Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Oncology
Kevin L. Ma, Cimarron E. Sharon, Gabriella N. Tortorello, Nikhita J. Perry, Luke J. Keele, John N. Lukens, Giorgos C. Karakousis, John T. Miura
Summary: This retrospective cohort study analyzed data from the National Cancer Database from 2012 to 2019. The study found that there was no significant difference in survival benefits between radiation therapy and completion lymph node dissection for regional lymph node micrometastasis in Merkel cell carcinoma (MCC) patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Adrienne B. Shannon, James Sun, Karenia Landa, Kirsten M. Baecher, Christian Wood, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Tsai, Mark B. Faries, Georgia M. Beasley, Vernon Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
Summary: The study revealed that in clinically localized Merkel cell carcinoma, males, patients over 75 years old, and those with lymphovascular invasion are more likely to have false negative SLNB results. Patients with false negative SLNB experienced shorter time to nodal recurrence and significantly worse survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Sean M. Hacking, Kara-Lynne Leonard, Dongling Wu, Mara Banks, Theresa Graves, Lijuan Wang, Evgeny Yakirevich, Yihong Wang
Summary: The use of sentinel lymph node biopsy (SLNB) in patients with microinvasive breast cancer (MIBC) has been debated. This study evaluated clinical and histological features to predict disease free survival (DFS) and factors influencing clinical decision making in MIBC patients. SLNB was found to be associated with mastectomy, high nuclear grade, and negativity for ER and HER-2. However, SLNB did not impact DFS in this study.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Anthony T. Nguyen, Michael Luu, Diana J. Lu, Omid Hamid, Jon Mallen-St Clair, Mark B. Faries, Nima M. Gharavi, Allen S. Ho, Zachary S. Zumsteg
Summary: The number of metastatic lymph nodes is the key factor affecting survival in patients with Merkel cell carcinoma (MCC). A novel nodal classification system was developed, which showed improved concordance compared with the American Joint Committee on Cancer, Eighth Edition.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Oncology
Neal Andruska, Lily Mahapatra, Randall J. Brenneman, Yi Huang, Randal C. Paniello, Sidharth V. Puram, Mena Mansour, Jason T. Rich, Brian C. Baumann, Wade L. Thorstad, Mackenzie D. Daly
Summary: Regional lymph node radiation therapy, including definitive nodal radiotherapy and adjuvant nodal radiotherapy, has been shown to improve regional recurrence-free survival, distant recurrence-free survival, disease-free survival, and disease-specific survival in patients with Merkel cell carcinoma. Adjuvant nodal radiotherapy is particularly beneficial for high-risk subgroups and its benefit increases with higher disease burden. These results support a more liberal use of nodal RT for MCC patients with node-positive disease.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Surgery
YiJun Xia, DongSheng Cao, Jun Zhao, BangZhong Zhu, Juan Xie
Summary: A study of 1822 patients with MCC found that RLN status affects patient prognosis, but is not an independent predictor.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Oncology
Eva Huis In't A. Veld, Thomas Boere, Charlotte L. Zuur, Michel W. Wouters, Alexander C. J. van Akkooi, John B. A. G. Haanen, Marianne B. Crijns, Myles J. Smith, Antien Mooyaart, Marlies Wakkee, Aniel Sewnaik, Dirk C. Strauss, Dirk J. Grunhagen, Cornelis Verhoef, Andrew J. Hayes, Winan J. van Houdt
Summary: This study describes the clinical course and prognosis of patients with lymph node metastases of cutaneous squamous cell carcinoma (cSCC) after lymph node dissection (LND). The study found that approximately one-third of the patients developed recurrent disease after LND, and the size of the primary tumor, number of positive lymph nodes, and immunosuppression were independent predictors of recurrence and disease-specific survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Dermatology
Madison Weber, Minh Binh Nguyen, Meng Yen Li, Pooja Flora, Masahiro Shuda, Elena Ezhkova
Summary: The regeneration of Merkel cells in adult skin and their origin from progenitor cells have been debated topics. Understanding Merkel cell regeneration is crucial for the study of Merkel cell carcinoma, a rare skin cancer, and its association with Merkel cell progenitors and polyomavirus. This study identified SOX9+ cells as postnatal Merkel cell progenitors and showed that they can be reprogrammed to express neuroendocrine markers by Merkel cell polyomavirus T antigens.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Review
Oncology
Christina V. Angeles, Michael S. Sabel
Summary: Merkel cell carcinoma (MCC) is an aggressive form of skin cancer that, while responsive to chemotherapy, often relapses and develops resistance, limiting the effectiveness of treatment. The management of advanced MCC has been significantly impacted by the introduction of checkpoint inhibitors. Ongoing research is focusing on immunotherapy for MCC in unresectable and metastatic cases, as well as exploring future immune-based strategies for this challenging cancer.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Frederico O. Gleber-Netto, Sameer Kini, Samantha Tam, Avi Benov, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Michael R. Migden, Erez N. Baruch, Guojun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study included 1258 patients with cutaneous head and neck squamous cell carcinoma and showed that the number of metastatic lymph nodes and the presence of extranodal extension are independent prognostic factors for disease-specific survival. Incorporating these factors into staging systems can improve the performance of the American Joint Committee on Cancer lymph node classification.
