Article
Materials Science, Paper & Wood
Ryota Sato, Toshihiko Arita, Ryuichiro Shimada, Tomohiro Nohara, Keisuke Tabata, Kazuki Koseki, Kazuki Umemoto, Akito Masuhara
Summary: In this study, a core-shell structured composite of cellulose nanocrystal (CNC) and hydroxyapatite (HAp) (CNC@HAp) was successfully synthesized via a simple aqueous neutralization titration method. The method allows for easy control of the coating amounts of HAps and the resulting CNC@HAp pellets exhibit high mechanical strength, making them suitable for tissue engineering and medical purposes. The process and product of the study are environmentally-friendly, non-toxic, simple, and pure, demonstrating the potential for easy application in various fields.
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Xu Xue, Yan Hu, Yonghui Deng, Jiacan Su
Summary: Hydrogels are promising candidates for bone tissue engineering due to their unique 3D network structure. Injectable hydrogels based on biocompatible materials offer advantages in minimally invasive surgery and drug delivery. Advanced approaches and innovative ideas of bioactive hydrogels are expected to enhance the quality of life for patients with bone injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Janhavi Sonatkar, Balasubramanian Kandasubramanian
Summary: Bioactive glasses have been traditionally used for permeating and repairing bone defects, with 45S5 Bio glass being a prime artificial material developed by Larry Hench. These materials have exceptional biocompatibility and can form a HA coat in the body. Various synthesis techniques have been developed for bioactive glasses containing biocompatible polymers, aiming to review the modern evolution of glass for bone regeneration. These glasses can connect to osseous matter and restore new bone growth over time, ultimately restoring the ailing or defective bone to its original condition and function.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Michela Licciardello, Gianluca Ciardelli, Chiara Tonda-Turo
Summary: In this study, nanofibers based on a PCL-PANI blend were successfully fabricated using electrospinning technology. The resulting fibrous substrate showed good stability in physiological conditions. To improve the hydrophilicity of the surface, atmospheric plasma treatment was applied, resulting in a more favorable biological response. In vitro tests confirmed the viability and physiological-like morphology of cells cultured on the plasma treated PCL-PANI nanofibrous scaffolds.
BIOENGINEERING-BASEL
(2021)
Review
Biotechnology & Applied Microbiology
Xia Zhao, Daniel A. Hu, Di Wu, Fang He, Hao Wang, Linjuan Huang, Deyao Shi, Qing Liu, Na Ni, Mikhail Pakvasa, Yongtao Zhang, Kai Fu, Kevin H. Qin, Alexander J. Li, Ofir Hagag, Eric J. Wang, Maya Sabharwal, William Wagstaff, Russell R. Reid, Michael J. Lee, Jennifer Moriatis Wolf, Mostafa El Dafrawy, Kelly Hynes, Jason Strelzow, Sherwin H. Ho, Tong-Chuan He, Aravind Athiviraham
Summary: Cartilage, especially articular cartilage, is crucial for joint function and mobility, but has limited self-repair capacity. Cartilage tissue engineering (CTE) holds promise for repair, requiring effective chondrogenic factors, ample chondrogenic progenitors, and cell-friendly, biocompatible scaffold materials for success. Progress in these areas, along with advancements in 3D bio-printing, may improve clinical outcomes of cartilage repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Stephanie E. Doyle, Lauren Henry, Ellen McGennisken, Carmine Onofrillo, Claudia Di Bella, Serena Duchi, Cathal D. O'Connell, Elena Pirogova
Summary: This study successfully created degradable and homogenously distributed PCL-nHA scaffolds through regulation of PCL molecular weight and nHA concentration. The addition of nHA was found to increase the degradation rate of the PCL-nHA composites. The 45 and 80 kDa PCL-nHA groups showed good cytocompatibility, demonstrating their potential as tissue engineered implant materials.
Article
Chemistry, Multidisciplinary
Zelin Wang, Xidong Lin, Youchen Tang, Dongtian Miao, Junlong Huang, Yan Lu, Shaohong Liu, Ruowen Fu, Dingcai Wu
Summary: A simple and versatile defect-engineering strategy for the synthesis of high-grafting-density carbon-based polymer brushes (CBPBs) with highly stable C-C linkages via free radical polymerization is proposed in this study. This strategy involves the introduction and removal of nitrogen heteroatoms in the carbon skeletons via a simple temperature-Fmed heat treatment, leading to the formation of numerous carbon defects with reactive C=C bonds in the carbon substrates. The resulting CBPBs can endure strong acid and alkali environments and have potential applications in various areas.
