期刊
ADDICTION BIOLOGY
卷 17, 期 2, 页码 437-440出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1369-1600.2011.00330.x
关键词
Cocaine self administration; cystine-glutamate exchange; drug seeking; habits; N-acetylcysteine; second-order schedule
资金
- United Kingdom Medical Research Council (MRC) [9536855]
- MRC/Wellcome Trust Behavioral and Clinical Neuroscience Institute
- MRC [G1002231] Funding Source: UKRI
- Medical Research Council [G1000183B, G0001354B, G1002231, G0001354] Funding Source: researchfish
N-acetylcysteine (NAC) has been suggested to have therapeutic potential in the treatment of drug addiction through its effects on brain glutamate homeostasis. Here we show that NAC treatment resulted in dose-dependent reductions in cocaine seeking at both early and late stages of acquisition and maintenance of cocaine-seeking behavior, while confirming it had no effect on cocaine reinforcement. The results indicate that NAC is able to significantly diminish the propensity to seek cocaine early and late in the development of addiction and, taken together with previous work, indicates significant potential in relapse prevention.
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