Article
Endocrinology & Metabolism
Bingyan Cao, Meijuan Liu, Qipeng Luo, Qiao Wang, Min Liu, Xuejun Liang, Di Wu, Wenjing Li, Chang Su, Jiajia Chen, Chunxiu Gong
Summary: This study investigated the associations between serum bone turnover marker (BTM) levels and body mass index (BMI) in Chinese children and adolescents, and found that the influence of BMI, age, and pubertal stage on BTMs varied by gender.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bahareh Nazemi Salman, Shayan Darvish, Ancuta Goriuc, Saeideh Mazloomzadeh, Maryam Hossein Poor Tehrani, Ionut Luchian
Summary: Salivary markers of oxidative stress are associated with clinical disease indices such as gingival bleeding and dental caries. The total antioxidant capacity (TAC) increased in patients with more gingival bleeding and decreased in adolescents with caries. Antioxidants could potentially be used as a preventive and therapeutic measure against oral diseases in the future.
Article
Pediatrics
Wen Xing, Lin Liang, Na Dong, Liang Chen, Zhizhong Liu
Summary: This study investigated the association between bone metabolism indicators and children with cerebral palsy (CP). The study found significant differences in bone turnover markers and bone metabolism indicators between the CP group and the healthy control group. These indicators changed with age, but did not correlate with disease severity.
FRONTIERS IN PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Michael Schonemann Rand, Sarah Seberg Diemar, Line Tang Mollehave, Malene Heidemann, Betina Heinsbaek Thuesen, Jorgen Holm Petersen, Jesper Johannesen, Anders J. Schou, Niels Wedderkopp, Christian Molgaard, Niklas Rye Jorgensen
Summary: The objective of this study was to establish sex- and age-specific reference curves for bone turnover markers (BTM) and to examine their association with change in total body less head bone mineral density (TBLH BMD) in children and adolescents. The results showed that BTM levels peak at the age of 11 to 12 years in girls and 13 to 14 years in boys, corresponding to the age at peak height velocity. BTM Z-scores were positively associated with change in TBLH BMD Z-score.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Sobhy Yakout, Shaun Sabico, Kaiser Wani, Syed Danish Hussain, Naji Aljohani, Suma Uday, Wolfgang Hoegler
Summary: Nutrition-acquired osteomalacia is prevalent in Arab adolescents, with a higher prevalence in girls compared to boys, which is likely associated with Arab traditional clothing and diet.
Article
Environmental Sciences
Tianyu Zhao, Iana Markevych, Marie Standl, Zhonglin Lyu, Tamara Schikowski, Dietrich Berdel, Sibylle Koletzko, Andrea von Berg, Joachim Heinrich
Summary: This study found that long-term exposure to ambient ozone was associated with decreased concentrations of bone turnover markers in German children. However, unless other studies confirm these results, the detrimental effects of ambient ozone on bone development in children should be interpreted cautiously.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pediatrics
Tanju Celik, Ozlem Sangun, Sule Unal, Ali Balci, Sedat Motor
Summary: The study suggests that serum OPG concentration can be used as a biochemical marker for screening the development of osteoporosis in patients with beta-thalassemia major.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Carmela de Lamas, Paula Sanchez-Pintos, Maria Jose de Castro, Miguel Saenz de Pipaon, Maria Luz Couce
Summary: This systematic review evaluates the relationship between screen time and bone health in children and teenagers, finding a negative association between total and TV viewing screen time with bone health, while recreational computer use showed no significant impact. The findings suggest that strategies for improving bone health in adolescents should consider the implications of different technological devices on screen time.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Maike Wolters, Manuela Marron, Ronja Foraita, Charalampos Hadjigeorgiou, Stefaan De Henauw, Gabriele Eiben, Fabio Lauria, Iris Iglesia, Luis A. Moreno, Denes Molnar, Toomas Veidebaum, Wolfgang Ahrens, Rajini Nagrani, IDEFICS, I Family Consortia
Summary: This study examined the association between vitamin D levels and cardiometabolic risk markers in children and adolescents, stratified by BMI category. The results showed that low vitamin D concentrations were associated with unfavorable levels of cardiometabolic markers. Therefore, early interventions to improve vitamin D levels may help reduce cardiometabolic risk in children and adolescents.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Heidi J. Kalkwarf, John A. Shepherd, Didier Hans, Elena Gonzalez Rodriguez, Joseph M. Kindler, Joan M. Lappe, Sharon Oberfield, Karen K. Winer, Babette S. Zemel
Summary: This study aimed to develop reference ranges for trabecular bone score (TBS) in youth aged 5 to 20 years and investigate its association with height, body mass index (BMI), and other bone density measures. The findings suggest that TBS Z-scores provide unique information and can be a valuable tool for clinical assessment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Desiree Lopez-Gonzalez, Jonathan C. Wells, Mario Cortina-Borja, Mary Fewtrell, Armando Partida-Gaytan, Patricia Clark
Summary: This study provides reference values for relevant bone health variables for healthy Mexican children and adolescents, aiding in more precise assessment of bone health. The reference data include percentiles and gender-specific values. Additionally, height-relative and Tanner-stage reference values are provided.
