Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan R. Dillman, Samjhana Thapaliya, Jean A. Tkach, Andrew T. Trout
Summary: This study aimed to assess the agreement between UDFF and MRI PDFF measurements, and the results showed a strong correlation between the two. UDFF may have clinical implications in the detection of hepatic steatosis.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Juergen Machann, Maytee Hasenbalg, Julia Dienes, Robert Wagner, Arvid Kohn, Victor Fritz, Andreas L. Birkenfeld, Konstantin Nikolaou, Stephanie Kullmann, Fritz Schick, Martin Heni
Summary: The study evaluated short-term intraday variations of pancreatic fat (PF) and intrahepatic lipids (IHL) after a high-fat meal as well as medium-term changes after 5 days of high-caloric diet, showing that time of day and nutritional status have no significant influence on PF/IHL.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Nazarii Kobyliak, Oleh Dynnyk, Maryana Savytska, Oleksandr Solodovnyk, Oleksandr Zakomornyi, Oleksii Omelchenko, Anton Kushnir, Roman Titorenko
Summary: This study evaluates the accuracy and reproducibility of ultrasound steatometry with the Attenuation Coefficient measurement in assessing hepatic steatosis. The results show that this method has good correlation with MRI-PDFF and can provide valuable diagnostic information.
Article
Surgery
Qiaochu Qi, Allison K. Weinstock, Kalina Chupetlovska, Amir A. Borhani, Dana R. Jorgensen, Alessandro Furlan, Jaideep Behari, Michele Molinari, Swaytha Ganesh, Abhinav Humar, Andres Duarte-Rojo
Summary: This study found that MRI-PDFF reliably predicts outcomes for both living liver donors and recipients. Liver regeneration in living donors and post-surgical outcomes in recipients were not significantly associated with the severity of hepatic steatosis.
CLINICAL TRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Angeliki Meritsi, Emanuel Manesis, Panagiotis Koussis, Stamatia Rapti, Dimitra Latsou, Eustathios Tsitsopoulos, Hariklia Moshoyianni, Spilios Manolakopoulos, Dimitrios Pektasides, Anastasia Thanopoulou
Summary: Hepatic steatosis in type 2 diabetes is influenced by factors such as abdominal obesity and PNPLA3 molecular variability, which can have both direct and inverse associations.
METABOLIC SYNDROME AND RELATED DISORDERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahyun Kim, Mimi Kim, Chul-min Lee, Bo-Kyeong Kang, Dae Won Jun
Summary: This study aims to determine the best liver segments representing the whole-liver fat fraction (FF) in magnetic resonance imaging (MRI)-based measurement of the proton density fat fraction (PDFF). The study found considerable heterogeneity in hepatic steatosis between each segment of the liver, and the variability was significantly affected by the volume-weighted FF. The mean hepatic FF from segments V, VI, and IV could be used to estimate the volume-weighted FF of the whole liver, not only in the general population but also in patients with moderate or severe fatty liver.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Triay Bagur, Darryl McClymont, Chloe Hutton, Andrea Borghetto, Michael L. Gyngell, Paul Aljabar, Matthew D. Robson, Michael Brady, Daniel P. Bulte
Summary: Magnitude-based PDFF and R2* mapping is extended to calculate field inhomogeneity using phase images in a matrix form. The estimated field maps can update PDFF and R2* from magnitude fitting. The proposed method shows high accuracy and agreement compared with a reference complex-based method on UK Biobank subjects and exhibits robust field mapping at 3 T.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Physics, Multidisciplinary
Radim Korinek, Lorenz Pfleger, Korbinian Eckstein, Hannes Beiglboeck, Simon Daniel Robinson, Michael Krebs, Siegfried Trattnig, Zenon Starcuk, Martin Krssak
Summary: This study evaluated the feasibility of PDFF imaging using a multi-echo CSE-MRI technique at 7Tesla, showing its aptitude for MRI-based quantitation of PDFF in the liver. The results are the first step toward qMRI of the whole liver at 7Tesla with further improvements in hardware.
