Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Transplantation
Yuko Katayama, Jun Sugama, Tomohisa Suzuki, Yoshimasa Ishimura, Akihiro Kobayashi, Yusuke Moritoh, Masanori Watanabe
Summary: The study found that the enteropeptidase inhibitor SCO-792 had significant therapeutic effects on chronic kidney disease in rats, preventing declines in glomerular filtration rate, albuminuria, and kidney fibrosis. Furthermore, it increased hydrogen sulphide production capacity, suggesting potential for CKD treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Biochemistry & Molecular Biology
Wataru Fujii, Shigeru Shibata
Summary: This article reviews the extensive research conducted over the past 80 years on the regulation and action of the mineralocorticoid receptor (MR). It highlights the role of MR and the steroid hormone aldosterone in integrating responses of tubular cells and maintaining fluid homeostasis, as well as their dysregulation in kidney diseases. Experimental studies have shown the pathological consequences of MR overactivity and the mechanisms of enhanced MR signaling, while clinical studies have demonstrated the renoprotective effects of MR blockade. The article also discusses future areas of investigation, including the use of non-steroidal MR antagonists in non-diabetic kidney disease patients and the search for downstream mediators of renoprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Pijun Yan, Yong Xu, Ying Miao, Xue Bai, Yuru Wu, Qian Tang, Zhihong Zhang, Jiong Yang, Qin Wan
Summary: Limited data on the association between remnant cholesterol (RC) and chronic kidney disease (CKD) in the Chinese general middle-aged and elderly population suggests that higher RC levels are independently associated with an increased risk of prevalent CKD, especially in women, subjects with overweight/obesity, non-prediabetes, hypertension, normal HDL-C, appropriate and high LDL-C, and those without cardiovascular disease events.
ACTA DIABETOLOGICA
(2021)
Article
Transplantation
Jorge E. Rojas-Rivera, Sevcan A. Bakkaloglu, Davide Bolignano, Ionut Nistor, Pantelis A. Sarafidis, Sokratis Stoumpos, Mario Gennaro Cozzolino, Alberto Ortiz, ERA ERBP
Summary: Chronic kidney disease (CKD) is diagnosed based on glomerular filtration rate (GFR) and urinary albumin:creatinine ratio (UACR). High cardiovascular risk is associated with moderate or severe CKD. The management recommendations for lupus nephritis (LN) and cardiovascular risk in rheumatic and musculoskeletal diseases do not consider albuminuria or CKD. The authors propose a change in the conceptual framework to treat LN as a cause of CKD and apply evidence from large CKD trials.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Carla Santos-Araujo, Luis Mendonca, Daniel Seabra Carvalho, Filipa Bernardo, Marisa Pardal, Joao Couceiro, Hugo Martinho, Cristina Gavina, Tiago Taveira-Gomes, Ricardo Jorge Dinis-Oliveira
Summary: This study provides the first real-world based estimation of the prevalence of chronic kidney disease (CKD) in a large, unselected Portuguese population. The overall estimated prevalence of CKD was 9.8% and was higher in females than males. This study may help healthcare providers in formulating policies and strategies focused on preventing CKD and improving cardiovascular outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Environmental Sciences
Jeonghwan Lee, Inae Lee, Jae Yoon Park, Sunmi Kim, Hyunwoong Park, Sun Kyoung Jung, Chulwoo Lee, Jung Pyo Lee, Kyungho Choi
Summary: We investigated the association between major persistent organic pollutants (POPs) exposure and chronic kidney disease (CKD) among the general adult population of Korea. The study found significant associations between certain POPs, such as PCB153 and PCB180, and decreased estimated glomerular filtration rate (eGFR), particularly in females. Associations were also observed between eGFR and hexachlorobenzene (HCB) in male participants. The study highlights the importance of further validation and research in other populations.
Article
Multidisciplinary Sciences
Jae Young Kim, Sung-youn Chun, Hyunsun Lim, Tae Ik Chang
Summary: This study aimed to examine the association between familial aggregation of chronic kidney disease (CKD) and the risk of CKD development and progression to end-stage renal disease (ESRD). The study analyzed data from 881,453 cases with newly diagnosed CKD and matched controls, finding that the presence of affected family members with CKD was associated with a significantly higher risk of CKD development and disease progression. The findings suggest that familial aggregation of CKD is strongly associated with an increased risk of CKD and progression to ESRD.
