Article
Neurosciences
Ayman K. Hamouda, Malia R. Bautista, Lois S. Akinola, Yasmin Alkhlaif, Asti Jackson, Moriah Carper, Wisam B. Toma, Sumanta Garai, Yen-Chu Chen, Ganesh A. Thakur, Christie D. Fowler, M. Imad Damaj
Summary: The high sensitivity (HS) nAChR isoforms play a more prevalent role in mediating various brain functions and behavioral effects associated with nicotine use, while the low sensitivity (LS) nAChR isoforms have a limited impact on modulating body temperature and nociceptive responses. These findings will aid in the development of more selective and efficacious nAChR-based therapeutics for nicotine addiction treatment.
Article
Neurosciences
Natalia A. Quijano Carde, Jessica Shaw, Christina Carter, Seung Kim, Jerry A. Stitzel, Shyamala K. Venkatesh, Vijay A. Ramchandani, Mariella De Biasi
Summary: Alcohol and nicotine use during adolescence can lead to long-term neuroplastic changes that affect subsequent drug use. This study found that variation in the CHRNA5 gene is associated with drinking and smoking behaviors. Disruption of the alpha 5 nAChR subunit increases nicotine intake, particularly in adolescent female mice, while the effect on alcohol intake is more prominent in females. Additionally, adolescent alcohol or nicotine exposure can modulate subsequent intake of the opposite drug in adulthood, and this effect is influenced by sex and Chrna5 mutation.
Article
Multidisciplinary Sciences
Steven Decker, Gregory Davis, Imran Vahora, Alen Vukovic, Parth Patel, Asha Suryanarayanan
Summary: Alcohol use disorder is a common medical condition, and dFBr has been shown to reduce dependence on both nicotine and alcohol. The study found that dFBr selectively decreased ethanol consumption in rats while not affecting sucrose consumption. These findings suggest that dFBr may be an ideal candidate for treating both nicotine and alcohol abuse.
Article
Neurosciences
Amanda Jimenez-Pompa, Sara Sanz-Lazaro, Arik J. Hone, Lola Rueda-Ruzafa, Jose Medina-Polo, Carmen Gonzalez-Enguita, Jesus Blazquez, Cristobal de los Rios, J. Michael McIntosh, Almudena Albillos
Summary: The study found that varenicline increased the exocytosis of secretory vesicles in human and rat chromaffin cells, especially in the presence of nicotine. These results should be taken into consideration when using varenicline in nicotine addiction therapies.
Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Article
Medicine, General & Internal
Nancy A. Rigotti, Neal L. Benowitz, Judith Prochaska, Scott Leischow, Mitchell Nides, Brent Blumenstein, Anthony Clarke, Daniel Cain, Cindy Jacobs
Summary: This study evaluated the efficacy and tolerability of cytisinicline in smoking cessation. The results showed that cytisinicline, when administered for 6 or 12 weeks with behavioral support, demonstrated good effectiveness and tolerability in quitting smoking, offering new treatment options for nicotine dependence.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Behavioral Sciences
Michael T. Sapko, Taleen Hanania, Qing Chang, Jonathan C. Javitt
Summary: This study aimed to evaluate the abuse liability of D-cycloserine (DCS) using a self-administration paradigm. The results showed that DCS did not result in self-administration at any of the test doses and had similar behavior to the control group.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Louise M. Arildsen Jakobsen, Weiwei He, Nicholas Ditzel, Marianne Danielsen, Trine K. Dalsgaard, Niklas Rye Jorgensen, Peter Bollen, Hanne C. Bertram
Summary: This study investigated the effects of whey protein complexation of vitamin D-3 supplements on bone health in rats. The results showed that complexation did not improve the bioavailability of vitamin D-3 or have any significant impact on bone strength or microstructure.
Article
Nutrition & Dietetics
Jaesung Jung, Sujin Shin, Junkyu Park, Kyungjin Lee, Ho-Young Choi
Summary: The ethanol extract of Sanguisorbae radix (SRE) has a vasorelaxant effect on blood vessels and can lower blood pressure, making it a potential functional food for preventing and treating hypertension.
Review
Pharmacology & Pharmacy
Cecilia Gotti, Francesco Clementi
Summary: Cytisine, a natural compound mainly isolated from plants, has been used for smoking cessation and shows potential in treating neurological and non-neurological diseases. It interacts with neuronal nicotinic acetylcholine receptors and has diverse biological effects on addiction, mood regulation, and autonomic nervous system. Further research is needed to explore its mechanisms of action and potential applications.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
James E. Frampton
Summary: Pharmacological neuroactivation of the nasolacrimal reflex can increase endogenous tear film production, which is a novel approach to treating dry eye disease. Varenicline nasal spray, a water-soluble small-molecule agonist, has been shown to rapidly improve the signs and symptoms of DED and is well tolerated.
Article
Substance Abuse
Diana Carreno, Shahrdad Lotfipour
Summary: This study investigated the impact of sex on the acquisition of nicotine self-administration and nicotine-seeking behavior in adolescent rats. The results showed no sex differences in natural rewards, nicotine reinforcement, and reinstatement, suggesting that sex does not influence these behaviors when initiated during adolescence.
