期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 360, 期 6, 页码 1054-1059出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201701316
关键词
Hydrogenation; iron; amination; homogeneous catalysis; imines
资金
- China Scholarship Council (CSC) [201608410107]
- Dipartimento di Chimica, Universita degli Studi di Milano
Here we report the catalytic transfer hydrogenation (CTH) of non-activated imines promoted by a Fe-catalyst in the absence of Lewis acid co-catalysts. Use of the (cyclopentadienone)iron complex 1, which is much more active than the classical Knolker complex' 2, allowed to reduce a number of N-aryl and N-alkyl imines in very good yields using iPrOH as hydrogen source. The reaction proceeds with relatively low catalyst loading (0.5-2mol%) and, remarkably, its scope includes also ketimines, whose reduction with a Fe-complex as the only catalyst has little precedents. Based on this methodology, we developed a one-pot CTH protocol for the reductive amination of aldehydes/ketones, which provides access to secondary amines in high yield without the need to isolate imine intermediates.
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