SCIENTIFIC REPORTS
(2023)
Article
Transplantation
Peter Rossing, Florian M. M. Baeres, George Bakris, Heidrun Bosch-Traberg, Mette Gislum, Stephen C. L. Gough, Thomas Idorn, Jack Lawson, Kenneth W. Mahaffey, Johannes F. E. Mann, Henriette Mersebach, Vlado Perkovic, Katherine Tuttle, Richard Pratley, FLOW Steering Comm, FLOW Trial Investigators
Summary: This study aims to investigate the effects of semaglutide on kidney outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). The participants were found to be mostly at high risk for CKD progression. The study is expected to be completed in late 2024.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
See Cheng Yeo, Hankun Wang, Yee Gary Ang, Chee Kong Lim, Xi Yan Ooi
Summary: Chronic kidney disease is a significant public health problem, and early identification and treatment can slow its progression and prevent complications. This study reviewed the cost-effectiveness of CKD screening strategies in general adult populations worldwide and identified factors that affect cost-effectiveness.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Nutrition & Dietetics
Mengyi Liu, Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chun Zhou, Panpan He, Yuanyuan Zhang, Jing Nie, Min Liang, Fan Fan Hou, Xianhui Qin
Summary: This study suggests that higher folate intake in young adulthood is associated with a lower incidence of chronic kidney disease later in life, and there is a significant L-shaped relationship.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Jingya Niu, Xiaoyun Zhang, Mian Li, Shujing Wu, Ruizhi Zheng, Li Chen, Yanan Huo, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Guijun Qin, Li Yan, Qin Wan, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Zhengnan Gao, Guixia Wang, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Yufang Bi, Guang Ning, Weiqing Wang, Jieli Lu, Yu Xu
Summary: This study aimed to examine the risks of major cardiovascular events, renal outcomes, and all-cause mortality in type 2 diabetes mellitus patients with different diabetic kidney disease subtypes. A total of 36,509 participants with type 2 diabetes were followed up from 2011 to 2016, and the DKD subtypes were categorized based on albuminuria and reduced estimated glomerular filtration rate. The results showed that non-albuminuria DKD accounted for more than half of DKD cases with low eGFR in Chinese diabetes patients, and these patients had a modest increase in the risks of MACEs and mortality.
DIABETES & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Peter Bramlage, Stefanie Lanzinger, Steffen Muehldorfer, Karsten Milek, Anton Gillessen, Roman Veith, Tobias Ohde, Thomas Danne, Reinhard W. Holl, Jochen Seufert
Summary: German registries show that finerenone, a non-steroidal mineralocorticoid receptor antagonist, reduces the risk of cardiovascular and renal events in patients with type 2 diabetes mellitus and chronic kidney disease. However, the randomized clinical trials did not include all patient subgroups, leading to undertreatment for some patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Urology & Nephrology
Michael J. Blackowicz, Luke Falzon, Werner Beck, Ha Tran, Daniel E. Weiner
Summary: This study evaluates the association between Theranova dialyzer and conventional high-flux dialyzer in terms of hospitalization rates and healthcare costs. The results demonstrate that Theranova is associated with lower hospitalization rates and costs.
HEMODIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Daniel E. Weiner, Christine K. Liu, Shiyuan Miao, Roger Fielding, Leslie I. Katzel, Jamie Giffuni, Andrew Well, Stephen L. Seliger
Summary: The safety and efficacy of long-term exercise training in older adults with advanced CKD and comorbidity is uncertain. This study aimed to evaluate the effects of exercise training on cardiorespiratory fitness and submaximal gait in older adults with CKD. The results showed that exercise training improved cardiorespiratory fitness and walking ability, but the effects diminished after 12 months.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Editorial Material
Urology & Nephrology
Stephen Seliger, Daniel E. Weiner
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Lesley A. Inker, Morgan E. Grams, Hrefna Guomundsdottir, Phil McEwan, Robert Friedman, Aliza Thompson, Daniel E. Weiner, Kerry Willis, Hiddo J. L. Heerspink
Summary: A scientific workshop sponsored by the National Kidney Foundation and the US Food and Drug Administration (FDA) was held to discuss the value of treating early chronic kidney disease (CKD) and the challenges in conducting trials for early CKD. The attendees reached a consensus on the importance of preventing and treating early CKD progression, using surrogate end points to establish efficacy, and conducting comprehensive cost analyses and safety data collection.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Mark J. Sarnak, Bourne L. Auguste, Edwina Brown, Alexander R. Chang, Glenn M. Chertow, Mary Hannan, Charles A. Herzog, Annie-Claire Nadeau-Fredette, Wai Hong Wilson Tang, Angela Yee-Moon Wang, Daniel E. Weiner, Christopher T. Chan
Summary: Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage kidney disease. The current therapy of thrice-weekly in-center hemodialysis has poor outcomes, while emerging evidence suggests that home dialysis may improve cardiovascular risk factors and outcomes. Incorporating interdisciplinary care models to increase the use of home dialysis therapies can contribute to improving outcomes for patients with kidney failure and cardiovascular disease.
