期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 356, 期 2-3, 页码 359-363出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300695
关键词
allenoates; asymmetric catalysis; chiral phosphines; Michael addition; oxindoles
资金
- National Basic Research Program of China (973 Program) [2010CB833300]
- National Natural Science Foundation of China [21032006, 203900502, 20532040, 21290180]
- Science and Technology Commission of Shanghai Municipality [11XD1406400]
A novel reaction between ethyl allenoate and oxindoles that enables the asymmetric synthesis of 3,3-bisubstituted oxindoles with our previously established bifunctional N-acyl aminophosphine catalysts is reported. These products bearing a chiral quaternary carbon center at the C-3 position of the oxindoles may have potential significance in the synthesis of related structures. The best performance of these processes provides adducts with 92% yield and 94% ee.
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