Review
Peripheral Vascular Disease
Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Summary: Women with a history of hypertensive disorders of pregnancy have higher rates of long-term cardiovascular events, and the American Heart Association calls for early identification and risk reduction by physicians. This review discusses the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Veronica Giorgione, Asma Khalil, Jamie O'Driscoll, Basky Thilaganathan
Summary: This study assessed the effectiveness of peripartum screening in predicting CHT after HDP and found that a prediction model combining clinical and echocardiographic features showed excellent accuracy in identifying women at risk of persistent hypertension after HDP.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Kathrin Hassdenteufel, Mitho Muller, Raphael Gutsfeld, Maren Goetz, Armin Bauer, Markus Wallwiener, Sara Y. Brucker, Stefanie Joos, Miriam Giovanna Colombo, Sabine Hawighorst-Knapstein, Ariane Chaudhuri, Gudula Kirtschig, Frauke Saalmann, Stephanie Wallwiener
Summary: Preeclampsia increases the risk of developing chronic hypertension and cardiovascular disease in women, especially those with recurrent preeclampsia. Future medical guidelines should take this potential risk into account.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Medicine, General & Internal
Jarawee Sukmanee, Tippawan Liabsuetrakul
Summary: Women with a history of hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular diseases (CVDs) in later life, especially within the first 5 years postpartum. Preeclamptic women have a higher risk of CVDs compared to women with normotensive pregnancies.
Article
Multidisciplinary Sciences
Hong Wa Yung, Xiaohui Zhao, Luke Glover, Charlotte Burrin, Poh-Choo Pang, Carolyn J. P. Jones, Carolyn Gill, Kate Duhig, Matts Olovsson, Lucy C. Chappell, Stuart M. Haslam, Anne Dell, Graham J. Burton, D. Stephen Charnock-Jones
Summary: Placental ER stress in early-onset pre-eclampsia compromises glycosylation and reduces hormone bioactivity, leading to maternal metabolic disorders. ER stress alters the expression of protein glycosylation-related genes and decreases the expression of sialyltransferases. Aberrant glycosylation of placental proteins is also observed in women with pre-eclampsia, providing a mechanistic link between pre-eclampsia and subsequent maternal metabolic disorders.
Article
Obstetrics & Gynecology
Laura J. Slade, Hiten D. Mistry, Jeffrey N. Bone, Milly Wilson, Maya Blackman, Nuhaat Syeda, Peter von Dadelszen, Laura A. Magee
Summary: A relationship between blood pressure thresholds according to the 2017 American College of Cardiology and American Heart Association criteria and adverse pregnancy outcomes was found. The risk of developing preeclampsia varies based on the blood pressure category, such as elevated blood pressure and stage 1 or 2 hypertension. However, no blood pressure measurements can be used to rule out the development of preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Ismini Mpalatsouka, Myria Zachariou, Maria Kyprianidou, Georgia Fakonti, Konstantinos Giannakou
Summary: This study aims to determine the level of awareness regarding long-term health risks among women who experienced preeclampsia during pregnancy in Cyprus and Greece. The findings revealed that more than half of the women with prior preeclampsia were not aware of hypertensive disorders that can occur during pregnancy before their diagnosis, and a very small percentage of participants were aware of the risk of developing cardiovascular diseases.
FRONTIERS IN MEDICINE
(2023)
Review
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely
Summary: Cardiovascular disease is the leading cause of death for women, and adverse pregnancy outcomes such as gestational diabetes and preeclampsia are unique risk factors. However, these risk factors are often overlooked by providers. This mini-review focuses on the relationship between gestational diabetes, preeclampsia, and cardiovascular disease, as well as the mechanisms and management strategies for women with a history of adverse pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Zolt Arany, Denise Hilfiker-Kleiner, S. Ananth Karumanchi
Summary: Cardiovascular complications during pregnancy, such as preeclampsia and peripartum cardiomyopathy, have become a major cause of maternal mortality and have long-term effects on maternal cardiovascular health. However, the causes and mechanisms underlying these complications are not well understood, and treatment options are limited. Preclinical models have played an important role in advancing our understanding of these diseases.
CIRCULATION RESEARCH
(2022)
Review
Obstetrics & Gynecology
Laura J. Slade, Milly Wilson, Hiten D. Mistry, Jeffrey N. Bone, Natalie A. Bello, Maya Blackman, Nuhaat Syeda, Peter von Dadelszen, Laura A. Magee
Summary: There is a relationship between the blood pressure thresholds defined by the 2017 American College of Cardiology and American Heart Association and adverse pregnancy outcomes. Blood pressure thresholds of 140 mm Hg (systolic) and 90 mm Hg (diastolic) from 20 weeks of gestation can effectively identify women at increased risk of adverse pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Nutrition & Dietetics
Kaylee Slater, Rachael Taylor, Karen Mclaughlin, Craig Pennell, Clare Collins, Melinda Hutchesson
Summary: The current practice in primary health care for women with a history of HDP in Australia is unknown. A survey revealed that women with a history of HDP are more likely to receive blood pressure monitoring rather than CVD preventative care for lifestyle or female-specific risk factors. Both GPs and women expressed the need for increasing awareness of women's risk and improving communication between hospitals and primary care.
Review
Cardiac & Cardiovascular Systems
Renee J. Burger, Hannelore Delagrange, Irene G. M. van Valkengoed, Christianne J. M. de Groot, Bert-Jan H. van den Born, Sanne J. Gordijn, Wessel Ganzevoort
Summary: Pregnancy complications, such as hypertensive disorders, can serve as an indicator for increased risk of cardiovascular disease. However, most research on hypertensive disorders of pregnancy focuses on white populations, which limits evidence-based prevention and intervention strategies for diverse ethnic groups and perpetuates health disparities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Eva G. Mulder, Chahinda Ghossein-Doha, Ella Cauffman, Veronica A. Lopes van Balen, Veronique M. M. M. Schiffer, Robert-Jan Alers, Jolien Oben, Luc Smits, Sander M. J. van Kuijk, Marc E. A. Spaanderman
Summary: Tailored circulatory normalization of nonphysiological hemodynamic changes during pregnancy can reduce the risk of recurrent preeclampsia in high-risk populations. This simple and innovative treatment strategy shows no adverse effects on offspring outcomes.