期刊
AGE
卷 35, 期 1, 页码 197-205出版社
SPRINGER
DOI: 10.1007/s11357-011-9326-1
关键词
Blood pressure; TNF-alpha; Leucocyte adhesion; CD11b/18; Ageing; BELFAST study
Hypertension, a key risk factor for stroke, cardiovascular disease and dementia, is associated with chronic vascular inflammation, and although poorly understood, putative mechanisms include pro-inflammatory responses induced by mechanical stretching, with cytokine release and associated up-regulated expression of adhesion molecules. Because blood pressure increases with age, we measured baseline and tumour necrosis alpha (TNF-alpha)-stimulated CD11b/CD18 adhesion molecule expression on leucocytes to assess any association between the two. In 38 subjects (mean age 85 years), consecutively enrolled from Belfast Elderly Longitudinal Free-Living Aging Study (BELFAST), baseline and TNF-alpha-stimulated CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure > 120 mmHg (p = 0.05) and for lymphocytes, with diastolic blood pressure > 80 mmHg (p < 0.05).These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-alpha, and suggest mechanistic reasons why better hypertension control is important.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据