Interfering with Lactate-Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform

Multifunctional Efficiency: Extending the Concept of Atom Economy to Functional Nanomaterials

(2018) Ralph Freund et al.   ACS Nano

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting

(2016) Di-Wei Zheng et al.   ACS Nano

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nanoscale metal−organic frameworks for combined photodynamic & radiation therapy in cancer treatment

(2016) Jingjing Liu et al.   BIOMATERIALS

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Exploration of MOF nanoparticle sizes using various physical characterization methods – is what you measure what you get?

(2016) Patrick Hirschle et al.   CRYSTENGCOMM

Size-Controlled Synthesis of Porphyrinic Metal–Organic Framework and Functionalization for Targeted Photodynamic Therapy

(2016) Jihye Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy

(2016) Chieh-Cheng Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lactate metabolism is associated with mammalian mitochondria

(2016) Ying-Jr Chen et al.   Nature Chemical Biology

In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

(2016) Xiangzhao Ai et al.   Nature Communications

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer

(2016) Sunghee Park et al.   Cell Reports

H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

(2015) Huachao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery

(2015) Qiong Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

(2015) Yuhao Cheng et al.   Nature Communications

Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells

(2014) Han Xie et al.   Cell Metabolism

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

(2014) B. M. Bola et al.   MOLECULAR CANCER THERAPEUTICS

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

Relationships between LDH-A, Lactate, and Metastases in 4T1 Breast Tumors

(2013) A. Rizwan et al.   CLINICAL CANCER RESEARCH

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Construction of Ultrastable Porphyrin Zr Metal–Organic Frameworks through Linker Elimination

(2013) Dawei Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Synthesis and Biological Response of Size-Specific, Monodisperse Drug–Silica Nanoconjugates

(2012) Li Tang et al.   ACS Nano

Design of an “Active Defense” System as Drug Carriers for Cancer Therapy

(2012) Jing Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy

(2012) Hong Yeol Yoon et al.   BIOMATERIALS

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells

(2012) Christophe J. De Saedeleer et al.   PLoS One

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA