Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Scott Friedberg, David Choi, Thomas Hunold, Natalie K. Choi, Nicole M. Garcia, Emma A. Picker, Nathaniel A. Cohen, Russell D. Cohen, Sushila R. Dalal, Joel Pekow, Atsushi Sakuraba, Noa Krugliak Cleveland, David T. Rubin
Summary: In this study, the authors reported a large real-world experience with the use of upadacitinib in patients with ulcerative colitis and Crohn's disease. They found that upadacitinib was rapidly effective and safe, even in patients who had prior exposure to tofacitinib.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Shahana Prakash, Tomohiro Tanaka, Divya Ashat
Summary: Indeterminate colitis (IC) is a subtype of inflammatory bowel disease (IBD) with features of both Crohn's disease (CD) and ulcerative colitis (UC). This study examines the characteristics of patients hospitalized with IC in the United States (US) and compares them with patients admitted with CD and UC. The study also analyzes trends in cost and length of stay.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
Summary: Maternal smoking during pregnancy has an impact on the risk of Crohn's disease in adult offspring. Personal smoking and genetic risk amplify this effect.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Frank Phillips, Bram Verstockt, Malgorzata Sladek, Nanne de Boer, Konstantinos Katsanos, Konstantinos Karmiris, Ahmad Albshesh, Carl Erikson, Daniel Bergemalm, Tamas Molnar, Pierre Ellul
Summary: There is a correlation between orofacial granulomatosis (OFG) and Crohn's disease (CD), which can occur before, concurrently with, or after CD diagnosis. Perianal and upper gastrointestinal diseases are common associations, with a significant symptom burden in many patients. Remission can be achieved with various immunosuppressive treatments, including several biologics approved for CD.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W. Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ajuja, Nicola Panaccione, Abdel-Azi Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabian Juliao-Banos, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao, Maojuan Li
Summary: This study investigates the hospitalization rates of inflammatory bowel disease (IBD) in different regions of the world and finds that while the rates are stabilizing in developed countries, they are rapidly increasing in newly industrialized countries, leading to a growing burden on global healthcare systems.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Cell Biology
Malgorzata Maraj, Beata Kusnierz-Cabala, Paulina Dumnicka, Katarzyna Gawlik, Dorota Pawlica-Gosiewska, Agnieszka Gala-Bladzinska, Anna Zabek-Adamska, Piotr Ceranowicz, Marek Kuzniewski
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Medicine, General & Internal
Justyna Wajda, Paulina Dumnicka, Mateusz Sporek, Barbara Maziarz, Witold Kolber, Anna Zabek-Adamska, Piotr Ceranowicz, Marek Kuzniewski, Beata Kusnierz-Cabala
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Dawid Maduzia, Piotr Ceranowicz, Jakub Cieszkowski, Krystyna Galazka, Beata Kusnierz-Cabala, Zygmunt Warzecha
Article
Medicine, General & Internal
Karolina Babiuch, Beata Kusnierz-Cabala, Barbara Kesek, Krzysztof Okon, Dagmara Darczuk, Maria Chomyszyn-Gajewska
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Malgorzata Maraj, Paulina Hetwer, Paulina Dumnicka, Piotr Ceranowicz, Malgorzata Mazur-Laskowska, Anna Zabek-Adamska, Zygmunt Warzecha, Beata Kusnierz-Cabala, Marek Kuzniewski
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Justyna Wajda, Paulina Dumnicka, Witold Kolber, Mateusz Sporek, Barbara Maziarz, Piotr Ceranowicz, Marek Kuzniewski, Beata Kusnierz-Cabala
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Medicine, General & Internal
Malgorzata Kielar, Paulina Dumnicka, Agnieszka Gala-Bladzinska, Alina Bedkowska-Prokop, Ewa Ignacak, Barbara Maziarz, Piotr Ceranowicz, Beata Kusnierz-Cabala
Summary: This study aimed to evaluate urinary NGAL as a predictor of changes in kidney transplant function, finding that high urinary NGAL levels may indicate graft dysfunction or urinary tract infections in clinically stable kidney transplant recipients beyond the first year post-transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Kamil Skowron, Magdalena Kurnik-Lucka, Michal Jurczyk, Veronika Aleksandrovych, Paulina Stach, Emil Dadanski, Beata Kusnierz-Cabala, Krzysztof Jasinski, Wladyslaw P. Weglarz, Paulina Mazur, Piotr Podlasz, Krzysztof Wasowicz, Krzysztof Gil
Summary: The study assessed the effects of the activity-based anorexia animal model on daily life in male and female rats of different ages and body weights, revealing significant gonadal and cardiovascular dysfunctions, further validating the reliability of ABA as a research tool.
