期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 353, 期 8, 页码 1241-1246出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000981
关键词
asymmetric catalysis; Michael addition; naphthoquinones; nitroalkenes; organocatalysis; squaramides
资金
- National Natural Science Foundation of China [21072020]
- Major Projects Cultivating Special Program in Technology Innovation Program [2011CX01008]
- Beijing Institute of Technology
A chiral squaramide-organocatalyzed, highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes has been developed. This reaction afforded the chiral naphthoquinones in excellent yields (up to 99%) and excellent enantioselectivity (up to 98% ee) under very low catalyst loading (0.25 mol%). This organocatalytic asymmetric Michael addition provides an efficient alternative route toward the synthesis of chiral functionalized naphthoquinones.
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