Article
Polymer Science
Xiaoyue Pei, Liping Fang, Weiping Chen, Xin Wen, Libin Bai, Xinwu Ba
Summary: The study focuses on multifunctional smart hydrogels with dynamic covalent bonds, showing pH, temperature, glucose, and redox tetra-responsiveness, as well as AND logic gate response. The hydrogels exhibit excellent self-healing ability and have potential applications in sensors, actuators, controlled drug delivery, etc.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Applied
Salma M. Abdel-Hafez, Josef Zapp, Markus Gallei, Marc Schneider
Summary: This study selected maltodextrin (MD) as the material for producing nanoparticles due to its economic, non-toxic, biocompatible, and biodegradable properties. The MDs were modified through acetal modification, resulting in hydrophobic polymers with pH-dependent degradability. The synthesized acetalated MD (AcMD) polymers exhibited different thermal properties and lower glass transition temperatures. Uniform AcMD nanoparticles (NPs) with diameters ranging from 141 to 258 nm were produced through nanoprecipitation. These particles were loaded with a hydrophobic model drug, resveratrol, and showed high entrapment efficiency and drug loading. The degradation and release behavior of the particles were studied under different pH conditions, and their interaction with different cell lines was also investigated.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Chunhui Luo, Andi Guo, Yufei Zhao, Jing Sun, Zhibo Li
Summary: A nonswellable and biocompatible hydrogel was successfully fabricated from polyvinyl alcohol and chitosan through multiple physical interactions without harmful crosslinkers. The hydrogel demonstrated superior mechanical properties and anti-swelling property, making it an ideal material for biotechnological applications. Furthermore, the hydrogel showed good creep resistance upon external loading and cytocompatibility with HeLa cells, indicating its high potential for scale up and use in industrial applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Meng Xu, Haidong Zha, Run Han, Yaxin Cheng, Jiamao Chen, Ludan Yue, Ruibing Wang, Ying Zheng
Summary: In this study, pH-sensitive nanoparticles were used to deliver dihydroartemisinin (DHA) for tumor therapy in multiple ways. The nanoparticles generate lethal oxidants in the tumor microenvironment and induce cancer cell death through ferroptosis. This strategy differs from traditional approaches and exhibits efficient anticancer efficacy.
Article
Polymer Science
Zhaoquan Zheng, Bingyu Wang, Jing Chen, Yan Wang, Ziyue Miao, Cenyao Shang, Qiang Zhang
Summary: By incorporating sugar units into polymers through copper-mediated reactions, quaternized poly(ionic liquid)s with pendant saccharide were prepared, showing high antibacterial properties and low cytotoxicity. These polymers demonstrated high selectivity against bacteria and could potentially pave the way for water disinfectant and pathogen control applications.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Soheyla Karimi, Hossein Rasuli, Reza Mohammadi
Summary: In this study, a pH-sensitive drug delivery system using Alginate beads impregnated with Al-Cu layered double hydroxides supported copper metal-organic framework was prepared for controlled release of doxorubicin to breast cancer cells. The physicochemical properties of the beads were analyzed, and in vitro release studies showed controlled drug release with pH-response. Cytotoxicity tests showed that the Alg-DOX-Cu MOF-LDH beads had higher cytotoxicity effects on breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Parth Kadakia, Jules D. P. Valentin, Linda Hong, Samuel Watts, Owais Abdul Hameed, Michael Walch, Stefan Salentinig
Summary: This study introduces a pH-responsive antimicrobial nanomaterial made from bacteria-derived rhamnolipids and glycerol monooleate. pH- and composition-triggered colloidal transformations are reported and optimized for antimicrobial performance. The material kills Staphylococcus aureus and methicillin-resistant Staphylococcus aureus at pH 5.0 but not at pH 7.0. Furthermore, it inhibits Staphylococcus aureus biofilm formation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Gang Li, Zimeng Li, Lanlan Li, Shan Liu, Peng Wu, Min Zhou, Chenwen Li, Xiaodong Li, Gaoxing Luo, Jianxiang Zhang
Summary: This study reports a multifunctional hydrogel-based stem cell niche engineering strategy for the treatment of inflammatory bone loss. The synthesized stem cell niche possesses temperature-triggered gelling performance, inflammation/oxidative stress-resolving activity, stem-cell binding and survival-enhancing capacity, and osteogenesis-promoting capability. The effectiveness of this synthetic stem cell niche has been demonstrated in rats with periodontitis, and the mechanism is mainly achieved by the regulation of the GDF15/Atf3/c-Fos axis of the MAPK signaling pathway.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yixiang Pan, Jiajia Xu, Xue Cai, Xiaodong Li, Xiaoyan Wang
