Review
Nanoscience & Nanotechnology
Anseo Choi, Kaila Javius-Jones, Seungpyo Hong, Hansoo Park
Summary: Nanoparticle-based drug delivery systems have limitations in tumor targeting and therapeutic outcomes. Cell-based drug delivery systems, using blood cells, immune cells, and stem cells with natural tumor tropism and low immunogenicity, provide a solution to these problems. In this review, we discuss the benefits and drawbacks of cell-based therapies, as well as their mechanisms in tumor microenvironments. Additionally, we summarize different strategies for loading therapeutic agents onto or inside circulating cells, and their current applications in disease treatments.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Alaa Khattab, Abdulhakim Nattouf
Summary: This study aims to control the delivery of Tazarotene (TZR) through a microsponge-based gel to reduce adverse effects. By adopting the emulsion solvent diffusion methodology, different formulations of TZR microsponges were developed by varying the concentrations of polymer and emulsifier. The T1 and T3 microsponge formulations showed superior production yield and entrapment efficiency, suitable for dermal application. The optimal formulation, T8 microsponge formulation gel, released 87.63% of TZR over 12 hours.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Masamitsu Kono, Nafisa K. K. Umar, Saori Takeda, Makiko Ohtani, Daichi Murakami, Hideki Sakatani, Fumie Kaneko, Denisa Nanushaj, Muneki Hotomi
Summary: Despite the success of pneumococcal conjugated vaccine and amoxicillin treatment, acute otitis media remains a medical concern. Failure of antimicrobial treatment is influenced by various factors, leading to the need for novel strategies utilizing drug delivery systems to target the causative pathogens effectively in the middle ear.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Cristina Scomoroscenco, Mircea Teodorescu, Adina Raducan, Miruna Stan, Sorina Nicoleta Voicu, Bodgan Trica, Claudia Mihaela Ninciuleanu, Cristina Lavinia Nistor, Catalin Ionut Mihaescu, Cristian Petcu, Ludmila Otilia Cinteza
Summary: This study aimed to develop and characterize new gel microemulsions for topical cosmetic applications, using grape seed oil and three different water-soluble polymers. Physico-chemical characterization and cytotoxicity evaluation showed that the gel microemulsions could effectively incorporate and control the release of hydrophobic active ingredients.
Review
Pharmacology & Pharmacy
Anita Ioana Visan, Rodica Cristescu
Summary: Therapeutic polysaccharide-based coatings have the potential to transform medical implants into drug delivery systems. However, further research is needed to fully understand the drug degradation/release profiles of these coatings before they can be used in clinical applications. This review paper provides a comprehensive description of the benefits and challenges of polysaccharide-based coatings, discusses the latest advances in drug delivery using different types of polysaccharide coatings, and gives recommendations for future research to accelerate the translation of polysaccharide-based drug delivery systems from the laboratory to the clinic.
Article
Materials Science, Biomaterials
Daniela Diaz-Zepeda, Rene D. Peralta-Rodriguez, Bertha Puente-Urbina, Gladis Cortez-Mazatan, H. Ivan Melendez-Ortiz
Summary: Oil-in-water microemulsions (o/w MEs) coated with chitosan were successfully used as new curcumin delivery systems, with ternary phase diagrams helping to determine their formation conditions. The addition of chitosan increased the stability of the microemulsions, and curcumin was found to be released most effectively under acidic conditions.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Review
Pharmacology & Pharmacy
Umme Hani, Riyaz Ali M. Osmani, Sabina Yasmin, B. H. Jaswanth Gowda, Hissana Ather, Mohammad Yousuf Ansari, Ayesha Siddiqua, Mohammed Ghazwani, Adel Al Fatease, Ali H. Alamri, Mohamed Rahamathulla, M. Yasmin Begum, Shadma Wahab
Summary: This paper discusses the application of nanotechnology in stomach cancer treatment, focusing on the latest advancements and ongoing research in nanotechnology-based drug delivery. By improving drug absorption, pharmacokinetics, and efficacy, nanotechnology enables more precise and effective treatment.
Review
Chemistry, Applied
Malihe Pooresmaeil, Hassan Namazi
Summary: This review discusses the issues with conventional drug administrations and the application of carboxymethyl starch (CMS) in drug delivery. It summarizes the recent advances and prospects of CMS-based drug delivery systems, aiming to provide comprehensive information for overcoming issues with traditional drug delivery systems.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Natalia Zashikhina, Sergei Gladnev, Vladimir Sharoyko, Viktor Korzhikov-Vlakh, Evgenia Korzhikova-Vlakh, Tatiana Tennikova
Summary: The covalent conjugation of dexamethasone with polymeric carriers is a promising strategy to overcome its limitations. In this study, self-assembling amphiphilic polypeptides were proposed as potential delivery systems for intravitreal delivery. Nanoparticles were prepared using different polypeptides and characterized in terms of size, polydispersity, and zeta potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Anna Froelich, Tomasz Osmalek, Barbara Jadach, Vinam Puri, Bozena Michniak-Kohn
Summary: Nose-to-brain drug delivery has gained significant attention as a route to deliver drugs directly to the central nervous system, bypassing the blood-brain barrier. Challenges include the small volume of the nasal cavity and limited drug absorption, which can be addressed by using drug carriers to enhance delivery efficiency.
Article
Public, Environmental & Occupational Health
Faranak Dehghani, Nafiseh Farhadian, Vahid Mashayekhi Goyonlo, Omid Ahmadi
Summary: This study developed a new topical administration by using a nanostructured lipid carrier (NLC)-based hydrogel to deliver Glucantime, which significantly improved the treatment outcomes of leishmaniasis. Compared with the commercial ampule, this formulation showed significant improvements in reducing the size of leishmaniasis wounds, lowering the number of parasites in lesions, liver, and spleen.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Review
Biochemistry & Molecular Biology
R. Bharathi, S. Shree Ganesh, G. Harini, Kumari Vatsala, R. Anushikaa, S. Aravind, S. Abinaya, N. Selvamurugan
Summary: The bone tissue engineering approach becomes necessary for treating large bone defects when the tissue damage exceeds the body's inherent regenerative ability. Chitosan is a promising bone scaffold material that supports cell attachment, proliferation, and mineralization of the bone matrix. Smart drug delivery scaffolds based on chitosan have been developed to respond to environmental stimuli and provide localized sustained drug delivery in the area of large bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Jing Yuan, Ningning Zhou, Jieyu Wu, Tianxiang Yin, Yunbin Jia
Summary: In this study, six CHAAILs were synthesized and found to enhance the solubility and permeability of ferulic acid and puerarin. Additionally, CHAAILs demonstrated lower cytotoxicity compared to traditional ionic liquids.
Article
Chemistry, Applied
Kajal Ghosal, Robin Augustine, Angelika Zaszczynska, Mrinmoy Barman, Amrita Jain, Anwarul Hasan, Nandakumar Kalarikkal, Pawel Sajkiewicz, Sabu Thomas
Summary: Triaxial electrospinning is a widely studied process for forming nanofibers, particularly in drug delivery systems. It enables the formation of complex nanostructures, resolves limited drug solubility issues, and controls drug release kinetics. This method has great potential in developing sophisticated nanomaterials for specific drug delivery applications.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Qi Chen, Di Wu, Yi Wang, Zhong Chen
Summary: This review introduces exosomes and their application in drug delivery systems. Exosomes have advantages of specific targeting, high biocompatibility, and non-toxicity, and can improve the constituents of traditional Chinese medicine. The review also discusses the challenges faced by exosomes in research and application.