Article
Otorhinolaryngology
Leandro Luongo Matos, Renato Castro Capuzzo, Paola Andrea Galbiatti Pedruzzi, Terence Farias, Jose Wilson Mourao de Farias, Carlos Takahiro Chone, Hugo Fontan Kohler, Jose Guilherme Vartanian, Fernando Luiz Dias, Eduardo Vieira Couto, Fabio Roberto Pinto, Andre Lopes Carvalho, Luiz Paulo Kowalski
Summary: In a real-world scenario, sentinel lymph node biopsy is shown to be accurate and safe for patients with early lip and oral cavity squamous cell carcinoma, with similar results to elective neck dissection.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Pathology
Anna Szumera-Cieckiewicz, Daniela Massi, Angelo Cassisa, Mateusz Krzyzinski, Monika Dudzisz-Sledz, Przemyslaw Biecek, Piotr Rutkowski, Andrzej Marszalek, Mai P. Hoang, Piotr Donizy
Summary: This study aimed to determine the most sensitive immunohistochemical panel for detecting Merkel cell carcinoma (MCC) nodal metastases. The results showed that SATB2 as a first-line marker had the highest probability of detecting nodal metastases, and synaptophysin had superior significance in confirming the neuroendocrine origin of metastatic cells.
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Letter
Dermatology
Nooshin Bagherani, Bruce R. Smoller
DERMATOLOGIC THERAPY
(2018)
Letter
Dermatology
Nooshin Bagherani, Bruce R. Smoller
DERMATOLOGIC THERAPY
(2018)
Biographical-Item
Dermatology
Victor G. Prieto, Christopher R. Shea, Bruce R. Smoller
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Dermatology
Maryam Aghighi, Bruce R. Smoller
Summary: Hailey-Hailey disease is a hereditary skin condition characterized by blisters and erosions, with decreased expression of Galectin-3 potentially playing a role in the pathogenesis of the disease.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Review
Pathology
Numbereye Numbere, Tatsiana Pukhalskaya, Blythe Bowman, Katelynn Campbell, Bruce Smoller
Summary: Progressive nodular histiocytosis (PNH) is a rare condition characterized by the gradual emergence of yellowish-brown papules and nodules on the skin and mucous membranes. It presents distinct clinical and microscopic features, challenging the differential diagnosis with other histiocytoses.
CASE REPORTS IN PATHOLOGY
(2021)
Article
Dermatology
Cynthia Reyes Barron, Bruce R. Smoller
Summary: Mycosis fungoides (MF) is a subtype of primary cutaneous T-cell lymphoma (CTCL) with indolent course. A study assessed melanocyte loss in MF through immunohistochemistry, finding a decrease or focal loss of melanocytes in 50% of cases. Factors such as predominant neoplastic cell type, age, race, gender, and histologic features were not predictive of melanocyte loss.
