期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 1, 页码 185-191出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800855
关键词
Amide; Amine; Hydrogenation; Heterogeneous catalysis
A simple and general protocol was developed for selective conversion of amides into amines. Amides were converted into amide acetals and imido esters by O-alkylation and then hydrogenated without isolation into amines under very mild reaction conditions over standard hydrogenation catalysts. Triethyloxonium tertafluoroborate, methyl trifluoromethanesulfonate, dimethyl sulfate and ethyl chloroformate were validated as alkylating agent. The synthetic utility of this approach was demonstrated by the selective carbonyl reduction of peptide groups. Carbonyl reduction of peptide group proceeds chemoselective without racemization of the neighboring chiral center.
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