Article
Psychology, Biological
Joanna B. Thompson, Alan M. Daniel, Brenda G. Rushing, Mauricio R. Papini
Summary: In this study, animals exhibited transient rejection of reward after a reward downshift, followed by training in an operant licking task. The speed of recovery from the reward downshift was found to be associated with performance in the operant licking task, but not with genetic variations in the opioid receptor gene OPRM1.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Anesthesiology
Shathish Kumar, Ramasamy Kesavan, Sarath Chandra Sistla, Prasanth Penumadu, Harivenkatesh Natarajan, Sreekumaran Nair, Uppugunduri Chakradhara S. Rao, Vasuki Venkatesan, Pankaj Kundra
Summary: This study evaluated the association between 10 candidate SNPs in 9 genes and postoperative fentanyl dose, pain scores, and time for first analgesia. The results showed that certain SNPs were associated with higher fentanyl requirement and higher pain scores, while other SNPs were associated with lower pain scores and shorter time for first analgesia.
ANESTHESIA AND ANALGESIA
(2023)
Article
Biochemical Research Methods
Lorina Otte, Maurice Wilde, Volker Auwaerter, Katharina Elisabeth Grafinger
Summary: In 2009, new synthetic opioids with high affinity and potency for opioid receptors appeared on the market. Data on toxicological and toxicokinetic properties of these compounds are scarce. This study investigated the structure-activity relationships of eight U-opioids at mu- and kappa-opioid receptors. The results showed that different structural features were advantageous for activating the two receptors.
DRUG TESTING AND ANALYSIS
(2022)
Letter
Psychiatry
Alfonso Troisi
Summary: Research suggests that variation in the mu-opioid receptor gene is linked to attachment behavior in adults, with the A118G polymorphism and early maternal care interacting to influence levels of fearful attachment. Individuals carrying the minor 118G allele experience more pleasure in social situations and show lower levels of avoidant attachment compared to those with the A/A genotype.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Fernanda de Toledo Goncalves, Kevin Pacheco-Barrios, Ingrid Rebello-Sanchez, Luis Castelo-Branco, Paulo S. de Melo, Joao Parente, Alejandra Cardenas-Rojas, Isabela Firigato, Anne Victorio Pessotto, Marta Imamura, Marcel Simis, Linamara Battistella, Felipe Fregni
Summary: This study assessed the association between genetic polymorphisms related to chronic pain and pain-related outcomes and neurophysiological characteristics. The results showed that patients carrying polymorphisms on OPRM1 (A118G) and BDNF (G196A) genes were less likely to improve pain after rehabilitation, and these genetic polymorphisms also affected the improvement of cortical inhibition. The findings suggest the potential role of combining genetic and neurophysiological markers in guiding the treatment response in this population.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Rei Tanaka, Junya Sato, Hiroshi Ishikawa, Tetsu Sato, Michihiro Shino, Yasuhisa Ohde, Tetsumi Sato, Keita Mori, Akifumi Notsu, Sumiko Ohnami, Maki Mizuguchi, Takeshi Nagashima, Ken Yamaguchi
Summary: Despite significant advancements in cancer chemotherapy and immunotherapy, personalized opioid therapy research lags behind. This study found that OPRM1 and COMT gene variants influence the risk of somnolence as an adverse effect of opioid analgesic therapy.
Article
Biochemistry & Molecular Biology
Kristina Tchalova, Gentiana Sadikaj, D. S. Moskowitz, David C. Zuroff, Jennifer A. Bartz
Summary: Research shows that endogenous opioids are crucial in attachment bonds, with disruption leading to increased separation distress. A specific genetic variation (OPRM1) affects emotional experience and attachment behavior, impacting individuals' feelings of security in response to partners' quarrelsome behaviors.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Brian Reed, Mary Jeanne Kreek
Summary: Opioid addiction, like other addictive diseases, is profoundly influenced by genetics. Studies have affirmed the importance of genetics in susceptibility to opioid addiction, but the complexity of genetic interactions and differences in allelic frequencies across populations limit the predictive value of individual genetics variants.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Medicine, Legal
Katharina Elisabeth Grafinger, Maurice Wilde, Lorina Otte, Volker Auwaerter
Summary: Novel synthetic opioids (NSO) have emerged as a new class of drugs that target opioid receptors, potentially leading to serious adverse effects. Brorphine, a NSO, has been found to have different metabolites in vitro and in vivo, and acts as a potent MOR agonist and a weak KOR agonist.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Orthopedics
Wen-Ying Chou, Chien-Jen Hsu
Summary: The study revealed that female patients with OPRM1 G118G genotype required more morphine for post-operative pain control, while the genotype did not significantly affect morphine consumption in male patients.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2021)
Article
Medicine, General & Internal
Hongzhen Cheng, Xiaoyan Chu, Shenghua Yi
Summary: This study demonstrated the significant influence of OPRM1 A118G genotype on the dosage of morphine in advanced liver cancer patients, with GG genotype patients requiring higher morphine doses for pain control.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Pharmacology & Pharmacy
Intishar Kazi, Meghan J. Chenoweth, Didier Jutras-Aswad, Keith Ahamad, M. Eugenia Socias, Bernard Le Foll, Rachel F. Tyndale
Summary: Methadone and buprenorphine/naloxone are effective treatments for opioid use disorder, but individual responses can vary due to genetic factors. A study investigated the association between genetic variants and clinical outcomes in patients receiving these treatments for 24 weeks. The results showed that OPRM1 gene rs1799971 variant was associated with a better response to methadone treatment, with individuals carrying the AA genotype having more opioid-free urine screens.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Estibaliz Gonzalez de San Roman, Alberto Llorente-Ovejero, Jonatan Martinez-Gardeazabal, Marta Moreno-Rodriguez, Lydia Gimenez-Llort, Ivan Manuel, Rafael Rodriguez-Puertas
Summary: The study using a triple transgenic mouse model confirmed the association between neurolipid signaling and the pathogenesis of Alzheimer's disease, indicating that the changes in lipid regulation and signaling in different brain regions may help improve neurotransmission and alleviate myelin dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kevin M. Knight, Elizabeth G. Obarow, Wenyuan Wei, Sepehr Mani, Maria I. Esteller, Meng Cui, Ning Ma, Sarah A. Martin, Emily Brinson, Natalie Hewitt, Gaby M. Soden, Diomedes E. Logothetis, Nagarajan Vaidehi, Henrik G. Dohlman
Summary: In this study, the effects of 55 mutations on G protein structure and function were investigated, revealing four functionally distinct groups of mutants. These findings provide a more comprehensive understanding of disease-relevant mutations and suggest that GNAO1 disorder is composed of multiple mechanistically distinct disorders.
Article
Cell Biology
Marlena Typiak, Bartlomiej Rekawiecki, Krzysztof Rebala, Anna Dubaniewicz
Summary: The clinical outcome of sarcoidosis (SA) and tuberculosis (TB) is similar, but they are treated differently. Previous research has shown changes in the phagocytic activity of monocytes in SA and TB, with a higher expression of Fc?R receptors in these patients. However, despite the presence of these receptors, SA patients have high levels of immune complexes (ICs), indicating a dysfunction in Fc?R potentially caused by FCGR gene polymorphisms. This study analyzed the occurrence of FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B variants to differentiate between SA and TB and potentially serve as markers for SA progression.