期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 64, 期 6, 页码 515-522出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2011.07.004
关键词
Tight junction; Absorption enhancer; Occludin; Claudin; Paracellular transport
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21689006]
- Ministry of Health, Labor and Welfare of Japan
- Japan Society for the Promotion of Science for Young Scientists
- Grants-in-Aid for Scientific Research [21689006] Funding Source: KAKEN
Epithelium covers the body and, therefore, separates the inner body from the outside environment. Passage across the epithelium is the first step in drug absorption. Tight junctions (TJs) seal the space between adjacent epithelial cells and prevent the free movement of solutes through the paracellular space. Modulation of the epithelial barrier is the most important strategy for enhancing drug absorption. Development of the strategy has accelerated with progress in understanding of the biology of the TJ seal. The first-generation absorption enhancers were screened on the basis of their absorption-enhancing activity in vivo. However, TJs were not well understood initially. The identification of TJ components, including those based on occludin and claudins, has led to the development of new strategies for drug absorption. Accumulation of knowledge of claudins has provided new insights into the paracellular transport of drugs. This review examines the relationship between advances in understanding of TJ biology and paracellular transport of drugs and discusses progress in the development of mucosal absorption enhancers. (C) 2011 Elsevier B.V. All rights reserved.
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