Article
Chemistry, Organic
Xinmiao Huang, Ling Tang, Zhiyong Song, Shuangshuang Jiang, Xianmao Liu, Ming Ma, Bo Chen, Yuanhong Ma
Summary: A nickel catalysis system has been developed for the desulfonylative C(sp(2))-C(sp(2)) reductive cross-coupling reactions of aryl sulfone derivatives with aryl bromides to form diverse biaryl compounds. The isolated and confirmed Ar-Ni(II)-SO(2)CF3 complex with a phosphine ligand through oxidative addition of aryl sulfone to Ni(0) species provides solid evidence for understanding the C(Ar)-SO2 bond activation and reaction mechanism.
Article
Chemistry, Organic
Jing-Ao Ren, Jin-He Na, Chao Gui, Chengping Miao, Xue-Qiang Chu, Mengtao Ma, Hao Xu, Xiaocong Zhou, Zhi-Liang Shen
Summary: A nickel-catalyzed direct cross-coupling between unactivated aryl fluorides and aryl bromides was achieved. This one-pot reaction proceeds effectively at room temperature in THF, avoiding the use of preformed and sensitive organometallic reagents. The desired biaryls are produced in modest to good yields via C-F bond cleavage in the presence of a phosphine ligand and magnesium powder (with or without TMSCl).
Article
Chemistry, Organic
Ruiting Yang, Qiumin Xie, Qian Yan, Xiuli Zhang, Bao Gao
Summary: A novel approach for synthesizing thioesters using S-aryl thioformates as sources was reported, showing smooth transfer of the thioester moiety to aryl iodides. The reaction can be conducted at ambient temperature and tolerates a variety of substrates, with moderate to excellent yields. The scalability of this method was demonstrated through a gram-scale reaction with little change in chemical yield.
Article
Chemistry, Organic
Ruiting Yang, Qiumin Xie, Qian Yan, Xiuli Zhang, Bao Gao
Summary: A novel method for synthesizing thioesters using S-aryl thioformates as sources has been reported. The reaction achieved desirable yields of thioesters with various substrates under mild conditions. Gram-scale synthesis was also successful using this method.
Letter
Chemistry, Organic
Na-Na Ma, Xuan-Bo Hu, Yuan-Shuai Wu, Ya-Wen Zheng, Mengtao Ma, Xue-Qiang Chu, Hao Xu, Haiqing Luo, Zhi-Liang Shen
Summary: A direct cross-coupling reaction of aryl thioether with aryl bromide was successfully achieved using nickel salt, magnesium, and lithium chloride as catalysts in tetrahydrofuran solvent at room temperature. The one-pot reactions efficiently cleaved the C-S bond, yielding the desired biaryls in moderate to good yields, without the need for pregenerated or commercial organometallic reagents.
Article
Chemistry, Organic
Jin-He Na, Xiang Liu, Jia-Wen Jing, Jing Wang, Xue-Qiang Chu, Mengtao Ma, Hao Xu, Xiaocong Zhou, Zhi-Liang Shen
Summary: A step-economical and efficient one-pot reaction was developed for the direct cross-coupling of aryl fluorosulfate with aryl bromide. This reaction, conducted at room temperature in THF solvent, does not require the use of preprepared/commercial organometallic reagents. By utilizing nickel catalyst, magnesium turnings, and lithium chloride, the desired biaryls were obtained in moderate to good yields with reasonable functional group compatibility.
Article
Chemistry, Multidisciplinary
Travis J. DeLano, Sara E. Dibrell, Caitlin R. Lacker, Adam R. Pancoast, Kelsey E. Poremba, Leah Cleary, Matthew S. Sigman, Sarah E. Reisman
Summary: The study reports an asymmetric reductive cross-coupling reaction with good enantioselectivity using nickel-catalysis and a chiral BiOX ligand to synthesize alpha-arylesters under mild conditions. The reaction shows good yields and enantioselectivities, tolerates a wide range of functional groups, and the resulting products can be used to prepare pharmaceutically-relevant chiral building blocks. Additionally, a multivariate linear regression model was developed to quantify the influence of the alpha-chloroester substrate and ligand on enantioselectivity.
Article
Chemistry, Organic
Na-Na Ma, Jing-Ao Ren, Xiang Liu, Xue-Qiang Chu, Weidong Rao, Zhi-Liang Shen
Summary: The direct cross-couplings of aryl sulfonium salts with aryl halides using nickel as a reaction catalyst were successfully achieved. The reactions proceeded efficiently via C-S bond activation at ambient temperature, providing moderate to good yields, potentially serving as an attractive alternative to conventional cross-coupling reactions.
