期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 353, 期 14-15, 页码 2715-2720出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100066
关键词
asymmetric Michael addition; C-3-symmetrical species; catalyst recycling; cinchonine-squaramide
资金
- National Nature Science Foundation of China [20972121, 20872116, 91017005]
- Science Foundation of Ministry of Education for the New Teacher at the University of China [20090141120058]
- Ministry of Education of China [NCET-10-0625]
- National Mega Project on Major Drug Development [2009ZX09301-014-1]
A novel and recyclable catalyst, a C-3-symmetrical cinchonine-squaramide, has been developed for the asymmetric Michael addition of 1,3-dicarbonyl compounds to nitroalkenes. When using only 1 mol% of catalyst 1a for the reaction, high reaction yields with excellent enantioselectivities and diastereoselectivities (up to 96% yield, >99% ee, >99:1 dr) were achieved, in which the results for cyclic keto esters are the best ever achieved. Moreover, 1a can be easily recovered by simple precipitation and was used for six cycles without losing any selectivity and activity.
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