期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 5, 页码 847-852出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201201099
关键词
aniline derivatives; asymmetric synthesis; domino reactions; organocatalysis; quadruple cascade
资金
- Deutsche Forschungsgemeinschaft
- Fonds der Chemischen Industrie
An organocatalytic quadruple domino reaction initiated by a FriedelCrafts-type reaction of electron-rich arenes is described. The procedure involving up to three different Michael acceptors afforded highly functionalized cyclohexenecarbaldehydes bearing an aniline moiety, which are of great pharmaceutical and agricultural interest. This diphenylprolinol trimethylsilyl ether-catalyzed reaction also generates up to 4 contiguous stereocenters. It could be shown that various functional groups are tolerated and all products were obtained with very good diastereo- and excellent enantioselectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据