期刊
ACTA VETERINARIA BRNO
卷 78, 期 2, 页码 319-326出版社
VETERINARNI A FARMACEUTICKA UNIVERZITA BRNO
DOI: 10.2754/avb200978020319
关键词
Fish; parabens; preservatives; sex differentiation; vitellogenin; xeno-oestrogens
资金
- [MSM 6215712402]
The aim of the study was to evaluate the xeno-oestrogenic potential of propylparaben in vivo using zebrafish (Danio rerio). Experimental juvenile zebrafish (20 days post hatching) were fed a feed containing 500, 1000, or 2000 mg.kg(-1) of propylparaben, fish in a positive control group were given a feed treated with 20 mg.kg(-1) of 17 beta-oestradiol, and the control fish were given the feed free of either tested substance. The exposure of fish to propylparaben did not affect vitellogenesis after 20 days exposure but seemed to influence the sex differentiation processes, as evidenced by a sex ratio significantly skewed towards females in the group fed 500 mg.kg(-1) of propylparaben following 45 days of exposure. The potential of the fish to respond to oestrogenic stimulation was confirmed, since significantly higher vitellogenin concentrations were detected in the fish from the positive control group.
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