Article
Pediatrics
M. Rebecca Heiner-Fokkema, Ineke J. Riphagen, Nicole S. Wiersema, Jelmer J. van Zanden, Jenny E. Kootstra-Ros, Tineke H. Pinxterhuis, H. Louise Hooimeijer, Francjan J. van Spronsen, Anneke C. Muller Kobold, Wilhelmina H. A. de Jong
Summary: This study investigated plasma vitamin B12 markers in 170 children aged 0-18, deriving age-dependent reference intervals. Plasma methylmalonic acid was higher in young children, total cobalamin and holotranscobalamin peaked between 0.5-4 years and decreased by age 10. Plasma holotranscobalamin was correlated with total cobalamin, with their ratio independent of age. Early recognition and monitoring of children with suspected vitamin B12 deficiency may benefit from pediatric reference values for cobalamin markers.
PEDIATRIC RESEARCH
(2021)
Article
Endocrinology & Metabolism
Joel A. Vanderniet, Vivian Szymczuk, Wolfgang Hogler, Signe S. Beck-Nielsen, Suma Uday, Nadia Merchant, Janet L. Crane, Leanne M. Ward, Alison M. Boyce, Craig F. Munns
Summary: Denosumab is an effective treatment for RANKL-mediated disorders in children and adolescents, although it is not curative and may be used in combination with surgical or other medical treatments. Multidisciplinary planning and expert oversight are necessary to manage the risk of mineral abnormalities. More research is needed to determine optimal treatment regimens and minimize risks.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Patrizia Proia, Alessandra Amato, Patrik Drid, Darinka Korovljev, Sonya Vasto, Sara Baldassano
Summary: Diet and physical activity play a crucial role in children's bone health, with adequate nutrients and proper exercise helping to maximize bone mass. Most existing studies are translated from research in adults, leaving unanswered questions about the type of diet and exercise that can positively influence skeletal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Joanna Gajewska, Katarzyna Szamotulska, Witold Klemarczyk, Magdalena Chelchowska, Malgorzata Strucinska, Jadwiga Ambroszkiewicz
Summary: The study aimed to analyze the changes in neuroendocrine peptides regulating appetite, mainly nesfatin-1 and spexin, in children with Prader-Willi syndrome undergoing growth hormone treatment and reduced energy intake. The results showed that nesfatin-1 values were similar in the control group and the PWS subgroup with BMI Z-score < -0.5, while higher in the PWS subgroup with BMI Z-score >= -0.5. Both PWS subgroups had lower spexin values compared to the control group. These differences may contribute to the metabolic disorders observed in Prader-Willi syndrome.
Article
Nutrition & Dietetics
Jadwiga Ambroszkiewicz, Joanna Gajewska, Joanna Mazur, Katarzyna Kusmierska, Witold Klemarczyk, Grazyna Rowicka, Malgorzata Strucinska, Magdalena Chelchowska
Summary: Scientific studies show that most vegetarians meet the total protein requirements, but little is known about their amino acid intakes. This study aimed to assess the dietary intake and serum amino acid levels of prepubertal children on vegetarian and traditional diets, and their relationship to bone metabolism markers. Results indicate that vegetarian children have significantly lower protein and amino acid intake, as well as lower serum levels of certain amino acids, compared to omnivores.
Article
Biochemistry & Molecular Biology
Joanna Gajewska, Jadwiga Ambroszkiewicz, Katarzyna Szamotulska, Grazyna Rowicka, Malgorzata Strucinska, Witold Klemarczyk, Magdalena Chelchowska
Summary: This study found that non-obese children with Prader-Willi syndrome (PWS) have oxidative stress, with higher concentrations of total oxidant capacity (TOC) and oxidative stress index (OSI) compared to healthy children. The study also found positive associations between TOC values and the percentage of energy requirement, BMI Z-score, fat mass, and levels of leptin, nesfatin-1, and hepcidin in PWS patients. Adipokines such as leptin, nesfatin-1, or hepcidin may play a role in the prooxidant state in non-obese children with PWS.
Article
Biochemistry & Molecular Biology
Grazyna Rowicka, Witold Klemarczyk, Jadwiga Ambroszkiewicz, Malgorzata Strucinska, Ewa Kawiak-Jawor, Halina Weker, Magdalena Chelchowska
Summary: The study found that children on a vegetarian diet had lower oxidative stress index and higher total antioxidant capacity compared to omnivores, suggesting that vegetarianism helps maintain the oxidant-antioxidant balance in children.
Article
Biochemistry & Molecular Biology
Magdalena Chelchowska, Justyna Jurczewska, Joanna Gajewska, Joanna Mazur, Dorota Szostak-Wegierek, Ewa Rudnicka, Jadwiga Ambroszkiewicz
Summary: Metabolic disorders in women with PCOS may lead to increased oxidative stress and reproductive failure. This study evaluated the levels of antioxidant parameters and proteins involved in cellular redox in the serum of PCOS patients. It found that abdominal obesity, as indicated by the VAT/SAT ratio and WHR, was associated with higher concentrations of oxidative markers and lower cellular redox index. The study suggests that oxidative stress associated with abdominal obesity may disrupt cellular processes and activate antioxidant enzymes. Further research is needed to confirm these associations in a larger group of PCOS patients.
Article
Nutrition & Dietetics
Justyna Jurczewska, Joanna Ostrowska, Magdalena Chelchowska, Mariusz Panczyk, Ewa Rudnicka, Marek Kucharski, Roman Smolarczyk, Dorota Szostak-Wegierek
Summary: Abdominal obesity increases the odds of insulin resistance (IR) in women with polycystic ovary syndrome (PCOS). Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), VAT/SAT ratio, and waist-to-hip ratio (WHR) are indicators of abdominal adiposity that are associated with IR. Adhering to a recommended diet for IR and engaging in vigorous physical activity can help reduce central fat accumulation and improve the management of abdominal obesity in PCOS women.