期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 354, 期 16, 页码 2954-2958出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200558
关键词
asymmetric catalysis; aza-Henry reaction; bifunctional catalysis; nitroalkanes; thioureas
The aza-Henry reaction is an efficient route to important chiral, vicinal diamines. Reports of the asymmetric version typically use electron-deficient acyclic imines. We report the first example of a catalytic, asymmetric aza-Henry reaction on an unfunctionalized cyclic imine that gives access to enantiopure diamine derivatives under experimentally straightforward conditions. The stereocentre is established through the initial nitromethane addition to the imine. The scalemic intermediate may be trapped through acylation, then crystallized.
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