NICOTINE & TOBACCO RESEARCH
(2023)
Article
Neurosciences
Cassie M. Chandler, Jaren Reeves-Darby, Sherman A. Jones, Guanguan Li, Md T. Rahman, James M. Cook, Donna M. Platt
Summary: The study explored the role of GABAA receptors containing the alpha 5 subunit in relapse-like drinking behavior, indicating a potential new pharmacological target to prevent alcohol relapse. Results showed that the alpha 5GABA(A) receptor-selective inverse agonist L-655,708 inhibited the expression of ADE, while the alpha 5GABA(A) receptor-preferring agonist QH-ii-066 enhanced it.
Article
Biochemistry & Molecular Biology
Michelle Ren, Shahrdad Lotfipour
Summary: Communication between the brain and gut bacteria affects drug and addiction behaviors. Researchers investigated the impact of gut microbiota on fentanyl reinforcement and reward by depleting gut bacteria in adult male and female rats using antibiotics and allowing them to self-administer fentanyl. The results showed that antibiotic treatment increased fentanyl self-administration in males, but not females, at the lowest reinforcement schedule. Both males and females treated with antibiotics self-administered higher amounts of fentanyl at higher reinforcement schedules. Replenishing microbial metabolites restored normal fentanyl self-administration levels, indicating a significant relationship between gut microbiome and opioid use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Stephen Antwi, Daniel Oduro-Mensah, Jerry Asiedu-Larbi, Ebenezer Oduro-Mensah, Olga Quasie, Clara Lewis, David Darko-Obiri, Augustine Ocloo, Laud Kenneth Okine
Summary: The hydro ethanol extract of Holarrhena floribunda stem bark (HFE) has shown potential in managing chronic inflammation in a murine model. The extract demonstrated anti-arthritic effects, including reducing swelling, preventing spread of arthritis, and modulating inflammatory regulators. HFE could be considered as a drug for modulating the inflammatory response.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Clinical Neurology
Vatsalya Vatsalya, Joshua L. Gowin, Melanie L. Schwandt, Reza Momenan, Marion A. Coe, Megan E. Cooke, Daniel W. Hommer, Selena Bartlett, Markus Heilig, Vijay A. Ramchandani
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
Paul M. Klenowski, Matthew J. Fogarty, Arnauld Belmer, Peter G. Noakes, Mark C. Bellingham, Selena E. Bartlett
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Omkar L. Patkar, Arnauld Belmer, Joan Y. Holgate, Josephine R. Tarren, Masroor R. Shariff, Michael Morgan, Matthew J. Fogarty, Mark C. Bellingham, Selena E. Bartlett, Paul M. Klenowski
Article
Substance Abuse
Joshua L. Gowin, Vatsalya Vatsalya, Jonathan G. Westman, Melanie L. Schwandt, Selena Bartlett, Markus Heilig, Reza Momenan, Vijay A. Ramchandani
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2016)
Article
Neurosciences
Omkar L. Patkar, Arnauld Belmer, Josephine R. Tarren, Joan Y. Holgate, Selena E. Bartlett
NEUROSCIENCE LETTERS
(2016)
Article
Multidisciplinary Sciences
Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L. Patkar, Vincent Tam, Arnauld Belmer, Selena E. Bartlett
Article
Behavioral Sciences
Joan Y. Holgate, Hilary Garcia, Susmita Chatterjee, Selena E. Bartlett
BRAIN AND BEHAVIOR
(2017)
Review
Pharmacology & Pharmacy
Paul Klenowski, Michael Morgan, Selena E. Bartlett
BRITISH JOURNAL OF PHARMACOLOGY
(2015)
Article
Multidisciplinary Sciences
Arnauld Belmer, Omkar L. Patkar, Vanessa Lanoue, Selena E. Bartlett
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Arnauld Belmer, Ronan Depoortere, Kate Beecher, Adrian Newman-Tancredi, Selena E. Bartlett
Summary: This study demonstrates that stimulating the 5-HT1A receptor can reduce ethanol binge-drinking behavior and withdrawal-induced anxiety. Using a combination of pharmacological and chemogenetic approaches, the researchers identified the involvement of 5-HT1A autoreceptors and 5-HT neuronal function in regulating ethanol intake. They also discovered a serotonergic microcircuit originating from the MRN and projecting to the DG that specifically affects and modulates long-term ethanol consumption.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Nutrition & Dietetics
Kerri M. Gillespie, Eva Kemps, Melanie J. White, Selena E. Bartlett
Summary: This narrative review addresses the debate on the role of added and free sugars in human health and discusses various health conditions associated with sugar. The findings suggest that excessive added sugar consumption negatively affects human health and wellbeing, and the type and source of carbohydrates greatly influence their impact on health. Further research is needed to understand the complex relationship between sugar and health in diverse populations.
Article
Neurosciences
Joan Y. Holgate, Josephine R. Tarren, Selena E. Bartlett
Article
Behavioral Sciences
Paul M. Klenowski, Masroor R. Shariff, Arnauld Belmer, Matthew J. Fogarty, Erica W. H. Mu, Mark C. Bellingham, Selena E. Bartlett
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2016)
Review
Neurosciences
Joan Y. Holgate, Selena E. Bartlett