期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 353, 期 9, 页码 1457-1462出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201100105
关键词
asymmetric catalysis; copper; dipyridylphosphine ligands; hydrosilylation; ketones; polymethylhydrosiloxane
资金
- National Natural Science Foundation of China [21032003, 20672026]
- New Century Excellent Talents in Chinese University Program [NCET-07-0250]
- Natural Science Foundation of Zhejiang Province [R406378, Y406193]
In the presence of the inexpensive and non-toxic stoichiometric reductant polymethylhydrosiloxane (PMHS), the chiral copper(II)-dipyridylphosphine catalyst displayed high efficiency in the stereoselective hydrosilylation of a wide scope of aryl alkyl and heteroaromatic ketones under an air atmosphere and mild conditions in good to excellent ees (up to 97%). With certain amounts of sodium tert-butoxide and tert-butyl alcohol as additives, the reaction on a 21-g substrate scale can be conveniently completed within a few hours even at a substrate-to-ligand (S/L) ratio of 50,000.
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