FRONTIERS IN PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tao Liu, Ping Dong, Jin-Rong Zhou, Jing Chen, Qian-Feng Luo, Shuang Long, Jia-Li Li, Dong Chen, Yuan-Sheng Li
Summary: This study aims to explore the characteristics of hepatic fat content in athletes and predict late gadolinium enhancement (LGE) using magnetic resonance imaging-proton density fat fraction (MRI-PDFF). The results showed that MRI-PDFF can assess liver fat content and predict cardiac fibrosis in athletes for risk stratification and follow-up.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giorgio Davico, Francesca Bottin, Alberto Di Martino, Vanita Castafaro, Fabio Baruffaldi, Cesare Faldini, Marco Viceconti
Summary: This study evaluates the repeatability of manual segmentation of hip muscle volumes on clinical MRI data and finds that repeated manual segmentations are highly similar to each other. However, shape and surface similarity decrease when muscle extremities are included in the segmentations.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Neurosciences
Raihaan Patel, Clare E. Mackay, Michelle G. Jansen, Gabriel A. Devenyi, M. Clare O'Donoghue, Mika Kivimaeki, Archana Singh-Manoux, Eniko Zsoldos, Klaus P. Ebmeier, M. Mallar Chakravarty, Sana Suri
Summary: This study examines the relationship between cognitive decline and brain structure in older age. By analyzing cognitive performance assessments and brain magnetic resonance images of a group of older individuals, the study identifies two distinct brain-cognition associations and highlights the complex relationship between cortical structure and cognitive abilities.
Article
Gastroenterology & Hepatology
Vlad Ratziu, Stephen A. Harrison, Veronique Loustaud-Ratti, Christophe Bureau, Eric Lawitz, Manal Abdelmalek, Naim Alkhouri, Sven Francque, Hugo Girma, Raphael Darteil, Harold Couchoux, Myles Wolf, Arun Sanyal, Jacky Vonderscher, Pietro Scalfaro
Summary: The study investigated the safety, tolerability, and efficacy of vonafexor in patients with suspected fibrotic NASH. Results showed that vonafexor was safe and induced significant reduction in liver fat, improvement in liver enzymes, weight loss, and a possible renal benefit.
JOURNAL OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Akin Abbasoglu, Musturay Karcaaltincaba, Ali Devrim Karaosmanoglu, Mustafa Nasuh Ozmen, Deniz Akata, Ilkay S. Idilman
Summary: This study aimed to evaluate the associations between hepatic, pancreatic steatosis, and lumbar spinal bone marrow fat determined by magnetic resonance imaging-proton density fat fraction in patients with no known or suspected liver disease. The study found that there were significant correlations between liver and pancreas, liver and lumbar, and pancreas and lumbar magnetic resonance imaging-proton density fat fraction in female patients. The prevalence of hepatic and pancreatic steatosis was 42.5% and 29%, respectively, and the prevalence of pancreatic steatosis was higher in male patients compared to female patients.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Syvaeri, Daniela Junker, Lisa Patzelt, Katharina Kappo, Loubna Al Sadat, Sonia Erfanian, Marcus R. Makowski, Hans Hauner, Dimitrios C. Karampinos
Summary: The study found significant differences in liver fat fraction changes in different liver lobes and Couinaud segments during a long-term lifestyle intervention study, with larger changes observed in the right liver lobe. This highlights the need to spatially resolve liver fat fraction changes in longitudinal studies.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Neurosciences
Katherine L. Bottenhorn, Carlos Cardenas-Iniguez, Kathryn L. Mills, Angela R. Laird, Megan M. Herting
Summary: As we delve into population-level developmental neuroscience, it is crucial to comprehend the variability within and between individuals in brain maturation and the origins of neurodevelopmental heterogeneity. Although large-scale, longitudinal neuroimaging studies have brought to light group-level neurodevelopmental trajectories, we still have limited knowledge regarding intra-and inter-individual differences. In this study, we aimed to quantify both forms of variability across various aspects of neurodevelopment during early adolescence in the ABCD Study and examine inter-individual variability based on age, sex, and puberty. Our findings offer novel insights into the differences in annualized percent change in macrostructure, microstructure, and functional brain development between the ages of 9 and 13. These results highlight that moderate age-related intra-individual changes exist, while age-related differences in inter-individual variability are only present in specific measures of cortical macro-and microstructure development. Furthermore, we observed greater inter-individual variability in brain development among mid-pubertal individuals, except for certain aspects of white matter development that demonstrated increased variability among prepubertal individuals in certain tracts. Additionally, although both sexes contribute to inter-individual differences in macrostructure and functional development in some brain regions, our findings do not strongly support the hypothesis of greater male-than-female variability. This work sheds light on pockets of individual variability in early adolescent brain development, while also highlighting regional differences in heterogeneity to facilitate future investigations on quantifying and probing nuances in normative development and deviations from it.
