condition in older adults is unknown. This study explores the role of brain activity patterns in the emergence and experience of low back pain, and how these patterns differ between age groups. The results suggest that limbic brain areas play an increased role in older patients with low back pain.
Article
Neurosciences
Shunchang Fang, Yuxin Qin, Shana Yang, Hongyang Zhang, Jieyan Zheng, Songhai Wen, Weimin Li, Zirui Liang, Xiaomin Zhang, Boxing Li, Lianyan Huang
Summary: Both acute and persistent pain are associated with anxiety, but the neural mechanisms underlying them differ. This study found that both types of pain induced anxiety-like behavior in mice, and different brain regions and gene expression patterns were involved in acute and persistent pain-related anxiety-like behaviors.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Zuqi Shen, Wei Li, Weiqi Chang, Na Yue, Jin Yu
Summary: Mental disorders induced by chronic pain, such as anxiety and depression, are common in clinical practice, and there are significant sex differences in their epidemiology. However, the circuit mechanism of this difference has not been fully studied. Recently, studies including male and female rodents have revealed sex differences in the neurobiological processes behind mental disorder features.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Engineering, Multidisciplinary
Yuxiao Chang, Xiang Li, Lei Ding, Chao Yang, Zhiyuan Pan, Ni Han, Yujun Cui, Fachao Zhi, Ruifu Yang, Hong Gao, Yujing Bi
Summary: This study used culturomics to isolate Escherichia coli strains from colorectal cancer (CRC) mucosal samples and investigated their genomic and functional differences. The strains were divided into five phylogroups based on genomic comparison and were found to induce different levels of cytokine secretion. The analysis also revealed distinct profiles of single-nucleotide polymorphisms, genes, and metabolic pathways in the different phylogroups, highlighting the importance of studying microbiota function at the strain level for understanding host-bacteria interactions.