Multiscale mechanobiology: computational models for integrating molecules to multicellular systems

Multiscale impact of nucleotides and cations on the conformational equilibrium, elasticity and rheology of actin filaments and crosslinked networks

(2015) Tamara Carla Bidone et al.   Biomechanics and Modeling in Mechanobiology

A Biomechanical Model for Fluidization of Cells under Dynamic Strain

(2015) Tenghu Wu et al.   BIOPHYSICAL JOURNAL

Solid friction between soft filaments

(2015) Andrew Ward et al.   NATURE MATERIALS

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex

(2015) Jocelyn Étienne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structurally Governed Cell Mechanotransduction through Multiscale Modeling

(2015) John Kang et al.   Scientific Reports

Structural basis for the nonlinear mechanics of fibrin networks under compression

(2014) Oleg V. Kim et al.   BIOMATERIALS

Advances in the mechanical modeling of filamentous actin and its cross-linked networks on multiple scales

(2014) Michael J. Unterberger et al.   Biomechanics and Modeling in Mechanobiology

Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discrete Fiber Network Simulations

(2014) A.S. Abhilash et al.   BIOPHYSICAL JOURNAL

Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers

(2014) Hailong Wang et al.   BIOPHYSICAL JOURNAL

Probing the Stochastic, Motor-Driven Properties of the Cytoplasm Using Force Spectrum Microscopy

(2014) Ming Guo et al.   CELL

A computational model of the response of adherent cells to stretch and changes in substrate stiffness

(2014) Harikrishnan Parameswaran et al.   JOURNAL OF APPLIED PHYSIOLOGY

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Lateral junction dynamics lead the way out

(2014) Martin Behrndt et al.   NATURE CELL BIOLOGY

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

(2014) M. Reffay et al.   NATURE CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Nanophotonic trapping for precise manipulation of biomolecular arrays

(2014) Mohammad Soltani et al.   Nature Nanotechnology

A brief history of synthetic biology

(2014) D. Ewen Cameron et al.   NATURE REVIEWS MICROBIOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin

(2014) L. Rognoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional cell migration does not follow a random walk

(2014) P.-H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix

(2014) R. J. Petrie et al.   SCIENCE

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Impact of Dimensionality and Network Disruption on Microrheology of Cancer Cells in 3D Environments

(2014) Michael Mak et al.   PLoS Computational Biology

Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State

(2014) Eline Boghaert et al.   PLoS Computational Biology

Mechanical Cell-Matrix Feedback Explains Pairwise and Collective Endothelial Cell Behavior In Vitro

(2014) René F. M. van Oers et al.   PLoS Computational Biology

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials

(2013) Ingmar Schoen et al.   Annual Review of Materials Research

Fibers in the Extracellular Matrix Enable Long-Range Stress Transmission between Cells

(2013) Xiaoyue Ma et al.   BIOPHYSICAL JOURNAL

Equilibrium phase diagram of semi-flexible polymer networks with linkers

(2013) C. J. Cyron et al.   EPL

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

The Adherens Junction: A Mosaic of Cadherin and Nectin Clusters Bundled by Actin Filaments

(2013) Indrajyoti Indra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanical decision trees for investigating and modulating single-cell cancer invasion dynamics

(2013) Michael Mak et al.   LAB ON A CHIP

Quantifying cell-generated mechanical forces within living embryonic tissues

(2013) Otger Campàs et al.   NATURE METHODS

Molecular motors robustly drive active gels to a critically connected state

(2013) José Alvarado et al.   Nature Physics

Microfluidic mixer designed for performing single-molecule kinetics with confocal detection on timescales from milliseconds to minutes

(2013) Bengt Wunderlich et al.   Nature Protocols

A Computational Model for Collective Cellular Motion in Three Dimensions: General Framework and Case Study for Cell Pair Dynamics

(2013) Federico Frascoli et al.   PLoS One

Strain history dependence of the nonlinear stress response of fibrin and collagen networks

(2013) S. Munster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid disorganization of mechanically interacting systems of mammary acini

(2013) Q. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Dynamic Modeling of Cell Migration and Spreading Behaviors on Fibronectin Coated Planar Substrates and Micropatterned Geometries

(2013) Min-Cheol Kim et al.   PLoS Computational Biology

Collective Cell Motion in an Epithelial Sheet Can Be Quantitatively Described by a Stochastic Interacting Particle Model

(2013) Néstor Sepúlveda et al.   PLoS Computational Biology

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

(2012) Shawn P. Carey et al.   BIOMATERIALS

A Molecular Trajectory of α-Actinin Activation

(2012) Hengameh Shams et al.   BIOPHYSICAL JOURNAL

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Integrating focal adhesion dynamics, cytoskeleton remodeling, and actin motor activity for predicting cell migration on 3D curved surfaces of the extracellular matrix

(2012) Min-Cheol Kim et al.   Integrative Biology

FEBio: Finite Elements for Biomechanics

(2012) Steve A. Maas et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

An agent based model of integrin clustering: Exploring the role of ligand clustering, integrin homo-oligomerization, integrin–ligand affinity, membrane crowdedness and ligand mobility

