Article
Food Science & Technology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea Toft Hansen, Joanne A. Harrold, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: This study examines the relationship between changes in circulating metabolites during diet-induced weight loss and changes in adiposity, finding significant associations between lipid species and citric acid with body weight and adiposity reduction. The results also show that changes in lysophosphatidylcholines and citric acid concentrations during weight loss are linked to adiposity regain and loss during the maintenance period, highlighting the importance of adipose lipid metabolism in weight and adiposity maintenance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Gal Tsaban, Anat Yaskolka Meir, Hila Zelicha, Ehud Rinott, Alon Kaplan, Aryeh Shalev, Amos Katz, Dov Brikner, Matthias Bluher, Uta Ceglarek, Michael Stumvoll, Meir J. Stampfer, Iris Shai
Summary: This study found that lower fasting ghrelin levels were associated with unfavorable cardiometabolic parameters during weight loss. After 18 months of weight loss, the increase in fasting ghrelin levels differed between different diet groups, with the green-MED diet group showing the highest increase. In addition, the increase in fasting ghrelin levels among men was associated with improved insulin sensitivity and regression of visceral adipose tissue.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Man Liu, Hong Liu, Feng Feng, An Xie, Gyeoung-Jin Kang, Yang Zhao, Cody R. Hou, Xiaoxu Zhou, Samuel C. Dudley
Summary: Magnesium deficiency can cause reversible diastolic cardiomyopathy associated with mitochondrial dysfunction and oxidative modificaton of cMyBPC. Magnesium supplementation may represent a novel treatment for diastolic heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Cristina Tejera, Cristina Porca, Gemma Rodriguez-Carnero, Paula Andujar, Felipe F. Casanueva, Diego Bellido, Ana B. Crujeiras
Summary: Metabolic syndrome (MetS) increases the risk of cardiovascular disease, type 2 diabetes mellitus, and cancer. This study aimed to investigate the effectiveness of an intensive lifestyle program in reducing the prevalence of MetS in adults with obesity. The results showed that implementation of the IGOBE program resulted in a significant reduction in MetS prevalence and better control of MetS features compared with the standard of care.
Article
Nutrition & Dietetics
Federica Vinciguerra, Luigi Piazza, Carla Di Stefano, Claudia Degano, Alfredo Pulvirenti, Roberto Baratta, Lucia Frittitta
Summary: This study evaluated the efficacy of liraglutide treatment in patients who experienced poor response after bariatric surgery. The results showed that liraglutide was effective in promoting significant weight loss, improving body composition, and reducing the prevalence of metabolic syndrome in these patients.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Paolo Formenti, Silvia Coppola, Laura Massironi, Giacomo Annibali, Francesco Mazza, Lisa Gilardi, Tommaso Pozzi, Davide Chiumello
Summary: This study aimed to evaluate the presence of diastolic dysfunction in mechanically ventilated ARDS patients and found those with diastolic dysfunction had higher lung edema and worse outcomes, but the impact on oxygenation and respiratory mechanics was not significant.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Glenn D. Crater, Karine Lalonde, Francois Ravenelle, Michael Harvey, Jean-Pierre Despres
Summary: This study evaluated the clinical safety and pharmacodynamic profile of a novel CB1R inverse agonist, INV-202, in adults with features of metabolic syndrome. The results showed that INV-202 was well tolerated and produced significant weight loss, reductions in waist circumference and BMI. These findings suggest that INV-202 has potential in improving metabolic syndrome.
DIABETES OBESITY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Silke Zimmermann, Maria Beatriz Walter Costa, Akash Mathew, Shruthi Krishnan, Jochen G. Schneider, Kirsten Roomp, Berend Isermann, Ronald Biemann
Summary: Bone-derived osteocalcin has been suggested as a metabolic regulator and its increased serum levels following lifestyle-induced weight loss in individuals with metabolic syndrome were primarily associated with reduced inflammation rather than improvements in insulin sensitivity, fat mass, or bone mineral density.
