期刊
ADVANCES IN APPLIED MATHEMATICS
卷 41, 期 3, 页码 335-350出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.aam.2007.11.003
关键词
Discrete dynamical systems; Boolean networks; Regulatory networks; Genetic regulation; Differentiation; Homeostasis; Thomas' rules; Discrete Jacobian matrix; Jacobian conjecture
资金
- French Ministry of Research (ACI IMPbio)
- Agence Nationale de la Recherche [ANR-05-JCJC-0126-01]
- Institut de Mathematiques de Luminy [IML 2005-08]
To each Boolean function f: (0, 1}(n) -> {0, 1}(n) and each x is an element of {0, 1}(n), we associate a signed directed graph G(x). and we show that the existence of a positive circuit in G(x) for some v is a necessary condition for the existence of several fixed points in the dynamics (the sign of a circuit being defined as the product of the signs of its edges), and that the existence of a negative circuit is a necessary condition for the existence of an attractive cycle. These two results are inspired by rules for discrete models of genetic regulatory networks proposed by the biologist R. Thomas. The proof of the first result is modelled after a recent proof of the discrete Jacobian conjecture. (c) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据