Article
Biology
Alexey Fayzullin, Natalia Ignatieva, Olga Zakharkina, Mark Tokarev, Daniil Mudryak, Yana Khristidis, Maxim Balyasin, Alexandr Kurkov, Semyon Churbanov, Tatyana Dyuzheva, Peter Timashev, Anna Guller, Anatoly Shekhter
Summary: Understanding scar maturation is essential for developing better treatment and diagnostics. Current experimental models mainly focus on the early stages of scar development, lacking research on older scars. The new rabbit model introduced in this study provides a foundation for studying mature hypertrophic scars.
Article
Immunology
Evangelos Papathanasiou, Andrew R. Scott, Carroll Ann Trotman, Corinna Beale, Lori Lyn Price, Gordon S. Huggins, Yang Zhang, Irene Georgakoudi, Thomas E. Van Dyke
Summary: This preclinical experimental study evaluated the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A(4) (LXA(4)-ME) on scarring in a novel rabbit model of cleft lip repair. The results showed that LXA(4)-ME can reduce inflammation, decrease scar formation, and improve wound healing outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haisheng Lin, Zhihong Zheng, Jianjun Yuan, Chaohua Zhang, Wenhong Cao, Xiaoming Qin
Summary: Marine collagen peptides derived from Sipunculus nudus (SNCP) have been found to promote skin wound healing by reducing inflammation, improving collagen deposition and recombination, and blocking the TGF-β/Smads signaling pathway, thus inhibiting scar formation. The study demonstrated that SNCP accelerates wound healing, induces cell proliferation and migration, and exhibits scar-free healing effects, suggesting potential clinical applications in skin wound repair and scar inhibition.
Article
Multidisciplinary Sciences
Mengwei Han, Luni Hu, Di Wu, Yime Zhang, Peng Li, Xingyu Zhao, Yanyu Zeng, Guanqun Ren, Zhiyuan Hou, Yanli Pang, Tongbiao Zhao, Chao Zhong
Summary: This study characterizes the differentiation and activation of uterine trNK cells during pregnancy, revealing a mechanism involving IL-21R-STAT3 axis and an apoptotic program to control their functionality and avoid tissue damage.
NATURE COMMUNICATIONS
(2023)
Review
Engineering, Biomedical
Rachel Chapla, Jennifer L. West
Summary: Biomaterials can be intentionally designed to support vascularization by mimicking cell-matrix and signaling biomolecule interactions. Hydrogels, frequently used in these applications, have mechanical properties similar to soft tissues and can promote vasculature formation in vivo through specific cell-material interactions. The design of hydrogels tailored for supporting vascularization involves considerations of mechanical properties, biodegradation, cell adhesive interactions, biochemical signaling, and architectural properties.
PROGRESS IN BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Aneta Prokopova, Jana Pavlackova, Pavel Mokrejs, Robert Gal
Summary: The study showed that a cosmetic gel formulation enriched with chicken collagen hydrolysate can significantly improve skin hydration, elasticity, and wrinkles in the periorbital area. The longer the formulation is applied, the better the results, benefiting from the biocompatibility and biodegradability of the product.
Article
Geriatrics & Gerontology
Jun Huang, Jun Chen, Yan Wo, Xue Wang, Yixin Zhang, Xiangdong Chen, Zhen Zhang, Ewelina Biskup
Summary: The combined treatment of CO(2) fractional laser and 5-FU EG showed better therapeutic effects on rabbit HS model compared to 5-FU EG alone, mainly by inhibiting the expression of collagen I/III and TGF-beta 1 to improve scars.
REJUVENATION RESEARCH
(2021)
Review
Agriculture, Dairy & Animal Science
Ana Zapata, Rocio Fernandez-Parra
Summary: Undenatured type II collagen and Boswellia serrata are effective feed supplements for managing osteoarthritis (OA), improving symptoms and enhancing joint mobility. However, further research is needed to determine their preventive effects. Nonetheless, these supplements are considered valid options for managing OA and improving activity levels in dogs.
Review
Surgery
Nawal Khan, Dominique Willette, Jacklyn Melkonian, Mary Ziegler, Alan D. Widgerow
Summary: Currently, there is a lack of standardized methods to evaluate patient satisfaction after postauricular reconstruction. Patients showed lower satisfaction with the tragus and antitragus. It is necessary to incorporate a standardized surgery-specific questionnaire to assess patient satisfaction.