Article
Medicine, General & Internal
Sangeetha Shyam, Jesus Francisco Garcia-Gavilan, Indira Paz-Graniel, Jose J. Gaforio, Miguel angel Martinez-Gonzalez, Dolores Corella, J. Alfredo Martinez, angel M. Alonso-Gomez, Julia Waernberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Pilar Matia-Martin, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia-Regata, Estefania Toledo, Eva M. Asensio, Olga Castaner, Antonio Garcia-Rios, Laura Torres-Collado, Enrique Gomez-Gracia, M. Angeles Zulet, Nuria Goni Ruiz, Rosa Casas, Naomi Cano-Ibanez, Lucas Tojal-Sierra, A. M. Gomez-Perez, Jose V. Sorli, Sergio Cinza-Sanjurjo, Sandra Martin-Pelaez, Patricia J. Pena-Orihuela, Alejandro Oncina-Canovas, Rafael Perez-Araluce, Maria Dolores Zomeno, Alice Chaplin, Miguel Delgado-Rodriguez, Nancy Babio, Montserrat Fito, Jordi Salas-Salvado
Summary: Older adults with overweight/obesity are at increased risk of COVID-19, with higher baseline body weight, BMI, waist circumference, and waist-to-height ratio associated with higher risk. Every unit increase in body weight and BMI during follow-up was also linked to increased COVID-19 risk. In this group, significant weight loss may help protect against COVID-19.
Article
Biochemistry & Molecular Biology
Cristina Tudoran, Mariana Tudoran, Talida Georgiana Cut, Voichita Elena Lazureanu, Felix Bende, Renata Fofiu, Alexandra Enache, Silvius Alexandru Pescariu, Dorin Novacescu
Summary: This study analyzed the evolution of diastolic dysfunction (DD) in individuals with post-COVID-19 syndrome. The results showed that DD was commonly diagnosed in patients with obesity and metabolic syndrome (MS), but there was also a significant prevalence in non-obese individuals. The severity of DD gradually decreased, especially in patients without MS.
Article
Cardiac & Cardiovascular Systems
Angel M. Alonso Gomez, Lucas Tojal Sierra, Noris Mora Mora, Estefania Toledo, Alvaro Alonso, Maria Garrido Uriarte, Carolina Sorto Sanchez, Maria P. Portillo, Luis Lopez Rodriguez, Elena Escribano Arellano, Helmut Schroder, Jordi Salas-Salvado
Summary: This study confirms the low prevalence of diastolic dysfunction in overweight/obese patients with metabolic syndrome. Adding the left atrial strain criterion to the current recommendations significantly reduces the number of indeterminate patients by reclassifying them as normal.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vincent Careau, Lewis G. Halsey, Herman Pontzer, Philip N. Ainslie, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V. C. Bouten, Maciej S. Buchowski, Nancy F. Butte, Stefan G. J. A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Richard Cooper, Lara R. Dugas, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle Lambert, William R. Leonard, Nader Lessan, Corby K. Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Theresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietilainen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, John J. Reilly, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjodin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A. Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia U. Loechl, Amy H. Luke, Jennifer Rood, Hiroyuki Sagayama, Dale A. Schoeller, William W. Wong, Yosuke Yamada, John R. Speakman
Summary: Understanding the impacts of activity on energy balance is crucial, as increasing activity levels may lead to diminishing returns in energy expenditure. Only a portion of the extra calories burned from additional activity are actually burned that day, with the rest being compensated for by reduced basal energy expenditure. The degree of energy compensation varies among individuals based on their body composition, which may influence the accumulation of body fat and the difficulty of losing weight.
