期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 8, 页码 1649-1660出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300132
关键词
atom transfer radical cyclization; ATRC; copper; cyclisation; -lactams; radicals
The cyclisation of N-allyl-N-substituted--polychloroamides is efficiently obtained through a copper-catalysed activators regenerated by electron transferatom transfer radical cyclisation process, with a metal load of only 0.5mol%. The redox catalyst is introduced in its inactive form as copper(II) chloride/[nitrogen ligand] complex, and continuously regenerated to the active copper(I) chloride/[nitrogen ligand] species by ascorbic acid. To preserve the catalyst integrity, the hydrochloric acid, released after each regeneration cycle, has been quenched by carbonate. The choice of the solvent is critical, the best performance being observed in ethyl acetate-ethanol (3:1).
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