期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 351, 期 16, 页码 2657-2666出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900448
关键词
aldehydes; allylic alcohols; isomerization; rhodium; N-tosylmines
资金
- Swedish Research Council
- Berzelius Center Exselent
The isomerisation of alkenols followed by reaction with aldehydes or N-tosylimines catalysed by rhodium complexes has been studied. The catalytically active rhodium complex is formed in situ from commercially available (cyclooctadiene)rhodium(l) chloride dimer [Rh(COD)Cl](2). The tandem process affords aldol and Mannich-type products in excellent yields. The key to the success of the coupling reaction is the activation of the catalysts by reaction with postassium tert-butoxide (t-BuOK), which promotes a catalytic cycle via alkoxides rather than rhodium hydrides. This mechanism minimises the formation of unwanted by-products. The mechanism has been studied by H-1 NMR spectroscopy and deuterium labelling experiments.
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