Article
Urology & Nephrology
Thalia Porteny, Kristina M. Gonzales, Kate E. Aufort, Sarah Levine, John B. Wong, Tamara Isakova, Dena E. Rifkin, Elisa J. Gordon, Ana Rossi, Gary Di Perna, Susan Koch-Weser, Daniel E. Weiner, Keren Ladin, Stakeholder Advisory Board
Summary: This study analyzed the impact of the COVID-19 pandemic on shared decision making for older patients with CKD. The discussions between clinicians and patients still have room for improvement in this pandemic context, but patients remain satisfied with their treatment choices.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Editorial Material
Urology & Nephrology
Wendy McCallum, Daniel E. Weiner
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Mallika L. Mendu, Scott D. Bieber, Suzanne G. Watnick, Daniel E. Weiner
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
M. Kyla Shea, Jifan Wang, Kathryn Barger, Daniel E. Weiner, Sarah L. Booth, Stephen L. Seliger, Amanda H. Anderson, Rajat Deo, Harold Feldman, Alan S. Go, Jiang He, Ana C. Ricardo, Manjula Kurella Tamura
Summary: This study found an association between vitamin K status and cognitive performance in individuals with chronic kidney disease. Participants with lower levels of plasma (dp)ucMGP, indicating higher vitamin K status, had better cognitive performance. Plasma phylloquinone levels were not significantly associated with cognitive performance. These findings suggest that vitamin K may play an important role in cognitive function in individuals with chronic kidney disease.
CURRENT DEVELOPMENTS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Kimberly R. Dong, Curt G. Beckwith, Anna Grossman, Daniel E. Weiner, Alice H. Lichtenstein
Summary: This study investigated the feasibility of using the probation office setting to screen and assess cardiometabolic risk factors in adults. The findings suggest that it is possible to identify high-risk individuals during routine probation office visits, and referral for treatment can be provided to improve long-term health outcomes.
JOURNAL OF CORRECTIONAL HEALTH CARE
(2022)
Article
Urology & Nephrology
Harold J. Manley, Nien Chen Li, Gideon N. Aweh, Caroline M. Hsu, Daniel E. Weiner, Dana Miskulin, Antonia M. Harford, Doug Johnson, Eduardo Lacson
Summary: The effectiveness of SARS-CoV-2 vaccines and the immunogenicity threshold for protection against COVID-19-related hospitalization or death in the dialysis population are uncertain. This retrospective observational study found that SARS-CoV-2 vaccination in maintenance dialysis patients was associated with a lower risk of COVID-19 diagnosis and related hospitalization or death. Among vaccinated patients, those with lower levels of anti-spike IgG antibodies had higher rates of infection and worse COVID-19-related outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Medicine, General & Internal
Keren Ladin, Hocine Tighiouart, Olivia Bronzi, Susan Koch-Weser, John B. Wong, Sarah Levine, Arushi Agarwal, Lucy Ren, Jack Degnan, Lexi N. Sewall, Brianna Kuramitsu, Patrick Fox, Elisa J. Gordon, Tamara Isakova, Dena Rifkin, Ana Rossi, Daniel E. Weiner
Summary: This study compared the impact of a decision aid for kidney replacement therapy with usual care on decisional quality in older patients with advanced chronic kidney disease. The results showed that the decision aid improved decision quality, increased treatment knowledge, and reduced uncertainty while clarifying treatment preferences.
ANNALS OF INTERNAL MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Allison C. Reaves, Daniel E. Weiner, Caroline M. Hsu
Article
Urology & Nephrology
Daniel E. Weiner, Marc G. Vervloet, Sebastian Walpen, Thilo Schaufler, Catherine Munera, Frederique Menzaghi, Warren Wen, Sarbani Bhaduri, Michael J. Germain
Summary: Difelikefalin is well tolerated and can effectively reduce itch intensity, improve itch-related quality of life, and enhance sleep quality in patients receiving hemodialysis with moderate-to-severe CKD-aP.
Article
Urology & Nephrology
Lindsay M. M. Miller, Manjula Kurella Tamura, Nicholas M. M. Pajewski, Dena Rifkin, Daniel Weiner, Maria Marquine, Michael G. G. Shlipak, Joachim H. H. Ix
Summary: This study is the first evaluation of the relationship between kidney tubule biomarkers and brain imaging by MRI in patients with CKD, and it found that urine biomarker concentrations were not associated with brain MRI measures.