Article
Gastroenterology & Hepatology
Kimberly P. Newton, Laura A. Wilson, Nancy A. Crimmins, Mark H. Fishbein, Jean P. Molleston, Stavra A. Xanthakos, Cynthia Behling, Jeffrey B. Schwimmer
Summary: The study aimed to determine the incidence of type 2 diabetes (T2D) in children with nonalcoholic fatty liver disease (NAFLD) and identify associated risk factors. The results showed a high incidence rate of T2D in children with NAFLD, and being female, having a higher BMI z-score, and more severe liver histology were independent risk factors for T2D development.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Rohit Loomba, Daniel Q. Huang, Arun J. Sanyal, Quentin Mark Anstee, Michael Trauner, Eric J. Lawitz, Dora Ding, Lily Ma, Catherine Jia, Andrew Billin, Ryan S. Huss, Chuhan Chung, Zachary Goodman, Vincent Wai-Sun Wong, Takeshi Okanoue, Manuel Romero-Gomez, Manal F. Abdelmalek, Andrew Muir, Nezam Afdhal, Jaime Bosch, Stephen Harrison, Zobair M. Younossi, Robert P. Myers
Summary: In patients with non-alcoholic steatohepatitis (NASH), liver stiffness (LS) measured by vibration-controlled transient elastography (VCTE) can predict the progression of cirrhosis and the risk of liver decompensation.
Article
Gastroenterology & Hepatology
Darren Jun Hao Tan, Veronica Wendy Setiawan, Cheng Han Ng, Wen Hui Lim, Mark D. Muthiah, Eunice X. Tan, Yock Young Dan, Lewis R. Roberts, Rohit Loomba, Daniel Q. Huang
Summary: This study estimated sex differences in the burden of liver cancer globally and found that males have a higher burden. However, the incidence and death rates of NASH-associated liver cancer in females approach that of males.
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Philippe Mathurin, Helena Cortez-Pinto, Rohit Loomba
Summary: Global alcohol consumption has increased, leading to a rise in the incidence of alcohol-associated cirrhosis and hepatocellular carcinoma. Heavy alcohol consumption is a major cause of morbidity and mortality. Measures are needed to reduce the burden of alcohol-related liver diseases.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Rebecca W. Zeng, Jie Ning Yong, Darren J. H. Tan, Clarissa E. Fu, Wen Hui Lim, Jieling Xiao, Kai En Chan, Caitlyn Tan, Xin Lei Goh, Douglas Chee, Nicholas Syn, Eunice X. Tan, Mark D. Muthiah, Cheng Han Ng, Nobuharu Tamaki, Sung Won Lee, Beom Kyung Kim, Mindie H. Nguyen, Rohit Loomba, Daniel Q. Huang
Summary: An updated meta-analysis suggests that the use of statins and aspirin is associated with a reduced risk of hepatocellular carcinoma, while the use of metformin is not. These findings have implications for future clinical trial design.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Suzanne Sharpton, Kuangda Shan, Ricki Bettencourt, Miryoung Lee, Joseph B. B. McCormick, Susan P. P. Fisher-Hoch, Rohit Loomba
Summary: This study assessed the risk of significant hepatic fibrosis in first-degree relatives of Mexican Americans with hepatocellular carcinoma (HCC). The results showed a high prevalence of significant fibrosis and definite hepatic steatosis in first-degree relatives, particularly those with diabetes. Screening for liver disease could benefit this population.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Veeral Ajmera, Sandra Cepin, Kaleb Tesfai, Heather Hofflich, Karen Cadman, Scarlett Lopez, Egbert Madamba, Ricki Bettencourt, Lisa Richards, Cynthia Behling, Claude B. Sirlin, Rohit Loomba
Summary: This study evaluated the prevalence of advanced fibrosis and cirrhosis in patients with T2DM, and found that the prevalence of fibrosis was 14% and cirrhosis was 6%. These results highlight the high risk of advanced fibrosis/cirrhosis in T2DM patients aged >-50 years.