FACIAL PLASTIC SURGERY & AESTHETIC MEDICINE
(2022)
Article
Dermatology
Alan D. Widgerow, Mary E. Ziegler, John A. Garruto, Deanne Mraz Robinson, Melanie D. Palm, Janelle H. Vega, Michaela Bell
Summary: This study identified a group of active agents that stimulated the production of high molecular weight HA and proposed a novel approach to HA topical application with exclusively high molecular weight HA production. Through testing, this method can maximize hydration capacity and promote regenerative activity within the skin matrix.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Deanne Mraz Robinson, Janelle Vega, Melanie D. Palm, Michaela Bell, Alan D. Widgerow, Alessia Giannini
Summary: This study evaluated the efficacy and safety of a new hyaluronic acid serum formulation on facial skin. The results demonstrate significant improvements in skin hydration and received positive ratings from participants and investigators.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Surgery
Jeremy A. Lombardo, Derek A. Banyard, Alan D. Widgerow, Jered B. Haun
Summary: The authors designed and fabricated two new devices (EMD and FD) to replace the traditional manual nanofat preparation method. The results showed significant improvement in the enrichment and quantity of adipose-derived stem cells using EMD and FD compared to traditional nanofat. Future work will focus on investigating the wound healing response in vitro and in vivo, and refining the technology for automated operation in clinical settings.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Mary E. Ziegler, Alexandria M. Sorensen, Derek A. Banyard, Lohrasb R. Sayadi, Evangelia Chnari, Michaela M. Hatch, Jade Tassey, Yeva Mirzakhanyan, Paul D. Gershon, Christopher C. W. Hughes, Gregory R. D. Evans, Alan D. Widgerow
Summary: Combining fascia matrix with autologous fat grafting can enhance angiogenesis and adipogenesis, improving the long-term retention of fat tissue.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dermatology
Mara Weinstein Velez, James Prezzano, Michaela Bell, Alan Widgerow
Summary: This study found that adjuvant topical therapy can impact the healing process and outcome of patients treated with fractional laser for acne scarring. The use of Regenerating Skin Nectar with TriHex Technology (RSN) significantly decreased postprocedural transepidermal water loss (TEWL) and erythema, and increased aesthetic improvement in acne scars and patient satisfaction.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Biochemical Research Methods
Pavan Baichan, Previn Naicker, Tanya Nadine Augustine, Martin Smith, Geoffrey Candy, John Devar, Ekene Emmanuel Nweke
Summary: This study aimed to identify dysregulated proteins in South African GBC patients, providing insights into the molecular mechanisms and potential biomarkers of the disease. Through proteomic profiling of tissue and plasma samples, several proteins were found to be aberrantly expressed in GBC patients, suggesting their potential utility as biomarkers.
CLINICAL PROTEOMICS
(2023)
Article
Surgery
Mary E. Ziegler, Kameel Khabaz, Nima Khoshab, Faris F. Halaseh, Evangelia Chnari, Siwei Chen, Pierre Baldi, Gregory R. D. Evans, Alan D. Widgerow
Summary: Combining superficial adipose fascia matrix with AAM improves volume retention, adipogenesis and angiogenesis. The combined matrices trigger angiogenesis and proregenerative signals, making this bioscaffold worthy of further investigation.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Orthopedics
Mary E. Ziegler, Andres Staben, Melinda Lem, Jason Pham, Leonardo Alaniz, Faris F. Halaseh, Sabine Obagi, Amber Leis, Alan D. Widgerow
Summary: The study demonstrates that DMFs can be transformed into adipocytes through co-culture with PRP and ASCs, leading to reduced fibrosis in vivo.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2023)
Article
Dermatology
Alan D. Widgerow, Mary E. Ziegler, John A. Garruto, Faiza Shafiq
Summary: This paper describes the research and validation process of a novel antioxidant product. The results show that the new formulation has equivalent antioxidant capacity to a leading product on the market, and it also has a positive effect on elastin preservation compared to existing variations. The findings validate the use of a sodium salt derivative in the formulation and support the overall regenerative effects of the technology used in other products.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Surgery
Jagmeet S. Arora, Joshua K. Kim, Mikhail Pakvasa, Lohrasb R. Sayadi, Melinda Lem, Alan D. Widgerow, Amber R. Leis
Summary: This study investigated the effects of retained microsurgical needles on health and neurovascular compromise using an animal model. The results showed that the retention of 9.0 and 8.0 needles in rats did not cause any harm to their health or neurovascular structures. Imaging for needles smaller than 8.0 may be futile.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Review
Dermatology
Nawal Khan, Faris F. Halaseh, Kathryn Pillai, Daniel P. Zaki, Lohrasb R. Sayadi, Alan D. Widgerow
Summary: This review evaluates the effectiveness of two commonly used oxygen delivery methods, hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT), for the treatment of thermal burn wound healing. The results show that HBOT has positive effects on the healing of burn wounds and associated complications, while the effectiveness of TOT remains poorly investigated.
JOURNAL OF WOUND CARE
(2023)
Article
Dermatology
Amir Moradi, Faiza Shafiq, Tiffany Robison, Lora Colvan, Jeannette Poehler, Alan D. Widgerow
Summary: This study validates the efficacy and tolerability of a new antioxidant serum for addressing facial photodamage. The results show significant improvements in all evaluated facial photodamage parameters after 12 weeks of treatment, along with excellent tolerability and subject satisfaction. Histological findings indicate increased elastin fibers and stimulation of collagen production.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Dermatology
Alan D. Widgerow, Jordan V. Wang, Mary E. Ziegler, Sabrina G. Fabi, John A. Garruto, Deanne Mraz Robinson, Michaela Bell
Summary: This study provides a comprehensive scientific narrative on various factors related to skin pigmentation, and identifies new active agents for the treatment of hyperpigmentation.
JOURNAL OF DRUGS IN DERMATOLOGY
(2022)
Review
Surgery
S. J. Grossberg, J. D. Brener, E. L. Bizos, G. P. Candy, D. B. Bizos
Summary: This study aimed to investigate the changes in negative appendicectomy rate (NAR) over the past decade. The study found a significant decline in the overall NAR, with higher NAR in females and females under the age of 45. Recent imaging examinations were helpful in diagnosing appendicitis.
SOUTH AFRICAN JOURNAL OF SURGERY
(2022)