Regiospecific Synthesis of 1-Trifluoromethylisoquinolines Enabled by Photoredox Somophilic Vinyl Isocyanide Insertion

Tetrabutylammonium Iodide-Catalyzed Radical Alkoxycarbonylation of 2-Isocyanobiphenyls with Carbazates: Synthesis of Phenanthridine-6-carboxylates

(2014) Xiaoqing Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Metal-Free Photochemical Aromatic Perfluoroalkylation of α-Cyano Arylacetates

(2014) Manuel Nappi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 6-acyl phenanthridines by oxidative radical decarboxylation–cyclization of α-oxocarboxylates and isocyanides

(2014) Jie Liu et al.   CHEMICAL COMMUNICATIONS

tert-Butyl peroxybenzoate (TBPB)-mediated 2-isocyanobiaryl insertion with 1,4-dioxane: efficient synthesis of 6-alkyl phenanthridines via C(sp3)–H/C(sp2)–H bond functionalization

(2014) Jia-Jia Cao et al.   CHEMICAL COMMUNICATIONS

Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts

(2014) Heng Jiang et al.   CHEMICAL COMMUNICATIONS

Transition-metal-free, visible-light induced cyclization of arylsulfonyl chlorides with 2-isocyanobiphenyls to produce phenanthridines

(2014) Lijun Gu et al.   CHEMICAL COMMUNICATIONS

Radical Arylalkoxycarbonylation of 2-Isocyanobiphenyl with Carbazates: Dual C–C Bond Formation toward Phenanthridine-6-carboxylates

(2014) Changduo Pan et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Promoted Radical C–H Trifluoromethylation of Free Anilines

(2014) Jin Xie et al.   ORGANIC LETTERS

2-Trifluoromethylated Indoles via Radical Trifluoromethylation of Isonitriles

(2014) Bo Zhang et al.   ORGANIC LETTERS

Arylative Cyclization of 2-Isocyanobiphenyls with Anilines: One-Pot Synthesis of 6-Arylphenanthridines via Competitive Reaction Pathways

(2014) Zhonghua Xia et al.   ORGANIC LETTERS

Highly Regio- and Diastereoselective Synthesis of CF3-Substituted Lactones via Photoredox-Catalyzed Carbolactonization of Alkenoic Acids

(2014) Yusuke Yasu et al.   ORGANIC LETTERS

Visible-Light-Mediated Fluoroalkylation of Isocyanides with Ethyl Bromofluoroacetates: Unified Synthesis of Mono- and Difluoromethylated Phenanthridine Derivatives

(2014) Xiaoyang Sun et al.   ORGANIC LETTERS

Co(acac)2/O2-Mediated Oxidative Isocyanide Insertion with 2-Aryl Anilines: Efficient Synthesis of 6-Amino Phenanthridine Derivatives

(2014) Tong-Hao Zhu et al.   ORGANIC LETTERS

The Benzoyl Peroxide Promoted Dual C–C Bond Formation via Dual C–H Bond Cleavage: α-Phenanthridinylation of Ether by Isocyanide

(2014) Lei Wang et al.   ORGANIC LETTERS

Photoredox-Induced Three-Component Oxy-, Amino-, and Carbotrifluoromethylation of Enecarbamates

(2014) Aude Carboni et al.   ORGANIC LETTERS

Trifluoromethylation by Visible-Light-Driven Photoredox Catalysis

(2014) Takashi Koike et al.   TOPICS IN CATALYSIS

Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor

(2014) B. Patel et al.   RSC Advances

Direct Trifluoromethylation of the CH Bond

(2013) Hui Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Sandmeyer Trifluoromethylation of Arenediazonium Tetrafluoroborates

(2013) Grégory Danoun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlled Trifluoromethylation Reactions of Alkynes through Visible-Light Photoredox Catalysis

(2013) Naeem Iqbal et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Photocatalyzed Meerwein Arylation: Classic Reaction of Aryl Diazonium Salts in a New Light

(2013) Durga Prasad Hari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkene Trifluoromethylation Coupled with CC Bond Formation: Construction of Trifluoromethylated Carbocycles and Heterocycles

(2013) Hiromichi Egami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of 6-Alkylated Phenanthridine Derivatives Using Photoredox Neutral Somophilic Isocyanide Insertion

(2013) Heng Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

6-Trifluoromethyl-Phenanthridines through Radical Trifluoromethylation of Isonitriles

