期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 352, 期 9, 页码 1441-1445出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000071
关键词
aldehydes; allylic alkylation; Bronsted acids; enamine catalysis; organocatalysis
资金
- National Natural Science Foundation of China [20973051]
- Zhejiang Provincial Natural Science Foundation of China [Y4090139]
A very simple method was developed for the direct, palladium-free catalytic alpha-allylic alkylation of aldehydes. The direct organocatalytic intermolecular alpha-allylic alkylation reaction was mediated by a simple combination of Bronsted acid and enamine catalysis which furnished alpha-allylic alkylated aldehydes and cyclohexanone in high yields and chemoselectivities. The reaction conditions are mild and environmental friendly, the process is conducted under an atmosphere of air without the need for dried solvents, and water is the only side product of the allylic alkylation reaction.
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