Synthesis of Oxazolidin-2-ones via a Copper(I)-Catalyzed Tandem Decarboxylative/Carboxylative Cyclization of a Propiolic Acid, a Primary Amine and an Aldehyde

A facile approach to polysubstituted oxazolidin-2-ones is presented via a copper(I)-catalyzed tandem decarboxylative/carboxylative cyclization of a propiolic acid, a primary amine and an aldehyde (PA2-coulpling). This new multicomponent coupling constitutes an efficient methodology to provide the corresponding oxazolidin-2-ones in good yields.