Article
Dermatology
Tatsiana Pukhalskaya, Bruce R. Smoller, David M. Menke, Olayemi Sokumbi
Summary: Primary cutaneous gamma delta T-cell lymphoma (PCGD-TCL) is a rare and aggressive T-cell neoplasm. The cases presented in this study showed adnexotropic infiltrate with atypical lymphocytes expressing CD3, CD8 and CD56. One patient underwent CT and PET scans revealing multi-organ involvement.
Article
Dermatology
Cynthia Reyes Barron, Bruce R. Smoller
Summary: GLUT1, a membrane associated carrier protein involved in glucose transport, has shown increased expression in various tumor types. This study aimed to determine GLUT1 expression in cutaneous sebaceous lesions. Strong cytoplasmic staining of GLUT1 was observed in sebaceous carcinoma, while a gradient of staining intensity was seen in sebaceomas and sebaceous adenomas, and minimal staining in sebaceous hyperplasia.
Article
Dermatology
Chau M. Bui, Sumire Kitahara, Wonwoo Shon, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: PRAME is not expressed in cutaneous T-cell lymphomas (CTCLs), suggesting that the pathogenesis of CTCL is not mediated by PRAME. Further study is required to identify biomarkers that might aid in the diagnosis and prognostication of CTCLs.
Article
Dermatology
Hatice B. Zengin, Bahadir Yildiz, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: Our study failed to reveal possible TFE3 gene fusion by IHC staining in benign, atypical, and malignant chondroid syringomas. Although the negative staining in MCS suggests a genetic heterogeneity in this entity, further studies with larger case groups are needed for a more definitive conclusion.
Article
Dermatology
Hatice B. Zengin, Bahadir Yildiz, Tatsiana Pukhalskaya, Bruce R. Smoller
Summary: Melanocytic nevi in lymph nodes pose a diagnostic challenge and can be mistaken for metastases. The use of PRAME immunohistochemical stain can help differentiate between the two. FLI-1 immunohistochemical expression has shown variable sensitivity in malignant melanoma, while melanocytic nevi are reported to be negative. In this study, we examined lymph nodes with metastatic melanoma and benign deposits, and found that FLI-1/Melan-A dual staining is equally sensitive and specific as PRAME in distinguishing between the two. Larger studies are needed to confirm these significant results.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Dermatology
Hatice B. Zengin, Chau M. Bui, Kristin Rybski, Tatsiana Pukhalskaya, Bahadir Yildiz, Bruce R. Smoller
Summary: A recent study investigated the expression of TRPS1 in various sweat gland tumors, revealing a high expression in both malignant and benign tumors. However, there was differential staining among different types of sweat gland tumors, suggesting potential differences in cellular origin or differentiation.
Article
Dermatology
Chau M. M. Bui, Tatsiana Pukhalskaya, Bruce R. R. Smoller, Hatice Betul Zengin, Saleh Heneidi, Eric Vail, Elias Makhoul, Bonnie Balzer
Summary: This study presents a series of eight cases of digital papillary adenocarcinoma (DPA) with two distinct clinical presentations, morphologies, immunophenotypes, and molecular features. Four cases showed painless, slow-growing nodules with glandular structures, while the other four cases showed painful, rapidly growing masses with solid, tightly packed papillary architecture.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Article
Dermatology
Buket Bagci, Cansu Karakas, Harsimran Kaur, Bruce R. Smoller
Summary: Granuloma annulare (GA) is a benign inflammatory disease with different histologic patterns, while malignancy-associated granuloma annulare (MGA) is rarely associated with cancer. This study aimed to compare the clinical and histopathological differences between GA and MGA. It was found that MGA is more common in older individuals and affects the extremities, with chronic lymphocytic leukemia being the most common associated malignancy. The histopathological pattern of interstitial was more commonly seen in MGA, while necrobiotic pattern was more common in GA.
Article
Dermatology
Kristin J. Rybski, Hatice B. Zengin, Bruce R. Smoller
Summary: This study evaluates the immunohistochemical expression of TRPS1 in cutaneous neoplasms with follicular differentiation, including trichoblastoma, trichoepithelioma, and basal cell carcinoma. The study found that TRPS1 showed intermediate-to-high positivity in trichoblastoma and trichoepithelioma, while it was negative or sporadically positive in basal cell carcinoma.