Article
Cardiac & Cardiovascular Systems
Rahele A. Farahani, Shasha Yu, Christopher M. Ferguson, Xiang-Yang Zhu, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, Sandra M. Herrmann, Alejandro R. Chade, Amir Lerman, Lilach O. Lerman, Alfonso Eirin
Summary: The study showed that PTRA treatment improved myocardial mitochondrial damage, enhanced microvascular maturity, reduced oxidative stress and fibrosis, and mitigated left ventricular remodeling and diastolic dysfunction in pigs with MetS and RVH, indicating the therapeutic potential of PTRA in these conditions.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jami L. Josefson, Denise M. Scholtens, Alan Kuang, Patrick M. Catalano, Lynn P. Lowe, Alan R. Dyer, Lucia C. Petito, William L. Lowe, Boyd E. Metzger
Summary: The study revealed that newborn adiposity is correlated with childhood adiposity and partially mediates the effects of maternal glucose and BMI during pregnancy on childhood adiposity.
Article
Multidisciplinary Sciences
Gertrude Ecklu-Mensah, Candice Choo-Kang, Maria Gjerstad Maseng, Sonya Donato, Pascal Bovet, Bharathi Viswanathan, Kweku Bedu-Addo, Jacob Plange-Rhule, Prince Oti Boateng, Terrence E. Forrester, Marie Williams, Estelle V. Lambert, Dale Rae, Nandipha Sinyanya, Amy Luke, Brian T. Layden, Stephen O'Keefe, Jack A. Gilbert, Lara R. Dugas
Summary: The relationship between microbiota, short chain fatty acids (SCFAs), and obesity remains unclear. This study found that obesity is associated with a reduction in SCFA concentration, microbial diversity, and SCFA synthesizing bacteria, with country of origin being the strongest explanatory factor. The global microbiota can accurately predict diabetes, glucose state, hypertension, obesity, and sex, but predictive accuracy is only maintained for sex at the country level. Diabetes, glucose, and hypertension are only predictive in certain low-income countries.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Birgit Braun, Joachim Demling, Thomas H. Loew
Article
Anesthesiology
Winfried Haeuser, Frietjof Bock, Michael Hueppe, Monika Nothacker, Heike Norda, Lukas Radbruch, Marcus Schiltenwolf, Matthias Schuler, Thomas Toelle, Annika Viniol, Frank Petzke
Article
Oncology
Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jurgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach, Claas Lahmann, Ilinca Popp
Article
Psychology, Clinical
Almut Zeeck, Sabine Schlegel, Friederike Jagau, Claas Lahmann, Armin Hartmann
JOURNAL OF EATING DISORDERS
(2020)
Article
Psychiatry
Christine Allwang, Birgitt Marten-Mittag, Andreas Dinkel, Daniel Mauss, Claas Lahmann
FRONTIERS IN PSYCHIATRY
(2020)
Article
Endocrinology & Metabolism
Sabine J. M. Sag, Christina Strack, Judith Zeller, Margareta Mohr, Thomas Loew, Claas Lahmann, Lars S. Maier, Marcus Fischer, Andrea Baessler
Summary: This study investigated whether long-term successful weight reduction can reverse endothelial activation in individuals with obesity. The results showed that successful weight reduction led to greater improvements in inflammation and endothelial adhesion markers compared to individuals with obesity who did not achieve significant weight loss.
OBESITY RESEARCH & CLINICAL PRACTICE
(2021)
Article
Psychiatry
Sophia von Muenchhausen, Matthias Braeunig, Ruth Pfeifer, Anja S. Goeritz, Joachim Bauer, Claas Lahmann, Alexander Wuensch
Summary: This study investigates the complex relationship between teacher self-efficacy and mental health, as well as their changes during an intervention. It found a significant, moderate correlation between teacher self-efficacy and mental health, and that increasing self-efficacy can lead to improvements in life satisfaction and the ability to distance oneself from others.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Karina Limburg, Katharina Radziej, Heribert Sattel, Peter Henningsen, Marianne Dieterich, Thomas Probst, Rachel Dale, Claas Lahmann
Summary: The study conducted a randomized controlled superiority trial comparing an integrative psychotherapeutic group treatment (IPGT) to self-help groups moderated by a clinical psychologist (SHG) for reducing vertigo/dizziness-related impairment, depression, anxiety, and somatization. The results showed that both IPGT and SHG were effective in reducing vertigo-related impairment and improving depression symptoms, with no significant differences between the two groups. IPGT was also better accepted by patients compared to SHG, and had lower attrition rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Bodo C. Melnik, Wolfgang Stremmel, Ralf Weiskirchen, Swen Malte John, Gerd Schmitz
Summary: Human milk contains multiple biologically active components that support infant growth, health, and development. Milk-derived extracellular vesicles (MEVs), specifically milk exosomes (MEX) and their miRNA cargo, play key roles in intestinal maturation, barrier function, and suppression of NF-kappa B signaling. Understanding the molecular biology of milk provides insights into how infants are both breast-fed and breast-programmed.