Article
Biochemistry & Molecular Biology
Beata Kusnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marcin Dembinski, Maria Kapusta, Monika Bociasa-Jasik, Marek Winiarski, Aleksander Garlicki, Tomasz Grodzicki, Michal Kukla
Summary: This preliminary study found that serum galectin-3 levels were significantly increased in COVID-19 patients who developed pneumonia and required intensive care unit (ICU) treatment. Serum galectin-3 showed moderate diagnostic accuracy for diagnosing pneumonia and high diagnostic accuracy for predicting the need for ICU treatment. Further studies are needed to confirm these findings and explore the potential role of galectin-3 in severe COVID-19 cases.
Review
Biochemistry & Molecular Biology
Malgorzata Kielar, Agnieszka Gala-Bladzinska, Paulina Dumnicka, Piotr Ceranowicz, Maria Kapusta, Beata Naumnik, Grzegorz Kubiak, Marek Kuzniewski, Beata Kusnierz-Cabala
Summary: Kidney transplantation is widely accepted as the best renal replacement therapy for patients with end-stage renal disease, but issues like rejection, recurrent kidney disease, or drug toxicity can lead to graft function deterioration. Complement components play a critical role in kidney allograft impairment, and inhibiting them has shown promise in improving graft survival. Understanding the involvement of complement in transplanted kidney damage is key for developing new therapies.
Article
Medicine, General & Internal
Olga Kaczmarczyk, Agnieszka Dabek-Drobny, Michal Wozniakiewicz, Pawel Pasko, Justyna Dobrowolska-Iwanek, Aneta Wozniakiewicz, Agnieszka Piatek-Guziewicz, Pawel Zagrodzki, Tomasz Mach, Malgorzata Zwolinska-Wcislo
Summary: This study evaluated the profile of organic acids in the stool of CD and UC patients and found new links between medication use and organic acid levels in IBD patients. However, no significant correlations were found between organic acid levels and the frequency of dietary fiber consumption.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Kielar, Paulina Dumnicka, Ewa Ignacak, Alina Bedkowska-Prokop, Agnieszka Gala-Bladzinska, Barbara Maziarz, Piotr Ceranowicz, Beata Kusnierz-Cabala
Summary: The study evaluated serum sCD93 levels in long-term kidney transplant recipients and found an inverse association between sCD93 and renal function, suggesting its potential use in early recognition of graft dysfunction.
Article
Medicine, General & Internal
Paulina Dumnicka, Malgorzata Mazur-Laskowska, Piotr Ceranowicz, Mateusz Sporek, Witold Kolber, Joanna Tisonczyk, Marek Kuzniewski, Barbara Maziarz, Beata Kusnierz-Cabala
Summary: In the early phase of acute pancreatitis, monitoring KeGFR values can help evaluate changes in kidney function and predict disease severity. KeGFR performs well in differentiating varying creatinine levels and diagnosing renal failure, while also independently predicting severe acute pancreatitis regardless of other factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
D. Maduzia, P. Ceranowicz, J. Cieszkowski, A. Chmura, K. Galazka, B. Kusnierz-Cabala, Z. Warzecha
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Correction
Physiology
Zygmunt Warzecha, Pawel Sendur, Piotr Ceranowicz, Marcin Dembinski, Jakub Cieszkowski, Beata Kusnierz-Cabala, Romana Tomaszewska, Artur Dembinski
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)