Article
Chemistry, Organic
Alec H. Christian
Summary: The metallaphotoredox-catalyzed C-S cross-coupling allows for the formation of biaryl thioethers from heteroaryl bromides and alpha-thioacetic acids. This method facilitates cross-coupling between building blocks containing reactive functional groups, nitrogen heterocycles, and pharmaceutically relevant scaffolds. Mechanistic experiments show a unique pathway for the C-S cross-coupling to occur.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Haoyu Li, Xinxin Tang, Jia Hao Pang, Xiangyang Wu, Edwin K. L. Yeow, Jie Wu, Shunsuke Chiba
Summary: This study reveals the use of polysulfide anions as visible light photoredox catalysts for aryl cross-coupling reactions. By photoexcitation of tetrasulfide dianions, single-electron reduction of aryl halides is achieved, leading to the participation of aryl radicals in cross-coupling, borylation, and hydrogenation reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Nanxing Gao, Yanshun Li, Dawei Teng
Summary: The structure of primary alkylated arenes is crucial for the molecular action of drugs and natural products. This study presents a nickel-catalyzed reaction that efficiently synthesizes primary alkylated arenes by cross-electrophile coupling of aryl bromides and primary alkyl bromides, demonstrating excellent tolerance towards functional groups such as ester, aldehyde, ketone, ether, benzyl, and imide.
Article
Chemistry, Physical
Hurunqing Liu, Xinglin Wang, Zhaohui Li
Summary: In this study, a Pd/ZnIn2S4 nanocomposite was found to be an efficient bifunctional catalyst for the synthesis of aryl thioethers via the coupling reaction between thiophenols and aryl halides. The reaction mechanism involves the light-initiated generation of thiyl radicals as important intermediates. This study provides a facile, green and economic strategy for the synthesis of aryl thioethers under mild conditions, highlighting the potential of semiconductor-based photocatalysis in organic syntheses.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Organic
Kartic Manna, Ranjan Jana
Summary: We describe a mild and highly selective palladium-catalyzed cross-electrophile coupling between aromatic diazonium salts and aryl iodides or diaryliodonium salts in a water-ethanol (2:1) medium. Mechanistic studies revealed the importance of ethanol in generating an active Pd(0) catalyst, and the counterion of the diazonium salt promotes the formation of a cationic Pd(II) species that facilitates subsequent oxidative addition to aryl iodides/diaryliodonium salts. The presence of silver(I) salt is crucial for maintaining the catalytic activity of palladium by removing iodide ions as precipitates.
Article
Chemistry, Multidisciplinary
Xia Hu, Ivan Cheng-Sanchez, Sergio Cuesta-Galisteo, Cristina Nevado
Summary: An electrochemically driven nickel-catalyzed enantioselective reductive cross-coupling reaction was developed for the synthesis of enantioenriched beta-aryl homoallylic amines with excellent E-selectivity. This reaction proceeds under mild conditions without the use of heterogeneous metal reductants and sacrificial anodes, employing constant current electrolysis with triethylamine as a terminal reductant. The reaction demonstrates remarkable stereocontrol, broad substrate scope, and excellent functional group compatibility, making it suitable for the late-stage modification of bioactive molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Fei Li, Weikang Xiong, Geyang Song, Yonggang Yan, Gang Li, Chao Wang, Jianliang Xiao, Dong Xue
Summary: A general and efficient photochemical C-N coupling method for (hetero)aryl chlorides with hydrazides is presented. The reaction is catalyzed by a Ni(II)-bipyridine complex and does not require an external photosensitizer, making it highly practical. This method demonstrates a wide substrate scope (54 examples) and excellent functional group tolerance, and has been successfully applied to the synthesis of rizatriptan.