(2013) Bo Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-induced synthesis of a variety of trifluoromethylated alkenes from potassium vinyltrifluoroborates by photoredox catalysis

(2013) Yusuke Yasu et al.   CHEMICAL COMMUNICATIONS

Room temperature decarboxylative trifluoromethylation of α,β-unsaturated carboxylic acids by photoredox catalysis

(2013) Pan Xu et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Generation of CF3-Containing Epoxides and Aziridines by Visible-Light-Driven Trifluoromethylation of Allylic Alcohols and Amines

(2013) Eunjin Kim et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible-Light-Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2-Trifluoromethyl Quinolines

(2013) Xichang Dong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible-Light-Induced Trifluoromethylation ofN-Aryl Acrylamides: A Convenient and Effective Method To Synthesize CF3-Containing Oxindoles Bearing a Quaternary Carbon Center

(2013) Pan Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Sulfonation and Trifluoromethylation of Enol Acetates with Sulfonyl Chlorides Using Visible-Light Photoredox Catalysis

(2013) Heng Jiang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Redox chemistry of trifluoromethyl sulfonium salts as CF3 radical sources

(2013) Satoshi Mizuta et al.   JOURNAL OF FLUORINE CHEMISTRY

Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery

(2013) Elizabeth A. Ilardi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

(2013) Satoshi Mizuta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photochemical activity of a key donor–acceptor complex can drive stereoselective catalytic α-alkylation of aldehydes

(2013) Elena Arceo et al.   Nature Chemistry

PhI(OAc)2-Mediated Synthesis of 6-(Trifluoromethyl)phenanthridines by Oxidative Cyclization of 2-Isocyanobiphenyls with CF3SiMe3 under Metal-Free Conditions

(2013) Qile Wang et al.   ORGANIC LETTERS

Trifluoromethylation of Allylsilanes under Photoredox Catalysis

(2013) Satoshi Mizuta et al.   ORGANIC LETTERS

De Novo Synthesis of Polysubstituted Naphthols and Furans Using Photoredox Neutral Coupling of Alkynes with 2-Bromo-1,3-dicarbonyl Compounds

(2013) Heng Jiang et al.   ORGANIC LETTERS

6-Phosphorylated Phenanthridines from 2-Isocyanobiphenyls via Radical C–P and C–C Bond Formation

(2013) Bo Zhang et al.   ORGANIC LETTERS

Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives

(2013) Yuanzheng Cheng et al.   ORGANIC LETTERS

6-Aroylated Phenanthridines via Base Promoted Homolytic Aromatic Substitution (BHAS)

(2013) Dirk Leifert et al.   ORGANIC LETTERS

Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis

(2013) Yusuke Yasu et al.   ORGANIC LETTERS

Transition Metal-Catalyzed C—H Trifluoromethylation

(2012) Fei Pan et al.   ACTA CHIMICA SINICA

Modular Synthesis of Phenanthridine Derivatives by Oxidative Cyclization of 2-Isocyanobiphenyls with Organoboron Reagents

(2012) Mamoru Tobisu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluoroform-Derived CuCF3for Low-Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air

(2012) Petr Novák et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tamed Arene and Heteroarene Trifluoromethylation

(2012) Tatiana Besset et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ortho-Trifluoromethylation of Functionalized Aromatic Triazenes

(2012) Andreas Hafner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light Photoredox Catalysis

(2012) Jun Xuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-component Oxytrifluoromethylation of Alkenes: Highly Efficient and Regioselective Difunctionalization of CC Bonds Mediated by Photoredox Catalysts

(2012) Yusuke Yasu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox functionalization of C–H bonds adjacent to a nitrogen atom

(2012) Lei Shi et al.   CHEMICAL SOCIETY REVIEWS

Direct CH Functionalization of Enamides and Enecarbamates by Using Visible-Light Photoredox Catalysis

(2012) Heng Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Developments on the Trifluoromethylation of (Hetero)Arenes

(2012) Xiao-Feng Wu et al.   Chemistry-An Asian Journal

Progress in Copper-Mediated Formation of Trifluoromethylated Arenes

(2012) Tianfei Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

(2012) Naeem Iqbal et al.   JOURNAL OF ORGANIC CHEMISTRY

Shining Light on Photoredox Catalysis: Theory and Synthetic Applications

(2012) Joseph W. Tucker et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups

