The Copper-Catalyzed Oxidative N-Acylation of Sulfoximines

An oxidative cross-coupling reaction between aldehydes and sulfoximines involving dual CH/NH functionalization has been developed. This reaction process is facilitated by a simple copper catalyst (1mol% loading) and tert-butyl hydroperoxide (TBHP) as the oxidant and proceeds under mild reaction conditions to afford a series of valuable N-acylated sulfoximine derivatives in excellent yields.