Article
Cardiac & Cardiovascular Systems
Daniel Bos, Banafsheh Arshi, Quirijn J. A. van den Bouwhuijsen, M. Kamran Ikram, Mariana Selwaness, Meike W. Vernooij, Maryam Kavousi, Aad van der Lugt
Summary: This study found that hemorrhage in carotid atherosclerotic plaque is an independent risk factor for stroke and coronary heart disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Panagiotis Tsioufis, Panagiotis Theofilis, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary atherosclerosis is a chronic disease involving inflammation, endothelial dysfunction, and lipoprotein dysregulation. Inflammatory cytokines, such as interleukins, tumor necrosis factor-alpha, and chemokines, play a role in the development and progression of coronary artery disease. Targeting these cytokines with drugs like IL-1 beta and colchicine has shown promise in reducing cardiovascular risk. Other cytokine-targeted treatments are being explored, but more research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Daniela Flores-Gomez, Siroon Bekkering, Mihai G. Netea, Niels P. Riksen
Summary: Atherosclerosis is characterized by persistent inflammation in the arterial wall, where trained immunity of the innate immune system may play a crucial role in its pathophysiology. This mechanism offers exciting novel pharmacological targets for the prevention or treatment of cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Lasse G. Lorentzen, Gorm M. Hansen, Kasper K. Iversen, Henning Bundgaard, Michael J. Davies
Summary: Proteomic analysis of proteins captured on angioplasty balloons during percutaneous coronary interventions can provide information on coronary artery lesion protein profiles and distinguish between different types of coronary artery disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Fangpu Yu, Ya Zhang, Zunzhe Wang, Weigang Gong, Cheng Zhang
Summary: This study identified the role of hsa_circ_0030042 in regulating abnormal autophagy of endothelial cells and plaque stability via modulating eIF4A3. This new pathway may serve as a potential therapeutic strategy against cardiovascular diseases like coronary heart disease.
Review
Cardiac & Cardiovascular Systems
Yan Zhou, Xueping Zhu, Hanming Cui, Jingjing Shi, Guozhen Yuan, Shuai Shi, Yuanhui Hu
Summary: The VEGF family, known for its role in regulating blood and lymphatic vessels, shows promise for treating coronary heart disease (CHD) by regulating various functions such as angiogenesis, apoptosis, inflammation, and fibrogenesis. Through binding with different receptors, VEGF proteins can modulate distinct physiological processes, offering potential pathways for treating CHD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Luke P. Dawson, Mark Lum, Nitesh Nerleker, Stephen J. Nicholls, Jamie Layland
Summary: Advancements in treatments aimed at reducing cardiovascular events have been paralleled by improvements in coronary imaging modalities to assess plaque volumes and composition. Studies aiming to demonstrate plaque regression and improvements in high-risk features have potential to reduce cardiovascular events in the future.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mustafa Yalcinkaya, Panagiotis Fotakis, Wenli Liu, Kaori Endo-Umeda, Huijuan Dou, Sandra Abramowicz, Tong Xiao, Peter Libby, Nan Wang, Alan R. Tall, Marit Westerterp
Summary: This study reveals that IL-1β derived from macrophages promotes neutrophil extracellular trap formation in atherosclerotic plaques. This effect is achieved by increasing neutrophil accumulation in plaques and promoting neutrophil NLRP3 inflammasome activation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Endocrinology & Metabolism
Tianci Yao, Weilin Lu, Jinshan Ke, Hao Zhang, Xiaofang Zhao, Bei Song, Ting Liu, Qinmei Ke, Chengyun Liu
Summary: Elevated apoB levels are associated with the severity and residual risk of coronary atherosclerotic heart disease in participants with statin treatment, while elevated LDL-C levels are not significantly associated with these outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Diede Smeets, Anton Gistera, Stephen G. Malin, Dimitrios Tsiantoulas
Summary: B cells play a crucial role in the pathophysiology of atherosclerotic cardiovascular disease, with both protective and harmful functions. Their unique ability to produce and secrete antigen-specific antibodies that can have effects at distant sites is a key factor in the development of atherosclerosis. The atherogenic environment can impact the homeostasis, differentiation, and antibody production of B cells, but it is unclear if their responses are directed by atherosclerosis-specific antigens. Understanding the full spectrum of B cell properties in atherosclerosis is essential for developing innovative therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Xiaoxing Hu, Huiping Tong
Summary: Dynamic electrocardiograms have a higher positive detection rate and better diagnostic effectiveness in diagnosing arrhythmic coronary atherosclerotic heart disease compared to conventional electrocardiograms.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yoshimi Kishimoto, Kazuo Kondo, Yukihiko Momiyama
Summary: Sestrin2, an anti-oxidant protein induced by various stresses, plays a protective role against oxidative damage and may serve as a potential therapeutic target for the treatment of atherosclerosis. High blood sestrin2 levels in patients with atherosclerotic diseases may reflect a compensatory response to increased oxidative stress, aiding in the protection against disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Laurentiu Braescu, Marinica Gaspar, Darius Buriman, Oana Maria Aburel, Adrian-Petru Merce, Felix Bratosin, Klokov Sergei Aleksandrovich, Satish Alambaram, Cristian Mornos
Summary: The secretory function of epicardial fat plays an important role in the development of coronary artery disease, as it can cause metabolic disturbances at the level of the cardiac muscle via secretion products, thus increasing the risk of coronary heart disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ahmed Hassaan Qavi, Guohai Zhou, Rachel E. Ward, John Jeffrey Carr, R. Curtis Ellison, Donna K. Arnett, J. Michael Gaziano, Luc Djousse
Summary: This study found no significant association between baked/mashed potato consumption and calcified atherosclerotic plaques in the coronary arteries in older adults.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Tamar Vakhtangadze, Rajeeka Singh Tak, Utkarsh Singh, Mirza S. Baig, Evgeny Bezsonov
Summary: Cardiovascular diseases are a major cause of death and morbidity worldwide, affecting both men and women, with gender-related differences observed in mortality and morbidity rates across different age groups. Ischemic heart disease, heart failure, systemic hypertension, and valvular heart disease are common forms of CVD, predominantly caused by atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)