(2012) Xing-Guo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in the Copper-Catalyzed Trifluoromethylation of Boronic Acids with CF3I

(2012) Yingda Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Method for the Cu-Mediated Trifluoromethylation of Arylboronic Acids with CF3 Radicals Derived from NaSO2CF3 and tert-Butyl Hydroperoxide (TBHP)

(2012) Yingda Ye et al.   ORGANIC LETTERS

Hydrophobically Assisted Separation-Friendly Mitsunobu Reaction

(2012) Xin-Shan Ye et al.   SYNLETT

Trifluoromethylation of heterocycles via visible light photoredox catalysis

(2012) Naeem Iqbal et al.   TETRAHEDRON LETTERS

Organocatalysis and CH Activation Meet Radical- and Electron-Transfer Reactions

(2011) Armido Studer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

(2011) Hiroyuki Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Trifluoromethylation of Heteroaromatic Compounds by Trifluoromethyl Sulfonium Salts

(2011) Cheng-Pan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α-Trifluoromethyl Carbonyl Compounds

(2011) Phong V. Pham et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling

(2011) Todd D. Senecal et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Direct C–H Oxidative Trifluoromethylation of Heteroarenes

(2011) Lingling Chu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A radical approach to diversity

(2011) Andrew T. Parsons et al.   NATURE

Catalysis for fluorination and trifluoromethylation

(2011) Takeru Furuya et al.   NATURE

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

(2011) David A. Nagib et al.   NATURE

Copper-Catalyzed Trifluoromethylation of Aryl and Vinyl Boronic Acids with An Electrophilic Trifluoromethylating Reagent

(2011) Tianfei Liu et al.   ORGANIC LETTERS

Silver-Mediated Trifluoromethylation of Arenes Using TMSCF3

(2011) Yingda Ye et al.   ORGANIC LETTERS

Palladium-Catalyzed C–H Perfluoroalkylation of Arenes

(2011) Rebecca N. Loy et al.   ORGANIC LETTERS

Innate C-H trifluoromethylation of heterocycles

(2011) Y. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

(2011) Michael T. Rudd et al.   ACS Medicinal Chemistry Letters

Combination Catalysis in Enantioselective Trifluoromethylation

(2010) Yan Zheng et al.   ADVANCED SYNTHESIS & CATALYSIS

Transition-Metal-Catalyzed Trifluoromethylation of Aryl Halides

(2010) Rylan J. Lundgren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shelf-stable electrophilic trifluoromethylating reagents: A brief historical perspective

(2010) Norio Shibata et al.   Beilstein Journal of Organic Chemistry

Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates

(2010) Jing Nie et al.   CHEMICAL REVIEWS

Visible light photoredox catalysis: applications in organic synthesis

(2010) Jagan M. R. Narayanam et al.   CHEMICAL SOCIETY REVIEWS

Aryl−CF3Bond-Forming Reductive Elimination from Palladium(IV)

(2010) Nicholas D. Ball et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(II)-Catalyzedortho-Trifluoromethylation of Arenes Using TFA as a Promoter

(2010) Xisheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visible light photocatalysis as a greener approach to photochemical synthesis

(2010) Tehshik P. Yoon et al.   Nature Chemistry

Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids

(2010) Lingling Chu et al.   ORGANIC LETTERS

The Palladium-Catalyzed Trifluoromethylation of Aryl Chlorides

(2010) E. J. Cho et al.   SCIENCE

The Organometallic Fluorine Chemistry of Palladium and Rhodium: Studies toward Aromatic Fluorination

(2009) Vladimir V. Grushin   ACCOUNTS OF CHEMICAL RESEARCH

Photoredox Catalysis with Visible Light

(2009) Kirsten Zeitler   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Trifluoromethylation of various aromatic compounds by CF3I in the presence of Fe(II) compound, H2O2 and dimethylsulfoxide

(2009) Tatsuhito Kino et al.   JOURNAL OF FLUORINE CHEMISTRY

Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis

(2009) David A. Nagib et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions

(2008) Jun-An Ma et al.   CHEMICAL REVIEWS

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Orthogonal Synthesis of Indolines and Isoquinolines via Aryne Annulation

(2008) Christopher D. Gilmore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active Trifluoromethylating Agents from Well-Defined Copper(I)−CF3Complexes

(2008) Galyna G. Dubinina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY