期刊
ADVANCED MATERIALS
卷 20, 期 24, 页码 4691-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.200800567
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资金
- Biodesign Institute at Arizona State University, Department of Energy [DE-FC36-05GO15016, DE-AC02-05CH11231]
- NSF [DGE-01 14434, CHE-0131222]
A patterned combinatorial library of peptide-grafted polymer affinity materials is screened for target protein binding. In situ light-directed synthesis is used to produce high-density libraries that allow for the screening in parallel within an area less than 1 cm(2). From these libraries, specific peptide/polymer combinations are identified with very high target protein affinity, enabling facile detection of the target at concentrations in the low picomolar range in the presence of excess competitor.
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