Summary: The study aimed to develop a novel copper-based pretreatment and investigate its effect on dentin bond strength when combined with universal adhesives. The results showed that the copper-based pretreatment combined with universal adhesives significantly improved dentin microtensile bond strength.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Materials Science, Biomaterials
Yuqing Lei, Jiajia Xu, Mengqi Pan, Yadong Chen, Xiaojun Li, Weipu Zhu, Chang Shu, Tianxiang Fang, Hongbing Liao, Qiaojie Luo, Xiaodong Li
Summary: Dentin bonding is a common type of tissue repair in oral health, but insufficient adhesive infiltration often leads to defects in the bonding interface and bacterial-related dental diseases. This study successfully constructed an antibacterial low-defect hybrid layer by using a hydrogel-like template on the dentin surface and electrostatically assembling polyethyleneimine, greatly improving the bonding effectiveness.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Qinghua Yang, Wendan Pu, Kaiyao Hu, Yi Hu, Zhiqiang Feng, Jiajun Cai, Chenwen Li, Lanlan Li, Zhenhua Zhou, Jianxiang Zhang
Summary: A reactive oxygen species (ROS)-responsive, transformable, and triple-targeting DL-3-n-butylphthalide (NBP) nanotherapy was developed for the treatment of ischemic stroke. The nanotherapy showed enhanced cellular uptake in brain endothelial cells and improved therapeutic effects for ischemic stroke. Furthermore, the nanotherapy targeted both injured endothelial cells and activated neurons/microglial cells, and normalized the pathological microenvironment, leading to better functional recovery.
Article
Chemistry, Multidisciplinary
Shan Liu, Wenle Wang, Peng Wu, Zhiyu Chen, Wendan Pu, Lanlan Li, Gang Li, Jianxiang Zhang, Jinlin Song
Summary: In this study, a pathogenesis-guided engineering approach is proposed to enhance bone defect repair using a multi-bioactive hydrogel therapy. The therapy effectively improves the osteoimmune environment and enhances osteogenic differentiation of stem cells. By incorporating self-assembled nanomicelles (PP5 NMs), a pro-osteogenic protein (rhBMP9), and a temperature-responsive hydrogel material, a multifunctional hydrogel therapy is developed. This therapy shows great potential for treating different inflammatory bone diseases by resolving inflammation and promoting bone regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hongjie Zhang, Tianxiang Fang, Xuxia Yao, Xiaodong Li, Weipu Zhu
Summary: Poly(ethylene terephthalate) (PET) is an important polymer with a high annual production. The development of PET recycling technologies is crucial for reducing environmental harm and carbon emissions. This study introduces a solid-state reaction using a novel hyperthermostable antibacterial monomer for PET waste upcycling. The reaction is catalyzed by residual catalysts in the waste and enables low-cost production of high-value recycled PET with strong and persistent antibacterial activity. This work provides a feasible and economic strategy for large-scale PET waste upcycling, with potential applications in the polymer industry.
ADVANCED MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
M. Pan, Z. Li, J. Xu, Y. Lei, C. Shu, W. Lao, Y. Chen, X. Li, H. Liao, Q. Luo, X. Li
Summary: In this study, it was found that the highly hydrated interface of the porous dentin matrix (DDM) can form a unique interface called confined liquid water, which is one of the main causes for the bonding durability problem in adhesive dentistry. By introducing three metal ions (Na+, Ca2+, and Cu2+), it was discovered that calcium and copper can rapidly release the confined water and significantly improve the penetration of hydrophobic adhesive monomers, leading to a decrease in defects and optimization of the tooth-resin bonding interface. This study provides a foundation for solving the core scientific issue of water residue and replacement in contemporary adhesive dentistry, both theoretically and practically.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Hanjing Zhangdi, Yanan Jiang, Yang Gao, Shuang Li, Ruiling Xu, Jing Shao, Jingyang Liu, Ying Hu, Xu Zhang, Xiaoyu Zhang, Lei Zhao, Jihan Qi, Xinyu Geng, Shizhu Jin
Summary: Bone marrow mesenchymal stromal cells (BMSCs) have a protective effect against liver cirrhosis by modulating the Creb3l1/lncRNA Kcnq1ot1/miR-374-3p/Fstl1 signaling pathway. The expression of lncRNA Kcnq1ot1 is upregulated in liver cirrhosis, and its knockdown attenuates the disease. Additionally, the transcription factor Creb3l1 plays a role in the regulation of Kcnq1ot1 expression.
Article
Chemistry, Multidisciplinary
Haiyan Chen, Wendan Pu, Xiankang Hu, Cheng Yang, Guanli Zhao, Houyuan Hu, Jianxiang Zhang
Summary: This article reports a mitochondrial-mimetic therapy for dilated cardiomyopathy (DCM) that efficiently targets the heart, cardiomyocytes, and myocardial mitochondria, effectively regulating mitochondrial homeostasis. By synthesizing a bioactive conjugate TPT and delivering it intravenously, TPTN can accumulate in the heart and primarily localize in the cardiomyocytes and myocardial mitochondria, alleviating DCM. By packaging TPTN into outer mitochondrial membrane-derived vesicles, a mitochondrial-mimetic therapy with enhanced targeting capability is created, providing notable therapeutic effects in DCM mice.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Applied
Hanwen Chu, Rui Sun, Jian Sheng, Xiaojun Li, Xiaodong Li, Weibin Wang, Lisong Teng, Weipu Zhu
Summary: Cancer is a major public health problem and chemotherapy is a main treatment method. However, traditional anticancer drugs have limitations such as poor selectivity, short half-life, and toxic side effects. Polymeric prodrugs with therapeutic moieties covalently bonding to polymers have gained interest due to their improved durability, targeting, and bioavailability. The complex chemical composition of polymeric prodrugs limits their clinical translation. An amphiphilic supramolecular polymeric prodrug based on host-guest interaction was designed and synthesized to self-assemble into nano-sized micelles for aqueous-based anticancer chemotherapy. This novel supramolecular polymeric prodrug combines the advantages of polymeric and small molecule prodrugs, and has potential in clinical chemotherapy.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Bingyu Chen, Wendan Pu, Jianxiang Zhang
ACS CENTRAL SCIENCE
(2023)
Article
Engineering, Biomedical
Jiajun Cai, Hui Tao, Huan Liu, Yi Hu, Songling Han, Wendan Pu, Lanlan Li, Gang Li, Chenwen Li, Jianxiang Zhang
Summary: Asthma is a serious global health concern. A nanotherapy called LaCD NP, based on a cyclic oligosaccharide-derived bioactive material, has been developed to simultaneously regulate multiple target cells related to neutrophilic asthma. LaCD NP effectively accumulated in the injured lungs of asthmatic mice and mainly distributed in neutrophils, macrophages, and airway epithelial cells, reducing inflammation and improving asthmatic symptoms. The nanotherapy also showed good safety performance and promising potential for treating neutrophilic asthma and other neutrophil-associated diseases.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Weiwei Lao, Lijie Fan, Qiao Zhang, Chaoqian Lou, Hang Li, Yanyan Li, Shuang Wu, Xiaojun Li, Qiaojie Luo, Weipu Zhu, Xiaodong Li
Summary: In this study, a fully biodegradable hydrogel, with excellent biological compatibility and mechanical properties, was prepared via thiol-ene click reactions using multifunctional poly(ethylene glycol) (PEG) derivatives. Rat bone marrow mesenchymal stem cells (rBMSCs) could survive, proliferate, and differentiate into osteogenic cells on/in the hydrogel. The hydrogel also effectively loaded rhBMP-2, promoting the proliferation and osteogenic differentiation of rBMSCs. Furthermore, in a rat calvarial critical-size defect model, the hydrogel loaded with rhBMP-2 and rBMSCs achieved successful repair and regeneration within 4 weeks.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Engineering, Biomedical
Lanlan Li, Bingyu Chen, Gang Li, Sheng Chen, Jianxiang Zhang
Summary: Despite limitations of currently available anti-inflammatory therapies, nanotherapies based on bioactive cyclodextrin (CD) materials show promise in treating inflammatory disorders. This review provides an overview of recent advancements in the development and applications of anti-inflammatory nanoparticles (NPs) based on bioactive CD materials, highlighting their potential in treating diverse inflammatory diseases.
ADVANCED NANOBIOMED RESEARCH
(2023)