JOURNAL OF HEPATOLOGY
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Mark Barahman, Eduardo Grunvald, Pablo J. Prado, Alejandro Bussandri, Walter C. Henderson, Tanya Wolfson, Kathryn J. Fowler, Claude B. Sirlin
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sunyoung Lee, Yeun-Yoon Kim, Jaeseung Shin, Won Jeong Son, Yun Ho Roh, Jin-Young Choi, Claude B. Sirlin, Victoria Chernyak
Summary: The study aimed to estimate the percentages of hepatocellular carcinoma (HCC) and overall malignancy for each LI-RADS category using CT and MRI. The pooled percentages of HCC and overall malignancy did not differ between CT, MRI with extracellular contrast agents, and MRI with gadoxetate for any LI-RADS category.
Article
Oncology
Jessica P. Hwang, Kathryn B. Arnold, Joseph M. Unger, Rashmi Chugh, Monica A. Tincopa, Rohit Loomba, Dawn Hershman, Scott D. Ramsey
Summary: This study investigated the adherence to practice guidelines in patients with HBV, HCV, or HIV receiving anticancer treatment. It was found that many patients did not receive guideline-recommended antiviral treatment, indicating a need for further education to improve adherence to guidelines.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Computer Science, Interdisciplinary Applications
Jinyang Wang, Xiaoben Li, Mengyuan Ma, Changqing Wang, Claude B. Sirlin, Scott B. Reeder, Diego Hernando
Summary: This study aimed to model hepatic steatosis in adult humans with non-alcoholic fatty liver disease based on the stereology and spatial distribution of fat droplets. Histological analysis of liver biopsy specimens was performed, and the morphological features of fat droplets were characterized using the gamma distribution function in 2D and 3D spaces. Correlation analysis showed a strong relationship between the morphological features and fat fraction. Monte Carlo modeling was used to simulate the distribution of fat droplets in tissue. This study provides insights into the MRI signal behavior in the presence of liver steatosis.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Victoria Chernyak, Kathryn J. Fowler, Richard K. G. Do, Aya Kamaya, Yuko Kono, An Tang, Donald G. Mitchell, Jeffrey Weinreb, Cynthia S. Santillan, Claude B. Sirlin
Summary: Since its release in 2011, LI-RADS has evolved from a single algorithm for HCC diagnosis to a multialgorithm system covering all major liver imaging modalities. It has achieved global adoption in clinical care and research and unified HCC diagnostic systems in the US. However, there are still gaps in knowledge, such as challenges in surveillance, diagnostic population definition, and reporting. Future directions will focus on addressing these challenges and incorporating advanced technologies to create a probability-based system for liver cancer diagnosis and prognostication.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Roudenko, Zachary Berman, Joshua Cornman-Homonoff, Neil Halin, Mark Kleedehn, Kathryn J. Fowler, Mishal Mendiratta-Lalla, Victoria Chernyak, Claude B. Sirlin, Guilherme Moura Cunha
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Daniel Q. Q. Huang, Amit G. Singal, Fasiha Kanwal, Pietro Lampertico, Maria Buti, Claude B. Sirlin, Mindie H. Nguyen, Rohit Loomba
Summary: In this review, the authors discuss the current status of hepatocellular carcinoma (HCC) surveillance and the challenges that remain. They highlight the changing causes of liver disease and the need for strategies to improve the utilization and quality of surveillance. The underutilization of surveillance is attributed to limited disease awareness, knowledge gaps, and difficulty in identifying high-risk individuals. Non-alcoholic fatty liver disease and alcohol-associated liver disease are emerging as significant causes of HCC-related death, posing unique barriers to surveillance. The sensitivity of current surveillance approaches is limited, especially for patients with cirrhosis or obesity.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyang Liu, Stephanie B. M. Tan, Muhammad O. Awiwi, Hyun-Jung Jang, Victoria Chernyak, Kathryn J. Fowler, Akram M. Shaaban, Claude B. Sirlin, Alessandro Furlan, Robert M. Marks, Khaled M. Elsayes
Summary: Cirrhosis, the end stage of chronic liver disease, is a major risk factor for hepatocellular carcinoma (HCC). Benign and malignant lesions in cirrhosis can have both typical and atypical imaging features, which can be accurately diagnosed through various imaging modalities.