Review
Chemistry, Medicinal
Kritika Laxmikeshav, Pooja Kumari, Nagula Shankaraiah
Summary: This review provides a comprehensive report on the design strategies of sulfur-bearing cytotoxic agents and their potential in anticancer therapy. The article discusses various sulfur-containing heterocyclic scaffolds and their cytotoxic effects through multiple mechanisms. The assessment of antiproliferative activities allows for a proficient evaluation of the structure-activity relationships of the synthesized molecules.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Sarthak Jhingran, Kritika Laxmikeshav, Sayali Mone, Venkata K. Rao, Nagula Shankaraiah
Summary: Cancer, as a global health issue, poses a significant threat to human lives. DNA, being one of the major targets in cancer chemotherapy, can be effectively targeted by phenanthrene and its derivatives through intercalation and inhibition of DNA synthesis enzymes. However, the development of novel chemotherapeutic agents is crucial due to off-target effects and resistance. This review summarizes the recent progress in the development of phenanthrene-based derivatives, focusing on synthetic strategies, conjugation with other pharmacophores, and metal complexes. The cytotoxicity evaluation against various carcinoma cell lines and computational studies are also discussed, highlighting the potential of these derivatives as cytotoxic agents in medicinal chemistry.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Organic
Jay Prakash Soni, Nayan Arvind Jadhav, Nagula Shankaraiah
Summary: This review focuses on the azido-reductive cyclization of organic azides and its significant insights. The review elaborates the extensive literature for synthesizing various heterocycles using chemoselective and straightforward protocols for azido-reduction with concomitant intramolecular cyclization. The azido-reductive cyclization strategy has been successfully applied in the synthesis of essential heterocycles and various iminosugars, drugs/APIs, and natural products embedding such heterocycles.
CURRENT ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Kritika Laxmikeshav, Akash P. Sakla, Stephy Elza John, Nagula Shankaraiah
Summary: A facile and proficient dithiocarbamation of imidazo[1,2-a]pyridines and other imidazoheterocycles is established using a copper(i) catalyst and molecular oxygen under microwave conditions, resulting in moderate to excellent yields. The synthesized derivatives have drug-like properties and good ADME/T profile, with compounds 3be and 3bb showing more potency towards MCF-7 human breast cancer cells compared to the standard drug 5-fluorouracil.
Article
Biochemistry & Molecular Biology
Jay Prakash Soni, G. Nikitha Reddy, Ziaur Rahman, Anamika Sharma, Akella Spandana, Regur Phanindranath, Manoj P. Dandekar, Narayana Nagesh, Nagula Shankaraiah
Summary: In this study, a series of new beta-carboline tethered indole-3-glyoxylamide derivatives were synthesized, which showed significant pharmacological properties and prominent cytotoxicity. The compounds exhibited remarkable cytotoxicity against human cancer cell lines, especially melanoma, and showed selective toxicity towards cancer cells compared to normal cells. The compounds induced apoptosis and showed potential as DNA binders and inhibitors of Topoisomerase II. Molecular modeling studies confirmed their excellent DNA intercalation potential. In addition, in silico analysis predicted the promising drug-like properties of the synthesized derivatives.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Kritika Laxmikeshav, Pooja Sharma, Manisurya Palepu, Pravesh Sharma, Ashutosh Mahale, Joel George, Regur Phanindranath, Manoj P. Dandekar, Onkar Prakash Kulkarni, Narayana Nagesh, Nagula Shankaraiah
Summary: A new series of carboxamide-bearing benzimidazole derivatives have been investigated for their cytotoxicity on selected human tumor cells. Compounds 10g and 10m showed selective cytotoxicity towards SK-Mel-28 skin cancer cells and were safe for human non-cancerous lung epithelial cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Stephy Elza John, Anamika Sharma, Shivani Gulati, Darshana Bora, Nagula Shankaraiah
Summary: In modern medicinal chemistry, a molecular hybridization approach was used to design and synthesize a new class of cis-stilbene-based 1,2,4-triazole/1,3,4-oxadiazole conjugates. These conjugates exhibited promising cytotoxicity against selected human cancer cell lines, with cis-stilbene-based 1,2,4-triazole conjugate 5a being the most effective against the A549 cell line. Mechanistic analysis revealed that 5a induced apoptosis, DNA damage, nuclear morphological changes, and ROS generation, and exhibited G2/M phase arrest and tubulin polymerization inhibition. Additionally, 5a showed no toxicity towards normal cells and demonstrated significant anti-cancer activity.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Kritika Laxmikeshav, Mone Sayali, Geetanjali Devabattula, Durgesh G. G. Valapil, Ashutosh Mahale, Pravesh Sharma, Joel George, Regur Phanindranath, Chandraiah Godugu, Onkar P. P. Kulkarni, Narayana Nagesh, Nagula Shankaraiah
