期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 355, 期 14-15, 页码 2815-2821出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201300627
关键词
alcohols; asymmetric alkylation; bisoxazolines; copper; -keto esters
资金
- Spanish Ministerio de Ciencia e Innovacion (MICINN) [CTQ2010-20387, CSD2007-00006]
- FEDER
- Generalitat Valenciana [PROMETEO 2009/039]
- University of Alicante
- MICINN [JCI-2009-03710]
- University of Alicante [GRE12-03]
The copper(II) triflate-tert-butyl-bisoxazoline [Cu(OTf)(2)-t-Bu-BOX]-catalyzed asymmetric alkylation of -keto esters using free benzylic alcohols such as xanthydrols, as alkylating agents, is herein described for the first time. This green protocol renders in general the corresponding products with good results in terms of both yields and enantioselectivities using different keto esters, even when quaternary stereocenters were created. The scope, limitations and mechanistic aspects of the process are also discussed.
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