期刊
ADVANCES IN SPACE RESEARCH
卷 41, 期 5, 页码 816-823出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.asr.2007.10.016
关键词
spaceflight; microgravity; myosin heavy chain; paramyosin; C. elegans; mutation
We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function. (c) 2007 COSPAR. Published by Elsevier Ltd. All rights reserved.
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