Article
Psychology, Clinical
Almut Zeeck, Katharina Endorf, Sebastian Euler, Laura Schaefer, Inga Lau, Kristina Floesser, Valeria Geiger, Alexander Ferdinand Meier, Peter Walcher, Claas Lahmann, Armin Hartmann
Summary: The pilot study evaluated the effectiveness of a day hospital program for eating disorders after MBT implementation, showing significant reductions in eating and general pathology. While no advantage was found compared to a historical control group, the program was associated with low drop-out rates and changes targeted by MBT.
EUROPEAN EATING DISORDERS REVIEW
(2021)
Article
Psychology, Clinical
K. Simshaeuser, R. Pohl, P. Behrens, C. Schultz, C. Lahmann, S. Schmidt
Summary: The migraine-specific MBCT program showed a significant reduction in headache frequency and improvement in psychological functioning, but did not result in improvements in headache-related impairment.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2022)
Article
Environmental Sciences
Sarah Susanne Luetke Lanfer, Ruth Pfeifer, Claas Lahmann, Alexander Wuensch
Summary: In order to improve the health of teachers, it is important to assess their mental health using reliable instruments. This study found that the GHQ-12 questionnaire is an appropriate tool for measuring the mental health of teachers, with good reliability and high correlation to other measures. However, the study also revealed that the mental health of the investigated teachers was worse than that of the general population in Germany, highlighting the need for prevention programs to support and promote their mental well-being.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychology, Clinical
Elke Humer, Heribert Sattel, Harald Guendel, Peter Henningsen, Johannes Kruse, Gudrun Schneider, Claas Lahmann, Christoph Pieh, Thomas Probst
Summary: The study found that stress partially mediated the outcome of PIT for MSD patients, while depression and therapeutic alliance did not have a mediating effect. Future research is needed to explore specific psychotherapeutic mechanisms of change that are beneficial in PIT treatment for MSD patients.
PSYCHOTHERAPY RESEARCH
(2021)
Article
Psychology, Clinical
Joost Dekker, Marie Amitami, Anne H. Berman, Helen Brown, Bryan Cleal, Maria Joao Figueiras, Lila J. Finney Rutten, Egil A. Fors, Konstadina Griva, Jing Gu, Chris Keyworth, Maria Kleinstauber, Claas Lahmann, Joseph T. F. Lau, Bernd Leplow, Li Li, Hanna Malmberg Gavelin, Ricarda Mewes, Phoenix K. H. Mo, Barbara Mullan, Frank J. Penedo, Judith Prins, Teresa Rodriguez Rodriguez, Sharon A. Simpson, Adrienne Stauder, Martti T. Tuomisto, Deborah Jones Weiss, Urs M. Nater
Summary: The study used the Delphi method to update the definition and scope of behavioral medicine and propose the main tasks and goals of ISBM. Behavioral medicine was defined as a field of research and practice that builds on collaboration among multiple disciplines concerned with development and application of behavioral and biomedical evidence across the disease continuum. ISBM's main tasks and goals focus on supporting communication and collaboration across disciplines, stimulating research, education, and practice, and supporting individuals and organizations in the field.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Psychology, Clinical
Thomas Probst, Maria Kleinstaeuber, Michael J. Lambert, Karin Tritt, Christoph Pieh, Thomas H. Loew, Reiner W. Dahlbender, Jaime Delgadillo
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2020)