期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 18, 页码 3727-3735出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300698
关键词
asymmetric hydrogenation; catalyst recycling; ionic liquids; tetrahydroisoquinolines; tetrahydroquinolines
资金
- National Basic Research Program of China (973 Program) [2011CB808600]
- National Natural Science Foundation of China [21232008]
- Institute of Chemistry, Chinese Academy of Sciences [CMS-PY-201303]
Asymmetric hydrogenation reactions of quinolines and 3,4-dihydroisoquinolines using the chiral cationic ruthenium complex Ru(TsDPEN) [TsDPEN=N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine] as catalyst in neat imidazolium ionic liquids have been investigated. The catalytic performance was influenced by the anion of the ionic liquids for both substrate classes. A range of 2-alkyl-substituted 1,2,3,4-tetrahydroquinolines and 1-alkyl-substituted 1,2,3,4-tetrahydroisoquinolines was obtained in high yields with up to >99% ee. Interestingly, the hydrogenation of quinoline derivatives bearing a carbonyl group was selective for the CN (quinoline) over the CO (ketone) bonds, while such a unique chemoselectivity was not observed in methanol. Furthermore, the ruthenium catalysts could be easily recycled at least 5 times in the asymmetric hydrogenation of 3,4-dihydroisoquinoline by solvent extraction. To further facilitate the recovery of catalyst and reduce the use of organic solvent, a thin film of ionic liquid containing Ru(TsDPEN) was supported on silica gels. This supported ionic liquid-phase catalyst was effective in the asymmetric hydrogenation of quinoline, and could be recycled at least 6 times by simple filtration.
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