Article
Psychiatry
Ebenezer Oloyede, Olubanke Dzahini, Zadro Abolou, Siobhan Gee, Eromona Whiskey, Diksha Malhotra, Masuma Hussain, Ian Osborne, Cecilia Casetta, Philip McGuire, James H. H. MacCabe, David Taylor
Summary: To minimize infection during COVID-19, the clozapine hematalogical monitoring interval was extended. This study aims to investigate the impact of this temporary policy change on clinical and safety outcomes.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Christoff Geldenhuys, Moleen Zunza, Nicki Tiffin, Liezl Koen, Eric H. Decloedt
Summary: This study assessed the incidence of hematological side effects in South African patients on clozapine and found that HIV infection was associated with these side effects, while patients with HSEs had an increased risk of developing tuberculosis. The incidence of clozapine-induced HSEs was lower than previously reported and not significantly different compared with risperidone.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Md Harunur Rashid, Dinesh Babu, Newton Tran, Bela Reiz, Arno G. Siraki
Summary: The atypical antipsychotic drugs, quetiapine and clozapine, can be metabolized by neutrophil myeloperoxidase (MPO), and the metabolism of quetiapine involves MPO chlorination activity. The metabolites of quetiapine and clozapine were characterized using various spectroscopic techniques. Quetiapine metabolites were found to be less reactive than clozapine metabolites.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Psychiatry
Katsunori Toyoda, Takeo Hata, Shigeru Yamauchi, Shinya Kinoshita, Masami Nishihara, Kazuhisa Uchiyama, Ken Inada, Tetsufumi Kanazawa
Summary: The survey examined the usage of clozapine and found an increase in cases in the late group, along with a decrease in dosage and higher continuation rates compared to the early group. Differences were observed between the early and late groups in terms of granulocytopenia and agranulocytosis.
PSYCHIATRY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Basile Chretien, Perrine Brazo, Angelique Da Silva, Marion Sassier, Charles Dolladille, Veronique Lelong-Boulouard, Joachim Alexandre, Sophie Fedrizzi
Summary: The study found a significant safety signal between clozapine use and infections, with respiratory and gastrointestinal infections being the most commonly reported. Agranulocytosis demonstrated a stronger association with clozapine-associated reports of infections compared to neutropenia. No evidence of dose-dependency was observed, but significant drug-drug interactions were found with several CYP inhibitors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychiatry
David Taylor, Kalliopi Vallianatou, Eromona Whiskey, Olubanke Dzahini, James MacCabe
Summary: The occurrence of agranulocytosis during clozapine treatment varies in severity, with some episodes being life-threatening while others are not. Monitoring schemes should focus on identifying true life-threatening agranulocytosis induced by clozapine.
Review
Cell Biology
Ann-Kathrin Lederer, Fabian Bartsch, Markus Moehler, Peter Gassmann, Hauke Lang
Summary: Leukocytes play a crucial role in the immune system and cell-cell interaction in the human body. Diseases and chemotherapy can lead to leukocyte deficiency, particularly neutropenia. Neutropenia increases the risk of infection and may cause healing disorders. Neutropenic patients requiring emergency surgery have a higher mortality risk compared to non-neutropenic patients. However, there is no clear tendency for a higher mortality risk in neutropenic patients undergoing elective surgery. Further research is needed to evaluate the risk of postoperative complications in neutropenic patients and the role of neutrophilic function in morbidity and mortality.
Article
Psychology, Clinical
Basile Chretien, Veronique Lelong-Boulouard, Sylvain Chantepie, Marion Sassier, Mickael Bertho, Perrine Brazo, Xavier Humbert, Joachim Alexandre, Sophie Fedrizzi, Charles Dolladille
Summary: The study found a significant association between clozapine and malignant lymphoma and leukemia, with patients in the clozapine treatment group being significantly younger for these hematologic malignancies. There was also a dose-dependent relationship between the dose of clozapine and the risk of developing these malignancies.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Silvia Moga, Andreea Teodorescu, Petru Ifteni, Paula-Simina Petric, Ana-Aliana Miron
Summary: This study aimed to assess the neutrophil count in patients with schizophrenia treated with clozapine and infected with COVID-19. The results showed that the majority of patients did not experience a significant decline in neutrophil count before COVID-19 infection and one month after resolution. However, a small percentage of patients exhibited neutropenia. The study suggests that neutropenia may be a result of the interaction between COVID-19 and clozapine.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Psychiatry
S. A. Handley, S. Every-Palmer, A. Ismail, R. J. Flanagan
Summary: This study investigated the incidence of potentially harmful clozapine-induced gastrointestinal hypomotility (CIGH) in the UK and its impact on patients. The results showed that 33% of patients reported with CIGH died, with the number of deaths increasing over the years. Male patients showed different trends in age and clozapine doses compared to female patients. Surgery was the most frequent outcome for non-fatal CIGH.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Espen Molden
Summary: Clozapine is an effective drug for treating schizophrenia, but its dose-dependent side effects and the risk of agranulocytosis limit its use. Therapeutic drug monitoring can guide individual dosing, but current methods are unable to predict the risk of agranulocytosis.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Clinical Neurology
Laurent Bechard, Olivier Corbeil, Maude Plante, Marc-Andre Thivierge, Charles-Emile Lafreniere, Marc-Andre Roy, Marie-France Demers
Summary: The as-needed use of G-CSF may allow some patients to continue clozapine treatment despite neutropenia, with mild short-lived back pain reported as the only side effect. This approach shows promise for clozapine rechallenge in select patients and may contribute to defining the long-term safety and efficacy of this strategy. More research is needed to identify potential candidates and optimal practice regimens.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Mina Y. George, Esther T. Menze, Ahmed Esmat, Mariane G. Tadros, Ebtehal El-Demerdash
Summary: This study aimed to investigate the potential of naringin as an add-on benefits to alleviate the main side effects of clozapine in ketamine-induced psychosis in rats. Naringin was found to reduce adverse effects induced by clozapine treatment, improve total leukocyte count, lower serum cholesterol and triglycerides levels, prevent weight gain, and reduce serum glucose level. These findings suggest that naringin may have a beneficial role as an add-on therapy to clozapine in the treatment of schizophrenia.
