4.7 Article

Phosphine-Catalyzed [3+2] Annulation of Electron-Deficient Alkynes with N-Hydroxyphthalimide: Synthesis of 3a-Hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones

期刊

ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 14-15, 页码 2787-2792

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300426

关键词

[3+2]annulation reactions; electron-deficient alkynes; fused heterocycles; N-hydroxyphthalimide; nucleophilic phosphines

资金

  1. National Natural Science Foundation of China [21102179]
  2. Fundamental Research Funds for the Central Universities [JKZ2011011]

向作者/读者索取更多资源

The phosphine-catalyzed [3+2]annulation of electron-deficient alkynes with N-hydroxyphthalimide has been developed to give a variety of pharmaceutically attractive 3a-hydroxyisoxazolo[3,2-a]isoindol-8(3aH)-ones in good to excellent yields.

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