☆ 4.7 Article

Enantioselective Michael addition of dicyanoolefins to α,β-unsaturated aldehydes in aqueous medium

ADVANCED SYNTHESIS & CATALYSIS (2008)

期刊

ADVANCED SYNTHESIS & CATALYSIS

卷 350, 期 11-12, 页码 1781-1784

出版社

WILEY-V C H VERLAG GMBH

DOI: 10.1002/adsc.200800145

关键词

dicyanoolefins; enantioselective Michael addition; organocatalysts; unsaturated aldehydes; water

类别

Chemistry, Applied Chemistry, Organic

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摘要

A pool of water-compatible catalysts, namely dialkyl-(S)-prolinols, has been developed for the enantioselective direct vinylogous Michael addition reaction of vinylmalononitriles to alpha,beta-unsaturated aldehydes in aqueous medium. In many cases, the products can be obtained in almost optically pure form (> 96% ee) after a single recrystallization.

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