Article
Polymer Science
Manuel Nunez-Martinez, Sandra Arias, Julian Bergueiro, Emilio Quinoa, Ricardo Riguera, Felix Freire
Summary: A novel method was used to prepare PPA-Au nanocomposites by avoiding interactions between the polymer and gold ions, and using strong thiol-Au connections to restrict conformational changes in the polymer. This approach successfully achieved the ordered alignment and stability of nanoparticles along the polymer chain.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Qiaomu Yao, Andrey V. V. Berenov, Ryan Bower, Bin Zou, Xiaofei Xiao, Neil M. M. Alford, Rupert F. M. Oulton, Peter K. K. Petrov
Summary: Gold nanoparticle (AuNP) decoration is a commonly used method to enhance optical responses. This study found that the growth mechanisms of AuNPs vary depending on the substrate, which has a significant impact on the sample's properties.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chenyu Jiang, Fanyu Meng, Dongsheng Mao, Yuguo Tang, Peng Miao
Summary: A tetrahedral DNA nanostructure was assembled in this study, conjugated with gold nanoparticles and carbon nanodots for dual fluorescence channel analysis of telomerase activity and miRNA. The addition of an iRGD peptide sequence allowed for easy transfer of the nanoconjugates inside living cells for in situ imaging. The materials showed excellent analytical performance, anti-jamming capabilities, and high biocompatibility. This biosystem has potential for quantitative analysis of dual biomarkers and as a versatile platform for in situ detection of various targets for early disease diagnosis.
Article
Chemistry, Multidisciplinary
Chuxuan Ling, Zhicheng Jin, Justin Yeung, Elany Barbosa da Silva, Yu-Ci Chang, Tengyu He, Wonjun Yim, Anthony J. O'Donoghue, Jesse V. Jokerst
Summary: A colorimetric method for rapid detection of norovirus based on valence-driven peptide-AuNP interactions is reported. The method utilizes a peptide sequence and a specific enzyme reaction to determine the presence of norovirus in the sample, and shows good detection performance.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Natalie S. Potter, Alan McLean, Evan C. Bornowski, Thomas Hopkins, Jingyi Luo, John P. Wolfe, Wei Qian, Raoul Kopelman
Summary: The synthesis of two metaiodobenzylguanidine (MIBG) derivatives, MIBG-3-MPAM and BG-3-MPAM, is reported. These molecules can be conjugated with nanocarriers and enhance the uptake of gold nanoparticles in cells. The iodine atom plays an important role in enhancing the uptake efficiency.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Analytical
Maria Slyusarenko, Sergey Shalaev, Alina Valitova, Lidia Zabegina, Nadezhda Nikiforova, Inga Nazarova, Polina Rudakovskaya, Maxim Vorobiev, Alexey Lezov, Larisa Filatova, Natalia Yevlampieva, Dmitry Gorin, Pavel Krzhivitsky, Anastasia Malek
Summary: A nanozyme-based technique using AuNPs aptasensors was developed to quantify plasma CD30 + SEVs, allowing for monitoring of classical Hodgkin lymphoma (cHL) activity. The method showed good performance in differentiating healthy donors and cHL patients, and a significant decrease in CD30 + SEVs was observed in the plasma of cHL patients after two cycles of chemotherapy.
Article
Chemistry, Multidisciplinary
Yu Yang, Daoling Peng, Zhenglong Gu, Lei Jiang, Bo Song
Summary: Living systems can efficiently use energy and modulate biological functions through biophotons. This study proposed an optimized system to detect mid-infrared biophotons generated from the hydrolysis of dNTPs, energy-storing molecules similar to ATP. The findings reveal the release of 33- and 84-THz photons during dNTP hydrolysis, which can drive DNA replication.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Editorial Material
Chemistry, Multidisciplinary
Yu Yang, Daoling Peng, Zhenglong Gu, Lei Jiang, Bo Song
Summary: This study proposes an optimized system to detect mid-infrared (MIR) biophotons generated during the hydrolysis of deoxynucleotide triphosphates (dNTPs), which are energy-storing molecules similar to ATP. The system utilizes quantitative polymerase chain reaction (qPCR) modulated by gold nanoparticles (AuNPs) concentration to detect MIR photons. The findings show that 33- and 84-THz photons are released during dNTP hydrolysis, which can drive DNA replication. This research provides a novel chain-reaction-based method for detecting MIR photons in solution and sheds light on the highly efficient energy utilization in biology.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Rosa M. Giraldez-Perez, Elia M. Grueso, Raquel Jimenez-Aguayo, Alfonso Carbonero, Marina Gonzalez-Bravo, Edyta Kuliszewska, Rafael Prado-Gotor
Summary: This study prepared new nanosystems for effective antibiotic delivery, exhibiting good antibacterial properties and internalization capacity in bacteria, making them suitable for medical applications.
Article
Food Science & Technology
Vickie Modica, Robert Glavits, Timothy S. Murbach, John R. Endres, Gabor Hirka, Adel Vertesi, Erzsebet Beres, Ilona Pasics Szakonyine
Summary: This study investigates the safety of gold nanocrystals (AuNC) in terms of genotoxicity and long-term oral toxicity, and finds that AuNC is not mutagenic, clastogenic, or genotoxic, and shows no toxicity in repeated-dose oral toxicity study.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Xiangyu Song, Huhu Wang, Xinglian Xu
Summary: In this study, a novel biosensing strategy for bacterial sensing based on modified gold nanoparticles (AuNPs) combined with amikacin as the molecular recognition element is proposed. The biosensor shows a good linear correlation with bacterial concentration and can detect bacteria within a short period of time without the need for expensive reagents or complex instruments.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Priscilla Choo, Tingting Liu, Teri W. Odom
Summary: Research has shown that the shape of nanoparticles has an unclear influence on targeted drug delivery to cells. In this study, it was found that the core shape of nanoconstructs affects the dynamics of targeting ligand-receptor interactions on cancer cell membranes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Yonghong Zha, Yansong Li, Pan Hu, Shiying Lu, Honglin Ren, Zengshan Liu, Hualin Yang, Yu Zhou
Summary: This study introduces a double-functionalized gold nanoparticle probe for immunoassay analysis of pesticide residues with high sensitivity and low cost.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Guangpei Qi, Haixia Zou, Xiaohong Peng, Shiliang He, Qiqi Zhang, Wei Ye, Yizhou Jiang, Wentao Wang, Guangli Ren, Xiangmeng Qu
Summary: Metabolic footprinting is a convenient and non-invasive cell metabolomics strategy used to monitor the entire extracellular metabolic process. However, its universality is limited due to the need for pre-treatment of cell medium and specialized equipment. In this study, we developed a fluorescently labeled single-stranded DNA-AuNP encoder that can detect extracellular metabolites, allowing for metabolic response profiling and the identification of cell heterogeneity in tumor cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Hamed Nosrati, Farzad Seidi, Ali Hosseinmirzaei, Navid Mousazadeh, Ali Mohammadi, Mohammadreza Ghaffarlou, Hossein Danafar, Joao Conde, Ali Sharafi
Summary: Utilizing all-in-one nanoparticles for synchronous chemoradiotherapy significantly enhances cancer therapy efficacy, as demonstrated by studies on cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves radiation sensitivity in 4T1 mammary carcinoma and completely eradicates breast cancer.
ADVANCED HEALTHCARE MATERIALS
(2022)