DRUG DEVELOPMENT RESEARCH
(2021)
Letter
Clinical Neurology
H. Hammer, N. Kamber, M. Pistor, L. Diem, C. Friedli, A. Chan, R. Hoepner, A. Salmen
Summary: Using data from FAERS, our analysis identified male sex, younger age, and lower bodyweight as factors associated with OCR-related neutropenia.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Samantha Christine Sernoskie, Alison Jee, Jack Uetrecht
Summary: The risk of idiosyncratic drug-induced agranulocytosis (IDIAG) limits the use of clozapine, but most clozapine patients experience an early inflammatory response, which is likely a necessary step in IDIAG onset. Clozapine activates inflammasomes and myeloperoxidase bioactivates clozapine to generate neoantigens, suggesting a connection between these events and IDIAG.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Gordana Cetkovic, Vanja Seregelj, Andrea Brandolini, Jasna Canadanovic-Brunet, Vesna Tumbas Saponjac, Jelena Vulic, Olja Sovljanski, Dragana Cetojevic-Simin, Dubravka Skrobot, Anamarija Mandic, Lorenzo Estivi, Alyssa Hidalgo
Summary: The aim of this research was to evaluate the quality of durum-wheat pasta enriched with encapsulated carrot waste extracts. The study found that carotenoids were stable during pasta manufacturing, while tocols decreased during both manufacturing and cooking processes, but were still more abundant in the enriched pastas. Additionally, the addition of encapsulated carrot waste extracts significantly improved the nutritional and technological qualities of the pasta.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Psychiatry
Leandro Nicolas Grendas, Luciana Chiapella, Demian Emanuel Rodante, Federico Manuel Daray
Summary: A comparison study between Cox regression models and Random Survival Forest (RSF) was conducted to predict suicidal behavior, and a variant of RSF (RSFElimin) showed better accuracy, sensitivity gAUC, and IBS compared to other methods.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Chemistry, Applied
L. Huaman, S. Huincho, E. Aguirre, G. Rodriguez, A. Brandolini, A. Hidalgo
Summary: This research aimed to evaluate the properties and shelf-life of oils extracted from different Peruvian castor bean ecotypes at two temperatures. The results showed a wide variation in all traits, with low acidity levels, low peroxide values, and absence of p-anisidine. The total tocopherol contents ranged from 798 to 1040 mg/kg, and the methanolic extracts exhibited higher antioxidant capacity compared to the hexane extract. Additionally, the higher extraction temperature led to a longer predicted shelf-life at 25 degrees C, possibly due to enzyme inactivation observed during the Rancimat experiment conducted at 150-170 degrees C.
Article
Food Science & Technology
Vanja Seregelj, Dubravka Skrobot, Jovana Kojic, Lato Pezo, Olja Sovljanski, Vesna Tumbas Saponjac, Jelena Vulic, Alyssa Hidalgo, Andrea Brandolini, Jasna Canadanovic-Brunet, Gordana Cetkovic
Summary: This study investigated the quality of durum wheat pasta enriched with carrot waste encapsulates and determined consumer preferences for this type of product. The results showed that replacement of semolina with the encapsulates led to changes in nutritional quality, as well as color and texture, but these changes were acceptable. The study suggests that carrot waste can be a promising material for producing high-quality pasta.
Article
Economics
Osvaldo Ulises Garay, Gonzalo Guinazu, Yolanda Patricia Adamczuk, Cristina Duboscq
Summary: In the Argentinean health system, the implementation of anticoagulation clinics has been found to be cost-effective, resulting in improved treatment outcomes and reduced adverse events. The addition of point-of-care devices also contributes to cost savings.
PHARMACOECONOMICS-OPEN
(2022)
Article
Biochemistry & Molecular Biology
Gilbert Rodriguez, Elza Aguirre, Any Cordova-Chang, Jenny C. Munoz-Saenz, Mery Baquerizo, Andrea Brandolini, Eudes Villanueva, Alyssa Hidalgo
Summary: The physico-chemical properties and oxidative stability of tarwi and sacha inchi oil blends were studied. All blends had nutritional ratios and tocopherol content suitable for human consumption. The 1:1 tarwi/sacha inchi oil blend exhibited a longer shelf-life and good stability.