(2012) Yousef Jamali et al.   JOURNAL OF COMPUTATIONAL PHYSICS

Collective cell migration: leadership, invasion and segregation

(2012) A. J. Kabla   Journal of the Royal Society Interface

Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device

(2012) Michael Mak et al.   LAB ON A CHIP

Collective motion

(2012) Tamás Vicsek et al.   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks

(2012) Carlos Borau et al.   PLoS One

Host epithelial geometry regulates breast cancer cell invasiveness

(2012) E. Boghaert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active contractility in actomyosin networks

(2012) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Migration of cells in a social context

(2012) S. Vedel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic rate-dependent elasticity and failure of soft fibrous networks

(2012) A. S. Abhilash et al.   Soft Matter

Dynamic Role of Cross-Linking Proteins in Actin Rheology

(2011) Taeyoon Kim et al.   BIOPHYSICAL JOURNAL

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels

(2011) Qingzong Tseng et al.   LAB ON A CHIP

Collective cell guidance by cooperative intercellular forces

(2011) Dhananjay T. Tambe et al.   NATURE MATERIALS

Criticality and isostaticity in fibre networks

(2011) Chase P. Broedersz et al.   Nature Physics

General Mechanism of Actomyosin Contractility

(2011) Nilushi L. Dasanayake et al.   PHYSICAL REVIEW LETTERS

Microfabricated Physical Spatial Gradients for Investigating Cell Migration and Invasion Dynamics

(2011) Michael Mak et al.   PLoS One

Quantitative Analysis of the Effect of Cancer Invasiveness and Collagen Concentration on 3D Matrix Remodeling

(2011) Dewi Harjanto et al.   PLoS One

Molecular motors stiffen non-affine semiflexible polymer networks

(2011) C. P. Broedersz et al.   Soft Matter

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration

(2011) Katarina Wolf et al.   TRENDS IN CELL BIOLOGY

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Active cellular materials

(2010) Frederick C MacKintosh et al.   CURRENT OPINION IN CELL BIOLOGY

A microfluidic system with optical laser tweezers to study mechanotransduction and focal adhesion recruitment

(2010) Peyman Honarmandi et al.   LAB ON A CHIP

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Optimal matrix rigidity for stress-fibre polarization in stem cells

(2010) A. Zemel et al.   Nature Physics

Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch

(2010) Cheng Chen et al.   PLoS One

Mechanical tugging force regulates the size of cell-cell junctions

(2010) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filamins in cell signaling, transcription and organ development

(2010) Alex-Xianghua Zhou et al.   TRENDS IN CELL BIOLOGY

Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function

(2009) Christopher J. Bettinger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

Phosphorylation Facilitates the Integrin Binding of Filamin under Force

(2009) Harvey S. Chen et al.   BIOPHYSICAL JOURNAL

Structural and Viscoelastic Properties of Actin/Filamin Networks: Cross-Linked versus Bundled Networks

(2009) K.M. Schmoller et al.   BIOPHYSICAL JOURNAL

Cell Traction Forces Direct Fibronectin Matrix Assembly

(2009) Christopher A. Lemmon et al.   BIOPHYSICAL JOURNAL

Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways

(2009) Viola Vogel et al.   CURRENT OPINION IN CELL BIOLOGY

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Mechanics of the F-actin cytoskeleton

(2009) Jonathan Stricker et al.   JOURNAL OF BIOMECHANICS

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Single-cell response to stiffness exhibits muscle-like behavior

(2009) D. Mitrossilis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An active biopolymer network controlled by molecular motors

(2009) G. H. Koenderink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Aster formation and rupture transition in semi-flexible fiber networks with mobile cross-linkers

(2009) Jan A. Åström et al.   Soft Matter

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

(2009) Matthew J. Paszek et al.   PLoS Computational Biology

Computational Analysis of Viscoelastic Properties of Crosslinked Actin Networks

(2009) Taeyoon Kim et al.   PLoS Computational Biology

Biophysics of Catch Bonds

(2008) Wendy E. Thomas et al.   Annual Review of Biophysics

Rheology of the Cytoskeleton

(2008) Mohammad R.K. Mofrad   Annual Review of Fluid Mechanics

Molecular Dynamics Study of Talin-Vinculin Binding

(2008) S.E. Lee et al.   BIOPHYSICAL JOURNAL

Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization

(2008) Paolo P. Provenzano et al.   BIOPHYSICAL JOURNAL

Mapping proteolytic cancer cell-extracellular matrix interfaces

(2008) Katarina Wolf et al.   CLINICAL & EXPERIMENTAL METASTASIS

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Percolation in a network with long-range connections: Implications for cytoskeletal structure and function

(2008) Paulo S.P. Silveira et al.   PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Strain hardening, avalanches, and strain softening in dense cross-linked actin networks

(2008) Jan A. Åström et al.   PHYSICAL REVIEW E

Out-of-Equilibrium Microrheology inside Living Cells

(2008) Claire Wilhelm   PHYSICAL REVIEW LETTERS

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology

Molecular Mechanics of Filamin's Rod Domain

(2007) Kevin S. Kolahi et al.   BIOPHYSICAL JOURNAL