Summary: A simple click protocol was used to synthesize 1,2,3-triazole-linked benzimidazoles as potential anticancer agents, which showed significant cytotoxicity against SK-Mel-28 cancer cells and no cytotoxicity against normal BEAS-2B cells. Compound 12j inhibited cellular migration, colony formation, and induced apoptosis in SK-Mel-28 cells.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Physical
Darshana Bora, Anamika Sharma, Stephy Elza John, Nagula Shankaraiah
Summary: A series of new combretastatin-oxindole derivatives were synthesized using (E)-bis(phenyl) acrylohydrazides and substituted isatins. The cytotoxic activity of these derivatives was evaluated against various cancer cell lines, and compound 9o showed potent anti-cancer activity against lung cancer cells. It induced changes in nuclear morphology and apoptosis, inhibited tubulin polymerization, and had a binding interaction with the 3E22 protein.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Akash P. Sakla, Biswajit Panda, Ashutosh Mahale, Pravesh Sharma, Kritika Laxmikeshav, Mursalim Ali Khan, Onkar Prakash Kulkarni, Chandraiah Godugu, Nagula Shankaraiah
Summary: In this study, regiospecific nucleophilic ring-opening of spiroaziridine oxindoles was performed to synthesize 3-substituted-thiooxindole derivatives as anticancer agents. Among the new compounds, 7d and 9c showed promising cytotoxic activity against HCT-116 cells with IC50 values of 6.73 ± 0.36 and 6.64 ± 0.95 μM, respectively. Further studies demonstrated significant alterations in nuclear and morphological characteristics, loss of mitochondrial membrane potential, and cell cycle arrest in G2-M phase for compound 9c. In addition, compound 9c exhibited tubulin polymerase inhibition with an IC50 value of 9.73 ± 0.18 μM, supported by docking interactions with tubulin.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Sravani Sana, Srinivas Reddy Dannarm, Ramya Tokala, Sowmya Dastari, Manda Sathish, Rahul Kumar, Rajesh Sonti, Nagula Shankaraiah
Summary: A sustainable synthetic protocol for the construction of color-tunable fluorescent molecules has been achieved via ruthenium-catalyzed multiple C-H activation/annulation. The strategy provides easy access to a library of fused heterocyclic frameworks with significant yields. A systematic investigation of photophysical properties has also been conducted for the discovery of new fluorophores.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Sravani Sana, Sowmya Dastari, Dannarm Srinivas Reddy, Ramya Tokala, Manda Sathish, Rajesh Sonti, Nagula Shankaraiah
Summary: A sustainable protocol using a photoredox-mediated dual catalytic copper/ruthenium system has been developed for the construction of unsymmetrical diarylamines. This approach allows for the easy access to medicinally relevant amines by sequentially arylating ammonia with various (hetero)aryl bromides. The resulting mono-arylated amines can undergo a copper-mediated cross-coupling with aryl boronic acids, enabling the synthesis of the tyrosine kinase inhibitor Imatinib in an eco-friendly manner.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Yellaiah Tangella, Jay Prakash Soni, Nagula Shankaraiah, Diana Abril, Manda Sathish
Summary: A versatile and efficient one-pot protocol has been developed for the synthesis of amides from easily accessible carboxylic acids and amines by employing trimethylsilyl azide as a promoter at room temperature. This reaction proceeds via an in situ generated acyl azide intermediates followed by the nucleophilic substitution of amines. Notably, most of the desired amides were obtained by simple filtration in excellent yields. The significant advantages like metal-free mild reaction conditions, higher yields, easily removable volatile byproducts, operational simplicity, and broad substrate scope make the transformation a useful contribution for the synthesis of biologically important amides.
Article
Biochemistry & Molecular Biology
Jay Prakash Soni, Shrilekha Chilvery, Anamika Sharma, G. Nikitha Reddy, Chandraiah Godugu, Nagula Shankaraiah
Summary: A series of 2-((3-(indol-3-yl)-pyrazol-5-yl)imino)thiazolidin-4-ones were designed and synthesized as potential and effective chemotherapeutic agents. Compound 6c exhibited the highest cytotoxicity against melanoma cancer cells and showed selectivity towards cancer cells. It induced early-stage apoptosis, arrested cell-cycle in the G2/M phase, and inhibited tubulin polymerization. Molecular modeling studies confirmed its stable binding to tubulin and interactions with active pocket residues.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Darshana Bora, Khan Mehtab Samir, Anamika Sharma, Shrilekha Chilvery, Sapana Bansod, Stephy Elza John, Mursalim Ali Khan, Chandraiah Godugu, Nagula Shankaraiah
Summary: In this study, a new series of cis-stilbene-1,2,3-triazole congeners were synthesized and evaluated for their potential anticancer and tubulin polymerization inhibition activity. The most active compound, 9j, showed selective cytotoxicity against colorectal cancer cells and induced apoptotic cell death. It also inhibited tubulin polymerization and exhibited G2/M phase cell cycle arrest.
RSC MEDICINAL CHEMISTRY
(2023)