Article
Engineering, Chemical
Lorenzo Estivi, Silvia Grassi, Luis Briceno-Berru, Patricia Glorio-Paulet, Felix Camarena, Alyssa Hidalgo, Andrea Brandolini
Summary: This study assessed the free phenolic compounds, antioxidant capacity, and FT-NIR spectra of flours from debittered seeds of different ecotypes of Lupinus mutabilis and other varieties of Lupinus, finding that the debittered flours maintained high levels of free phenolics and antioxidant capacity.
Article
Biochemistry & Molecular Biology
Gjore Nakov, Andrea Brandolini, Lorenzo Estivi, Katia Bertuglia, Nastia Ivanova, Marko Jukic, Daliborka Koceva Komlenic, Jasmina Lukinac, Alyssa Hidalgo
Summary: The addition of tomato pomace improves the nutritional and technological characteristics of cream crackers, increasing ash, fat, protein, dietary fiber, carotenoids, tocols, phenolic compounds, and antioxidant activity while decreasing hardness. Cream crackers with 8% tomato pomace showed the best sensory quality, suggesting the potential for utilizing tomato waste in food products for both nutritional enhancement and waste reduction.
Article
Biochemistry & Molecular Biology
Vanja Seregelj, Lorenzo Estivi, Andrea Brandolini, Gordana Cetkovic, Vesna Tumbas Saponjac, Alyssa Hidalgo
Summary: The encapsulation of carrot waste oil extract improved the antioxidant properties of durum wheat pasta. Freeze-drying was more effective in protecting carotenoids from degradation compared to spray-drying. The activation energies tended to be higher in freeze-dried encapsulates.
Article
Food Science & Technology
Andrea Brandolini, Mara Lucisano, Manuela Mariotti, Lorenzo Estivi, Alyssa Hidalgo
Summary: This research evaluated the composition and technological characteristics of flours and breads of two elite einkorns and a bread wheat grown in four different environments. The results showed that einkorn flour had better composition and technological characteristics compared to bread wheat, resulting in larger and softer breads with a longer shelf life.
Review
Clinical Neurology
Sudan Prasad Neupane, Federico M. Daray, Elizabeth D. Ballard, Hanga Galfalvy, Liat Itzhaky, Aviv Segev, Assaf Shelef, Oren Tene, Mina M. Rizk, J. John Mann, Gil Zalsman
Summary: This study conducted a meta-analysis comparing immune biomarkers between individuals with and without a history of suicidal behavior, finding that suicidal behavior is associated with higher levels of CRP and IL-6, independent of psychiatric disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lorenzo Estivi, Andrea Brandolini, Andrea Gasparini, Alyssa Hidalgo
Summary: Four species of lupin are widely cropped due to their excellent nutritional composition. However, the bitter and toxic alkaloids in lupin seeds need to be eliminated before consumption, affecting its nutritional value. This review summarizes the composition and antioxidant content of lupin, as well as the effects of technological processes and food manufacturing on its nutritional value and antioxidant content.
Article
Chemistry, Applied
Lorenzo Estivi, Gloria J. Pascual Chagman, Juan Edgar Santa Cruz Olivos, Pietro Savasi, Andrea Brandolini, Alyssa Hidalgo
Summary: This study investigated the impact of controlled germination on the color, carotenoids, and tocopherols of Andean lupin seeds. The results showed that germination significantly modified the characteristics examined, with a decrease in luminosity and an increase in carotenoids, particularly lutein. The tocopherol content also changed, with an increase in α-tocopherol and a decrease in γ-tocopherol.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Chemistry, Applied
Andrea Brandolini, Patricia Glorio-Paulet, Lorenzo Estivi, Nicola Locatelli, Javier S. Cordova-Ramos, Alyssa Hidalgo
Summary: This study investigated the effects of debittering, extrusion, and spray-drying on the antioxidants of three Andean lupin ecotypes. The results showed that debittering increased the content of tocopherols and bound flavonoids, while decreasing the content of free phenolics and bound phenolic acids. Extrusion had little effect on tocopherols, slightly increased phenolics, and marginally reduced carotenoids. Spray-drying diminished tocopherols, carotenoids, and phenolics, mainly due to processing conditions.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Psychiatry
Demian E. Rodante, Marcela Kaplan, Ramiro Olivera Fedi, Pablo Gagliesi, Agustina Pascali, Paula S. Jose Quintero, Emilio J. Compte, Ana Perez, Melina Weinstein, Luciana C. Chiapella, Federico M. Daray
Summary: This study evaluated the acceptability and preliminary effectiveness of a mobile-health application called CALMA, which is based on dialectical behavioral therapy skills. The results showed that CALMA had good acceptability as an adjunct therapy for reducing suicidal and non-suicidal self-injury behaviors.
ARCHIVES OF SUICIDE RESEARCH
(2022)
